2,068 research outputs found
Disputatio Medica De Generatione Hominis In Ovo / Quam, ... Sub Praesidio ... Dn. Johannis Jacobi Waldschmied/ Medicinae Doctoris ... exhibet Author Dominicus Beddevole, Genevensis, In Auditorio Medico d. 3. Septemb. ...
No full textDISPUTATIO MEDICA DE GENERATIONE HOMINIS IN OVO / QUAM, ... SUB PRAESIDIO ... DN. JOHANNIS JACOBI WALDSCHMIED/ MEDICINAE DOCTORIS ... EXHIBET AUTHOR DOMINICUS BEDDEVOLE, GENEVENSIS, IN AUDITORIO MEDICO D. 3. SEPTEMB. ...
Disputatio Medica De Generatione Hominis In Ovo / Quam, ... Sub Praesidio ... Dn. Johannis Jacobi Waldschmied/ Medicinae Doctoris ... exhibet Author Dominicus Beddevole, Genevensis, In Auditorio Medico d. 3. Septemb. ... (1)
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Consensu Et Author. Magnifici Ictorum Ordinis In Illustri Ad Salam Academia, Sub Praesidio ... Dn. Joh. Volk. Bechmanns ... Dissertationem Iuridicam De Iure Braxandi in Ictorum Auditorio ad diem Octobr. h.c. Publicae Eruditorum Censurae Subiiciet Paul. Christianus Arnoldus, Olsnen. Siles. Author & Respondens
No full textCONSENSU ET AUTHOR. MAGNIFICI ICTORUM ORDINIS IN ILLUSTRI AD SALAM ACADEMIA, SUB PRAESIDIO ... DN. JOH. VOLK. BECHMANNS ... DISSERTATIONEM IURIDICAM DE IURE BRAXANDI IN ICTORUM AUDITORIO AD DIEM OCTOBR. H.C. PUBLICAE ERUDITORUM CENSURAE SUBIICIET PAUL. CHRISTIANUS ARNOLDUS, OLSNEN. SILES. AUTHOR & RESPONDENS
Consensu Et Author. Magnifici Ictorum Ordinis In Illustri Ad Salam Academia, Sub Praesidio ... Dn. Joh. Volk. Bechmanns ... Dissertationem Iuridicam De Iure Braxandi in Ictorum Auditorio ad diem Octobr. h.c. Publicae Eruditorum Censurae Subiiciet Paul. Christianus Arnoldus, Olsnen. Siles. Author & Respondens ([1])
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De. Condictione L. Si quis Conductionis. 25. C. de locato conducto. Sub Praesidio Dn. Andreae Mylii ... Publice disputabit. Author. Johann Gottfried Schönfeld/ Zitt. Lus. die 11. Iunii. M.DC.XCVI.
No full textDE. CONDICTIONE L. SI QUIS CONDUCTIONIS. 25. C. DE LOCATO CONDUCTO. SUB PRAESIDIO DN. ANDREAE MYLII ... PUBLICE DISPUTABIT. AUTHOR. JOHANN GOTTFRIED SCHÖNFELD/ ZITT. LUS. DIE 11. IUNII. M.DC.XCVI.
De. Condictione L. Si quis Conductionis. 25. C. de locato conducto. Sub Praesidio Dn. Andreae Mylii ... Publice disputabit. Author. Johann Gottfried Schönfeld/ Zitt. Lus. die 11. Iunii. M.DC.XCVI. (1)
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Dissertatio De Censu Augusti / Quam Sub Praesidio ... Dn. Ulrici Obrechti, In Alma Argentinensium Universitate Professoris Histor. ... Ad Examen Solenne Proponit Michael Förtsch/ Wertheimio-Francus Author. A. D. [...] Maii MDCLXXV.
No full textDISSERTATIO DE CENSU AUGUSTI / QUAM SUB PRAESIDIO ... DN. ULRICI OBRECHTI, IN ALMA ARGENTINENSIUM UNIVERSITATE PROFESSORIS HISTOR. ... AD EXAMEN SOLENNE PROPONIT MICHAEL FÖRTSCH/ WERTHEIMIO-FRANCUS AUTHOR. A. D. [...] MAII MDCLXXV.
