65 research outputs found
Synthesis of 4-allyl-4-arylaminopiperidines and their transformations to spiro[tetrahydroquinoline-2,4′-piperidines]
No full textIt was established that the yields of a 4-allyl-4-aryl-aminopiperidines in the reaction of 4-aryliminopiperidines with allylmagnesium bromide increase significantly if the reaction is carried out in the presence of a crown ether. A number of previously unknown spiro[tetrahydroquinoline-2,4′-piperidines] were obtained in the cyclization of 4-allyl-4-arylaminopiperidines in the presence of sulfuric acid. © 1990 Plenum Publishing Corporation
SYNTHESIS OF 4-ALLYL-4-ARYLAMINOPIPERIDINES AND THEIR TRANSFORMATIONS INTO SPYRO[TETRAHYDROQUINOLINE-2,4'-PIPERIDINES]
No full textSynthesis of 4-allyl-4-arylaminopiperidines and their transformations to spiro[tetrahydroquinoline-2,4′-piperidines]
No full textIt was established that the yields of a 4-allyl-4-aryl-aminopiperidines in the reaction of 4-aryliminopiperidines with allylmagnesium bromide increase significantly if the reaction is carried out in the presence of a crown ether. A number of previously unknown spiro[tetrahydroquinoline-2,4′-piperidines] were obtained in the cyclization of 4-allyl-4-arylaminopiperidines in the presence of sulfuric acid. © 1990 Plenum Publishing Corporation
An efficient synthesis of hexahydro oxaisoindolo[2,1-a]quinoline derivatives via the Diels-Alder reactions
No full textKouznetsov, V.V. (reprint author), Univ Talca, Inst Quim Recursos Nat, Lab Sintesis Organ, Casilla 747, Talca, Chile.he straight forward synthesis of new carboxylic acids with hexahydro-oxaisoindolo[2.1-a]quinoline core from the 2,4-disustituted 1,2,3,4-tetrallydroquinolines bearing a furan fragment via the intramolecular Diels-Alder reaction has been proposed. It was demonstrated that synthesis of key precursors can be realized with excellent level of diastereoselectivity either by imino-Diels-Alder reaction or multi-component condensation approach
Mass spectrometric study of 2-keto(thio)tetrahydropyrimidine derivatives
No full textThe fragmentation pathways of 2-keto(thio)-6-methyl-5-carbethoxy(acetyl)-4-aryl-1,2,3,4-tetrahydropyrimidines were established using high resolution mass spectra and DADI spectra. An unusual rearrangement was observed, which involves cyclization of the aryl substituent in the 4 position with the oxygen of an ester group and elimination of a C2H5 radical. © 1989 Plenum Publishing Corporation
Mass spectrometric study of 2-keto(thio)tetrahydropyrimidine derivatives
No full textThe fragmentation pathways of 2-keto(thio)-6-methyl-5-carbethoxy(acetyl)-4-aryl-1,2,3,4-tetrahydropyrimidines were established using high resolution mass spectra and DADI spectra. An unusual rearrangement was observed, which involves cyclization of the aryl substituent in the 4 position with the oxygen of an ester group and elimination of a C2H5 radical. © 1989 Plenum Publishing Corporation
Diagnostics and self-diagnostics as resources of implementation of the competent approach to professional education
No full textThe author of the article discusses the problems of implementing a competence approach to vocational education from the standpoint of the value-goal priorities of advanced education. The main attention is drawn to the ways of diagnosing the results of professional and personal development of students and the importance of self-diagnosisОбсуждаются проблемы реализации компетентностного подхода к профессиональному образованию с позиций ценностно-целевых приоритетов опережающего образования. Основное внимание обращается на способы диагностики результатов профессионально-личностного развития студентов и значение самодиагностик
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