856 research outputs found

    Open access self-archiving: An author study

    No full text
    This, our second author international, cross-disciplinary study on open access had 1296 respondents. Its focus was on self-archiving. Almost half (49%) of the respondent population have self-archived at least one article during the last three years. Use of institutional repositories for this purpose has doubled and usage has increased by almost 60% for subject-based repositories. Self-archiving activity is greatest amongst those who publish the largest number of papers. There is still a substantial proportion of authors unaware of the possibility of providing open access to their work by self-archiving. Of the authors who have not yet self-archived any articles, 71% remain unaware of the option. With 49% of the author population having self-archived in some way, this means that 36% of the total author population (71% of the remaining 51%), has not yet been appraised of this way of providing open access. Authors have frequently expressed reluctance to self-archive because of the perceived time required and possible technical difficulties in carrying out this activity, yet findings here show that only 20% of authors found some degree of difficulty with the first act of depositing an article in a repository, and that this dropped to 9% for subsequent deposits. Another author worry is about infringing agreed copyright agreements with publishers, yet only 10% of authors currently know of the SHERPA/RoMEO list of publisher permissions policies with respect to self-archiving, where clear guidance as to what a publisher permits is provided. Where it is not known if permission is required, however, authors are not seeking it and are self-archiving without it. Communicating their results to peers remains the primary reason for scholars publishing their work; in other words, researchers publish to have an impact on their field. The vast majority of authors (81%) would willingly comply with a mandate from their employer or research funder to deposit copies of their articles in an institutional or subject-based repository. A further 13% would comply reluctantly; 5% would not comply with such a mandate

    On exclusive h→Vl+l− decays

    No full text
    We study a set of exclusive decay modes of the Standard Model Higgs boson into a vector meson and a dilepton pair: h→Vl+l−, with V=Υ,J/ψ,φ, and l=μ,τ, determining the decay rates, the dilepton mass spectra and the V longitudinal helicity fraction distributions. In the same framework, we analyze the exclusive modes into neutrino pairs View the MathML source. We also discuss the implications of the recent CMS and ATLAS results for the lepton flavor-changing process h→τ+μ− on the h→Vτ+μ− decay mode

    Tolerable degree of muscle sacrifice when harvesting a vastus lateralis or myocutaneous anterolateral thigh flap

    No full text
    The myocutaneous anterolateral thigh (ALT) and vastus lateralis (VL) flaps include a large muscle mass and a sufficient vascular pedicle, and they have been used for decades to reconstruct traumatic and acquired defects of the head and neck and extremities. In spite of these benefits, musculoskeletal dysfunction was reported in nearly 1 out of 20 patients at follow-up. It is unclear whether the recently proposed muscle-sparing flap-raising approach could preserve VL muscle function and whether patients at increased risk could benefit from such an approach. Therefore, we performed a predictive dynamic gait simulation based on a biological motion model with gradual weakening of the VL during a self-selected and fast walking speed to determine the compensable degree of VL muscle reduction. Muscle force, joint angle, and joint moment were measured. Our study showed that VL muscle reduction could be compensated up to a certain degree, which could explain the observed incidence of musculoskeletal dysfunction. In elderly or fragile patients, the VL muscle should not be reduced by 50% or more, which could be achieved by muscle-sparing flap-raising of the superficial partition only. In young or athletic patients, a VL muscle reduction of 10%, which corresponds to a muscle cuff, has no relevant effect. Yet, a reduction of more than 30% leads to relevant weakening of the quadriceps. Therefore, in this patient population with the need for a large portion of muscle, alternative flaps should be considered. This study can serve as the first basis for further investigations of human locomotion after flap-raising.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Biomechatronics & Human-Machine Contro

    Anisotropy Indicators of High-Strength Steel 42H2GSNMA (VKS-1) and 30H2GSNVM (Vl-1d)

    No full text
    Поставлены опыты по растяжению образцов из сталей 42Х2ГСНМА (ВКС-1) и 30Х2ГСНВМ (ВЛ-1 Д) с изменением ориентации образцов относительно оси прокатки. Выполнены расчеты и получены показатели анизотропии высокопрочных сталей 42Х2ГСНМА (ВКС-1) и 30Х2ГСНВМ (ВЛ-1 Д) в отожженном состоянии.Experiments on stretching samples of steels 42H2GSNMA (VKS-1) and 30H2GSNVM (VL-1D) with a change in the orientation of the samples relative to the rolling axis were carried out. Calculations have been carried out and anisotropy indices have been obtained for high-strength 42H2GSNMA (VKS-1) and 30H2GSNVM (VL-1D) steels in the annealed state.Автор выражает благодарность научному руководителю — доктору технических наук, профессору Ю.Н. Логинову.The author expresses gratitude to the scientific advisor — doctor of technical sciences, professor Yu.N. Login

    A VL single-domain antibody library shows a high-propensity to yield non-aggregating binders

    No full text
    A synthetic human VL phage display library, created by the randomization of all complementarity-determining regions (CDRs) in a V L scaffold, was panned against three test antigens to determine the propensity of the library to yield non-aggregating binders. A total of 22 binders were isolated against the test antigens and the majority (20) were monomeric. Thus, human VL repertoires provide an efficient source of non-aggregating binders and represent an attractive alternative to human V H repertoires, which are notorious for containing high proportions of aggregating species. Moreover, the solubility of VLs, in contrast to VHs, appears much less CDR dependent. \ua9 The Author 2012. Published by Oxford University Press.Peer reviewed: YesNRC publication: Ye
    corecore