Dissertatio De Censu Augusti / Quam Sub Praesidio ... Dn. Ulrici Obrechti, In Alma Argentinensium Universitate Professoris Histor. ... Ad Examen Solenne Proponit Michael Förtsch/ Wertheimio-Francus Author. A. D. [...] Maii MDCLXXV. (1)
Titelblatt (1)
Dissertatio De Censu Augusti (3
Lifelong Learning: a Posthuman Condition?
No full textFirst paragraph: This chapter is a thing, a gathering around a matter of concern. There is a gathering in the writing of the text, its editing and publication and its reading. It is therefore a gathering across space and time, a thing which changes, translates and betrays (Latour 1996 ) in the process of its gathering, of thinging . A strange beginning for a chapter on lifelong learning perhaps... One that may not encourage gathering - you may skip to the next chapter. However, I hope by the end of this experiment that the concerning matter has become a gathering, a thing to be referenced perhaps
Tractatio Iuris Publici De Serenissimis Potentissimisque Ducibus Brunsvicensibus Et Luneburgensibus / D.O.M.A. Praeside ... Dn. Joh. Ulrico Pregizero ... In Illustri Collegio Ad Diem 10. Decembr. Placido Eruditorum Examini sistit Author Christian Ulrich Blum
No full textTRACTATIO IURIS PUBLICI DE SERENISSIMIS POTENTISSIMISQUE DUCIBUS BRUNSVICENSIBUS ET LUNEBURGENSIBUS / D.O.M.A. PRAESIDE ... DN. JOH. ULRICO PREGIZERO ... IN ILLUSTRI COLLEGIO AD DIEM 10. DECEMBR. PLACIDO ERUDITORUM EXAMINI SISTIT AUTHOR CHRISTIAN ULRICH BLUM
Tractatio Iuris Publici De Serenissimis Potentissimisque Ducibus Brunsvicensibus Et Luneburgensibus / D.O.M.A. Praeside ... Dn. Joh. Ulrico Pregizero ... In Illustri Collegio Ad Diem 10. Decembr. Placido Eruditorum Examini sistit Author Christian Ulrich Blum (1)
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Do urine vesicles offer a fingerprint of chronic kidney disease progression?
No full textDiabetic nephropathy (DN) is the most prevalent form of chronic kidney disease (CKD), with symptoms typically appearing in the later stages. As a result, it frequently progresses to renal fibrosis and kidney failure. Despite an increasing number of studies is focusing on biomarkers for DN and other types of CKD, there is still a pressing need to discover non-invasive markers for monitoring the progression of DN. Urinary extracellular vesicles (uEVs) are a promising source of kidney disease biomarkers since they are secreted from kidney cells, play a role in inter-cellular communication, and carry molecular cargo that reflects pathophysiological conditions. The primary aim of this study was to use a multi omics approach to identify a multi-marker panel of DN progression employing uEVs as a source of biomarkers (proteins, miRNAs) and chemical-physical features such as surface charge. Exploring the interaction between uEVs miRNA and protein markers of DN was a further key objective expected to uncover new regulatory mechanisms involved in DN.
Cell-free urine samples of DN (n=53), diabetes with no CKD (n=20), and healthy (n=20) cohorts were sourced from Sheffield Kidney Institute (UK) and Patras University Hospital (Greece) with uniform standardised criteria and informed consent. DN cohorts were stratified in stable and progressive disease based on rate of eGFR loss, respectively 5 ml/min/year (n=25). uEVs were isolated and characterised with adherence to MISEV. Protein uEVs markers were identified through quantitative proteomics of uEVs lysates for each subject and a selection validated using single EV analysis directly in biofluids (pooled samples). miRNA markers were detected via miRNA sequencing on individual samples and by NanoString digital profiling (in pool) and validated by TaqMan Advanced qPCR. uEVs surface charge was measured in individual subjects uEVs preparations.
