146,511 research outputs found
Emerald Case Study: Nike Davies-Okundaye: building a family social enterprise
No full textEmerging Markets Case Studies Collection.VOL. 2 NO. 8 2012, pp. 1-14, Emerald Group Publishing Limited, ISSN 2045-0621 EMERALD EMERGING MARKETS CASE STUDIESCase Stud
Week 96 efficacy and safety results of the phase 3, randomized EMERALD trial to evaluate switching from boosted-protease inhibitors plus emtricitabine/tenofovir disoproxil fumarate regimens to the once daily, single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) in treatment-experienced, virologically-suppressed adults living with HIV-1.
No full textDarunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg was investigated through 96 weeks in EMERALD (NCT02269917). Virologically-suppressed, HIV-1-positive treatment-experienced adults (previous non-darunavir virologic failure [VF] allowed) were randomized (2:1) to D/C/F/TAF or boosted protease inhibitor (PI) plus emtricitabine/tenofovir-disoproxil-fumarate (F/TDF) over 48 weeks. At week 52 participants in the boosted PI arm were offered switch to D/C/F/TAF (late-switch, 44 weeks D/C/F/TAF exposure). All participants were followed on D/C/F/TAF until week 96. Efficacy endpoints were percentage cumulative protocol-defined virologic rebound (PDVR; confirmed viral load [VL] ≥50 copies/mL) and VL < 50 copies/mL (virologic suppression) and ≥50 copies/mL (VF) (FDA-snapshot analysis). Of 1141 randomized patients, 1080 continued in the extension phase. Few patients had PDVR (D/C/F/TAF: 3.1%, 24/763 cumulative through week 96; late-switch: 2.3%, 8/352 week 52-96). Week 96 virologic suppression was 90.7% (692/763) (D/C/F/TAF) and 93.8% (330/352) (late-switch). VF was 1.2% and 1.7%, respectively. No darunavir, primary PI, tenofovir or emtricitabine resistance-associated mutations were observed post-baseline. No patients discontinued for efficacy-related reasons. Few discontinued due to adverse events (2% D/C/F/TAF arm). Improved renal and bone parameters were maintained in the D/C/F/TAF arm and observed in the late-switch arm, with small increases in total cholesterol/high-density-lipoprotein-cholesterol ratio. A study limitation was the lack of a control arm in the week 96 analysis. Through 96 weeks, D/C/F/TAF resulted in low PDVR rates, high virologic suppression rates, very few VFs, and no resistance development. Late-switch results were consistent with D/C/F/TAF week 48 results. EMERALD week 96 results confirm the efficacy, high genetic barrier to resistance and safety benefits of D/C/F/TAF
The invariance properties of the mutual information index group segregation
No full textThis article is © Emerald Group Publishing and permission has been granted for this version to appear here http://e-archivo.uc3m.es. Emerald does not grant permission for this article to be further copied/distributed or hosted elsewhere without the express permission from Emerald Group Publishing Limited
Reshaping Global Technology Development: Innovation and Entrepreneurship in China and India
No full textPurpose – This paper seeks to explore the processes by which the offshoring of technology development to India and China by Western and Japanese multinationals has evolved from the localization/simplification of technology for local markets to the development of advanced technology in India and China for global markets.
Design/methodology/approach – Case studies were developed based on 190 interviews conducted in China, India and several other countries. Respondents included multinational home country and offshore managers, as well as local entrepreneurs.
Findings – Rather than following carefully thought out corporate strategies, the offshoring of technology development by multinationals is more often incremental and driven by the ambitions and expectations of Chinese and Indian entrepreneurs and managers. Meanwhile ‘‘technology competition’’ policies proposed in the USA and elsewhere are not taking sufficient account of the processes by which technology development is being offshored.
Originality/value – Techno-nationalistic policies designed to allow one country to win a race with others in developing and monopolizing new technologies are increasingly dysfunctional. The identification of multinationals with ‘‘home countries’’ continues to weaken. At the same time, technologies and technology workers are more mobile than ever before. Better policies would allow nations to seek mutual benefit through today’s more globally dispersed technology development capabilities. Multinational managers in our study were not sufficiently accounting for the costs of offshoring and outsourcing technology, nor were they giving much thought to the longer term implications of their diminishing capabilities to develop or even control the development technology. More thought should be given to what aspects of technology constitute ‘‘core competencies’’ and which provide sustainable competitive advantage in the emerging global environment.This is the Version of Record, from the HTML version, provided by Emerald Group Publishing. This article is (c) Emerald Group Publishing and permission has been granted for this version to appear here (http://dx.doi.org/doi:10.7282/T31Z4693). Emerald does not grant permission for this article to be further copied/distributed or hosted elsewhere without the express permission from Emerald Group Publishing Limited.Peer reviewe
Ask Me Anything: What is Reddit?
No full textThis article provides a description of the crowdsourced website Reddit and how it may be useful to libraries and librarians.This article is (c) Emerald Group Publishing and permission has been granted for this version to appear here (http://dx.doi.org/doi:10.7282/T3D220BR). Emerald does not grant permission for this article to be further copied/distributed or hosted elsewhere without the express permission from Emerald Group Publishing Limited
Emerald Group Publishing: desafíos de las publicaciones tras la pandemia COVID–19
No full textSe nos referirá sobre la página "COVID-19: the latest research & publishing opportunities" que reúne las últimas investigaciones sobre el manejo de la epidemia y el impacto más amplio en la sociedad, junto con oportunidades de publicación de trabajos de investigación en Emerald Group Publishin
The Emerald Handbook of Authentic Leadership
No full textThe Emerald Handbook of Authentic Leadership is a quest for interdisciplinary insights arising out of theory and practice. It is intended for a wide readership interested in leadership and leadership authenticity in the contemporary world.</p
Parents’ views of supermarket fun foods and the question of responsible marketing
No full textThis article is (c) Emerald Group Publishing and permission has been granted for this version to appear here (please insert the web address here). Emerald does not grant permission for this article to be further copied/distributed or hosted elsewhere without the express permission from Emerald Group Publishing Limited." - See more at: http://www.emeraldgrouppublishing.com/authors/writing/author_rights.htm#sthash.K82YCAdJ.dpuf.YesPost print file deposited according to Emerald Group Publishing Author Rights policy http://www.emeraldgrouppublishing.com/authors/writing/author_rights.htm, August, 20, 2014.CIH
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