1,721,444 research outputs found
Guideline on the design and conduct of cystic fibrosis clinical trials: the European Cystic Fibrosis Society-Clinical Trials Network (ECFS-CTN).
No full textWe describe the rationale for disease specific research networks in general as well as the aims and function of the European Cystic Fibrosis Society-Clinical Trials Network (ECFS-CTN) specifically. The ECFS-CTN was founded in 2009 with the aim of improving the quality and quantity of clinical research in the area of cystic fibrosis (CF) in Europe. A network of 18 clinical trial sites in 8 European countries was established according to uniform state-of-the-art quality criteria. To support the ECFS-CTN in the acquisition, planning and conduct of clinical trials, the network is equipped with a coordinating centre, steering and executive committees, and committees for protocol review, standardization, training and networking as well as a data safety monitoring board. A strong partnership with European CF patient parent organizations aims to increase awareness of the need for efficient clinical research and the participation of patients in clinical trials
Impact of the A (H1N1) pandemic influenza (season 2009-2010) on patients with cystic fibrosis.
No full textBACKGROUND:
Influenza, like other respiratory viral infections, can cause acute deterioration of lung function in patients with cystic fibrosis (CF). Previous studies on a small number of patients reported that most people with CF infected with A (H1N1) influenza experienced a mild course of disease.
AIM:
To characterise the impact of A (H1N1) infection on CF in a large number of patients from different centres and countries.
METHODS:
CF centres accessing the web-site of the European Cystic Fibrosis Society (ECFS) were asked to report clinical data on patients with an ascertained diagnosis of influenza caused by the A (H1N1) virus. The study was web-based and data were collected through an electronic data sheet on the ECFS website.
RESULTS:
Twenty-five centres from 10 countries caring for 4698 patients with CF reported data on 110 patients (2.3%), median age 13 years (range 1-39 years). The prevalence of infection in each centre ranged from 0% to 9.4%. Only 8.8% of the patients had been vaccinated. The main symptoms were fever and respiratory exacerbation requiring IV antibiotics in 53% of the patients; 48% of the patients were hospitalised for an average of 12.9 days (range 2-56) and 31% required oxygen treatment during the time of the infection. Most of the patients recovered and FEV(1) 1 month after the infection was similar to that before the infection. However, 6 patients were admitted to ICU, 5 with mechanical ventilation. Three patients with severe respiratory disease died.
CONCLUSIONS:
A (H1N1) influenza infection caused transient but significant morbidity in most of the patients with CF. However, in a small number of patients with severe lung disease, A (H1N1) influenza was associated with respiratory deterioration, mechanical ventilation and even death
Impact of the A (H1N1) pandemic influenza (season 2009-2010) on patients with cystic fibrosis.
No full textAssael BM, Barreto C, Bentur L, Bhatt JM, Repetto T, Chipps B, Colombo C, De Boeck K, Derelle J, Desager KN, Salvatore D, Escribano A, Kerem E, Lebecque P, Lischka A, Lucidi V, Malfroot A, Minicucci L, Munck A, Padoan R, Pardo F, Collura M, Raia V, Lutz N, Van Daele S, Vazquez C.
Source
Dipartimento di Medicina del Lavoro Clinica del Lavoro L. Devoto, Sezione di Statistica Medica e Biometria G.A.Maccacaro, Università degli Studi di Milano, Italy.
Abstract
BACKGROUND:
Influenza, like other respiratory viral infections, can cause acute deterioration of lung function in patients with cystic fibrosis (CF). Previous studies on a small number of patients reported that most people with CF infected with A (H1N1) influenza experienced a mild course of disease.
AIM:
To characterise the impact of A (H1N1) infection on CF in a large number of patients from different centres and countries.
METHODS:
CF centres accessing the web-site of the European Cystic Fibrosis Society (ECFS) were asked to report clinical data on patients with an ascertained diagnosis of influenza caused by the A (H1N1) virus. The study was web-based and data were collected through an electronic data sheet on the ECFS website.
RESULTS:
Twenty-five centres from 10 countries caring for 4698 patients with CF reported data on 110 patients (2.3%), median age 13 years (range 1-39 years). The prevalence of infection in each centre ranged from 0% to 9.4%. Only 8.8% of the patients had been vaccinated. The main symptoms were fever and respiratory exacerbation requiring IV antibiotics in 53% of the patients; 48% of the patients were hospitalised for an average of 12.9 days (range 2-56) and 31% required oxygen treatment during the time of the infection. Most of the patients recovered and FEV(1) 1 month after the infection was similar to that before the infection. However, 6 patients were admitted to ICU, 5 with mechanical ventilation. Three patients with severe respiratory disease died.