Quantitative proteomics revealed 72 proteins with differential expression in progressive versus stable DN when normalised to equal uEVs protein (46 proteins when normalised to equal volume of starting urine). The differential expression of five proteins was confirmed in progressive DN (Vasorin, Podocalyxin, Mucin 1, Ganglioside GM2 activator, 5 and Argininosuccinate synthase). Transcriptomic analyses identified four miRNAs with differential expression in progressive versus stable DN of which three (miR-99a-5p, miR 223-3p, miR-3613-5p) exhibited the same expression trend when validated. Moreover, a panel of proteins and miRNAs (L-lactate dehydrogenase C chain, Muscleblind-like protein-1, miR-891a-5p, miR-432-5p, miR-890, miR-892a) was found significantly altered in DN compared to diabetes. As miR-99a-5p and miR-223-3p were predicted to directly target and regulate the expression of Muscleblind-like protein 1, their direct interaction was confirmed by 3’UTR luciferase reporter system in transfected HK2 cells. Quantification of uEVs surface charge revealed a significantly less negative charge in diabetes without CKD than in DN uEVs (p<0.05), suggestive of glycomics changes.
In conclusion, this study has identified and validated a novel panel of uEV markers for DN progression, which could assist in stratifying DN, particularly patients who are at risk of progressing to the advanced progressive stage. The crosstalk between uEV miRNAs and proteins dysregulated in DN raises new research questions that could help uncover mechanisms of DN pathogenesis and increased severity
Rational conjugacy classes of maximal tori in groups of Dn
No full textAuthor original manuscript (preprint)We give a concrete characterization of the rational conjugacy classes of maximal tori in groups of type Dn, with specific emphasis on the case of number fields and p-adic fields. This includes the forms associated to quadratic spaces, all of their inner and outer forms as well as the Spin groups, their simply connected covers. In particular, in this work, we handle all (simply connected) outer forms of D4.N
Dn. Iohannes Kellerus
No full textHalbfigur nach rechts, die rechte Hand in die Taille gestützt; links und rechts vom Ovalrahmen sind ein Rüstungshelm und das Wappen der Familie Keller zu sehenJoh. Meyer fecit Ao. 1703Vgl. die Zeichnung von Conrad Meyer, Signatur: Pp A4, sowie die Druckgraphik, Signatur: Keller, Johannes a) I, 2Porträt des Zürcher Bürgermeisters Johannes Keller (erstmals erwähnt 1417-1460/61)Inschrift unter dem Bild: "Dn: Iohannes Kellerus, / Reipubl: Tigur: Consul. / Ao. D. 1445"; weitere Inschrift: "Dives opum, et pacis Cellarius optimus Author / Composuit longâ bella patrata morà. / Quin etiam patriis Kyburgum finibus arcem. / Adjecit totâ cum ditione suâ."Signiert rechts unten: "Joh. Meyer fecit. Ao. 1703"Nummeriert unten in der Mitte unterhalb des Ovalrahmens: "18." Am Blattrand oben handschriftlich in brauner Tinte biografische Angaben zu Joahnnes Keller in VersformIn Peter Mortzfeld: Katalog der graphischen Porträts in der Herzog-August-Bibliothek Wolfenbüttel nicht verzeichne
Dn. Iohannes Kellerus
No full textHalbfigur nach rechts, die rechte Hand in die Taille gestützt; links und rechts vom Ovalrahmen sind ein Rüstungshelm und das Wappen der Familie Keller zu sehenJoh. Meyer fecit Ao. 1703Vgl. die Zeichnung, Signatur: Keller, Joh. a) I, 4 Pp A4, sowie die Druckgraphik, Signatur: Keller, Johannes a) I, 3Porträt des Zürcher Bürgermeisters Johannes Keller (erstmals erwähnt 1417-1460/61)Inschrift unter dem Bild: "Dn: Iohannes Kellerus, / Reipubl: Tigur: Consul. / Ao. D. 1445" Weitere Inschrift: "Dives opum, et pacis Cellarius optimus Author / Composuit longâ bella patrata morà. / Quin etiam patriis Kyburgum finibus arcem. / Adjecit totâ cum ditione suâ."Signiert rechts unten: "Joh. Meyer fecit. Ao. 1703"Nummeriert unten in der Mitte unterhalb des Ovalrahmens: "18."In Mortzfeld nicht verzeichne
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