73 research outputs found
Linear white lesion in the oral mucosa
No full textTwo unrelated patients aged 60 and 61 presented with an asymptomatic, white, slightly raised line on the buccal mucosa extending bilaterally from the commissure to the last molar teeth along their occlusal line, involving also the inner lower lip mucosa (Fig 1, A and B). The lesions could not wipe off on scratching. Medical history was unremarkable. Histopathology showed hyperparakeratosis without granular layers and regular acanthosis vacuolated cells in the upper spinous cell layer with some dyskeratotic cells in the absence of dysplasia (Fig 2). Neither inflammatory infiltrate nor bacterial colonies attached to the surface or fungal elements were seen (Fig 3)
Efficacy of Imiquimod 3.75% for the treatment of extensive Bowen's disease of the face in an elderly patient
No full textBowen's disease is a cutaneous squamous cell carcinoma (SCC) in situ with a potential risk of progression to invasive SCC. Despite the high number of approved treatments, elderly patients with extensive lesions of critical sites may represent a therapeutical challenge, especially in cases of treatment failure or recalcitrant disease. Here, we report the successfully use of topical Imiquimod 3.75% to treat an extensive Bowen's disease of the cheek in an elderly
Molecular Basis of the ABA Dependent Modulation of CONSTANS Activity in Drought Escape Response
No full textPlants ability to adapt their development in response to environmental changes is one key factor underlying their evolutionary success. Phytohormones modulate different plant–environment interactions, namely the regulation of flowering time that is crucial to synchronize the onset of the reproductive phase with the most favorable conditions. In Arabidopsis thaliana the plant hormone abscisic acid (ABA), known to regulate various drought stress responses, promotes flowering under long day but not short day conditions. Genetic analyses support a model where ABA signals interact with the photoperiodic pathway, upstream of the flowering gene FLOWERING LOCUS T. Aims of my project are to define how ABA and photoperiod signaling interact. My genetic data indicates that ABA promotes flowering by modulating the activity of the FT activator CONSTANS (CO) rather than its transcriptional regulation. Initial data about the molecular basis of this ABA–CO interaction will be presented. Our study point to CO as the key integrator between ABA signals and the photoperiodic pathway, allowing plants to coordinate flowering time according to the prevailing watering conditions
Histologic features of long‐lasting chilblain‐like lesions in a paediatric COVID‐19 patient
No full textAcute generalized exanthematous pustulosis with erythema multiforme‐like lesions induced by Hydroxychloroquine in a woman with coronavirus disease 2019 (COVID‐19)
No full textCoronavirus disease 2019 (COVID-19) rash in a psoriatic patient treated with Secukinumab: Is there a role for Interleukin 17?
No full textBird strike tests : update of the impact testing facility and numerical investigation on bird, sabot and stopper FE models
No full textLAUREA MAGISTRALELe prove di impatto volatile sono fondamentali per lo sviluppo e la certificazione
di velivoli contro tale collisione. Gli aeromobili devono resistere a diverse
tipologie di impatto, garantendo l’operatività degli stessi e la sicurezza degli
occupanti.
I cannoni ad aria sono utilizzati per accelerare proiettili, sia volatili reali per prove
omologative che surrogati di volatile per prove di sviluppo, contro l’oggetto
della prova.
Le normative impongono massa, dimensioni e velocità del proiettile, ma viene
lasciata piena libertà nella scelta del metodo con cui effettuare la prova. Questo
ha dato spazio allo sviluppo di tipologie differenti di lanciatori, ognuna avente
pregi e difetti.
In questa tesi è descritta l’analisi e lo sviluppo di un cannone ad aria con innesco
a lamina, presente originariamente in laboratorio. Sono analizzate le principali
criticità di questa tipologia di sistema, che hanno portato alla sostituzione dell’innesco
a lamina con una valvola rapida utilizzata normalmente per rimuovere
occlusioni e intasamenti in silos contenenti materiale sfuso.
Questo lanciatore ad aria è stato utilizzato per svolgere prove di impatto volatile
contro un bersaglio rigido. I dati ottenuti sono stati utilizzati per la validazione
di un modello numerico, nel quale il volatile è costituito da elementi di tipo
SPH.
Sono inoltre mostrate simulazioni numeriche per lo sviluppo di un nuovo sistema
di stopper e di sabot.Bird impact tests are of paramount importance for development and certification
of aircrafts, which must withstand different types of impact, guaranteeing
the safety of the occupants and their operation.
The air cannons are used to accelerate projectiles, real birds for homologation
tests and volatile surrogates for development tests, against the component being
tested.
The regulations impose mass, dimensions and speed of the projectile but no
constraints on the method to carry out the test. This led to the development
of different types of air cannons, each having strengths and weaknesses.
This thesis describes the analysis and improvement of an air cannon with single
diaphragm system, available in the laboratory. The main critical points of
this type of system are analyzed, leading to the replacement of the diaphragm
system with a rapid valve, normally used to remove blockages and clogging in
silos containing loose material.
This air cannon has been used to carry out volatile impact tests against a rigid
target. The data obtained were used for the validation of a numerical model,
in which the volatile is represented with SPH elements.
Numerical simulations are also shown for the development of a new stopper and
sabot system
No evidence of increased risk for Coronavirus Disease 2019 (COVID‐19) in patients treated with Dupilumab for atopic dermatitis in a high‐epidemic area – Bergamo, Lombardy, Italy
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