CONCLUSIONS:
A (H1N1) influenza infection caused transient but significant morbidity in most of the patients with CF. However, in a small number of patients with severe lung disease, A (H1N1) influenza was associated with respiratory deterioration, mechanical ventilation and even death
ECFS CTN measurement of body mass index
No full textThis SOP has been developed to standardise body mass index (BMI) assessment for use in clinical trials.It represents guidance based upon current best practice.Local practices for BMI assessment outside of ECFS-CTN activities do not need to be changed in line with this SOP.PURPOSEThe purpose of this procedure is to develop a standardised, accurate and reproducible method of obtaining BMI measurements from children and adults enrolled in clinical trials within the European Cystic Fibrosis Society Clinical Trial Network (ECFS CTN).SCOPETo ensure that ECFS CTN study sites perform BMI measurement in a reproducible and standardised manner. To ensure quality and reliability of the data collected and analysed, each individual site should follow the guidelines described below
ECFS CTN measurement of weight standard operating procedure
No full textSCOPE To ensure that ECFS CTN study sites perform weight measurement in a reproducible and standardised manner. To ensure quality and reliability of the data collected and analysed, each individual site should follow the guidelines described below and have received training in the use of growth charts.Access to this document is allowed by the publisher “on request” only to the author Kate Hill to email [email protected]<br/
TWO DECADES OF RESEARCH ON EARLY CAREER FACULTIES (ECFs): A BIBLIOMETRIC ANALYSIS OF TRENDS ACROSS REGIONS
No full textEarly Career Faculties (ECFs) are an important demographic of university faculty population shaping the future of the institution and higher education, despite the challenges they face as new academics. Analysis of scholarly output on ECFs offers useful data to inform and aid both national policy formulations and institutional planning decisions especially in ECFs’ support and development. Peer-reviewed high impact journals and academic databases provide highly valid and reliable sources of data and information on ECFs. This study examines the trend of ECFs research over two decades comparing scholarly output and research impact across global regions, in Web of Science and Scopus Elsevier. The bibliometric analysis highlights key topics of research and publications related to ECFs and identify the regions and countries most actively research on the topic. The trend of research on ECFs has been found to increase exponentially beginning the 1990s worldwide, mostly from western institutions (76%). Publications after the year 2012 focused more on issues related to ECFs’ preparation towards life in academia, their motivation, and challenges, the support structure for ECFs and strategies to adapt to life as faculty members. Such bibliometric analysis findings can be a useful reference for policy formulation within national or regional systems of higher education, and institutional strategic planning.<br
Sweat Induction and Collection Macroduct Advanced SOP
No full textThis procedure provides instruction for sweat induction and collection using the ELITech Macroduct® Advanced Sweat Collection System. The method was developed as a collaboration of the European Cystic Fibrosis Society Clinical Trial Network (ECFS-CTN) and the Cystic Fibrosis Foundation Therapeutics Development Network(CFF-TDN)
Two decades of research on early career faculties (ECFs): A bibliometric analysis of trends across regions
No full textEarly Career Faculties (ECFs) are an important demographic of university faculty population shaping the future of the institution and higher education, despite the challenges they face as new academics. Analysis of scholarly output on ECFs offers useful data to inform and aid both national policy formulations and institutional planning decisions especially in ECFs' support and development. Peer-reviewed high impact journals and academic databases provide highly valid and reliable sources of data and information on ECFs. This study examines the trend of ECFs research over two decades comparing scholarly output and research impact across global regions, in Web of Science and Scopus Elsevier. The bibliometric analysis highlights key topics of research and publications related to ECFs and identify the regions and countries most actively research on the topic. The trend of research on ECFs has been found to increase exponentially beginning the 1990s worldwide, mostly from western institutions (76%). Publications after the year 2012 focused more on issues related to ECFs' preparation towards life in academia, their motivation, and challenges, the support structure for ECFs and strategies to adapt to life as faculty members. Such bibliometric analysis findings can be a useful reference for policy formulation within national or regional systems of higher education, and institutional strategic planning. © 2020 Universiti Putra Malaysia Press
ECFS CTN measurement of height standard operating procedure
No full textPURPOSE The purpose of this procedure is to develop a standardised, accurate and reproducible method of obtaining height measurements from children and adults enrolled in clinical trials within the European Cystic Fibrosis Society Clinical Trial Network (ECFS CTN). SCOPE To ensure that ECFS CTN study sites perform height measurement in a reproducible and standardised manner. To ensure quality and reliability of the data collected and analysed.<br/
A study on dielectric constants of epoxy/SrTiO3 composite for embedded capacitor films (ECFs)
No full textEpoxy/BaTiO3 composites have been of great interest as embedded capacitor materials, mainly due to high dielectric constant of ceramic powders, and good process compatibility of epoxy with printed circuit boards (PCBs). However, one of the potential problems of epoxy/BaTiO3 composite is the dielectric relaxation at gigahertz range. In this paper, epoxy/SrT'O-3 composite embedded capacitor films (ECFs) were fabricated for high-frequency applications. Dielectric constants of epoxy/SrTiO3 composite embedded capacitor films with various SrTiO3 particles loading for three different commercial SrTiO3 powders were measured, and experimental data were fitted to the Lichtenecker equation for the prediction of the effective dielectric constant of SrTiO3 powders in epoxy/SrTiO3 composite ECFs. Using a rectangular cavity resonator method, dielectric constants of epoxy/SrTiO3 composite ECFs were measured at gigahertz range (1-10 GHz). At gigahertz frequencies, dielectric constants of epoxy/SrTiO3 composite ECFs were nearly constant. In contrast, epoxy/BaTiO3 composite ECFs showed decrease of dielectric constants above 5 GHz. Therefore, it is concluded that epoxy/SrTiO3 composite ECFs can be more effectively to be applied for high-frequency applications
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