1,720,983 research outputs found
Drug monitoring in the therapeutic environment
No full textA review, with 13 refs., considering 2 related topics: pharmacokinetic concepts for predicting blood levels of a drug following a given dose, and anal. methods for the detn. and monitoring of the concns. actually attained
Il mercato della droga a Piacenza negli anni 1987-2000. Nota 2: i soggetti coinvolti
No full textNel presente lavoro è stata effettuata una verifica dell’andamento del mercato clandestino della droga nella città di Piacenza nel corso degli anni 1987-2000, rivolgendo, in particolare, l’attenzione ai soggetti coinvolti nel traffico illecito degli stupefacenti: il dato più rilevante è rappresentato dalla quasi totale assenza di "minorenni coinvolti in fatti di droga" sul territorio di Piacenza
Flash alkylation for the identification of barbiturates in biological material
No full textThe gas chromatog. identification of barbiturates isolated from biol. material is not optimal, and due to their polar nature, it is difficult to obtain good resoln. on most columns. To improve resoln., flash alkylation appeared to be a reasonable alternative. Me, Et, and Bu derivs. were prepd. for various drugs found in the acid-neutral ext. and the Kovats retention indices (Ir) were detd. on SE-30, OV-17, and SP-2250. The Ir of the alkylated derivs. of the barbiturates are highly reproducible. One column and 2 alkylated derivs. can be used for the qual. anal. of barbiturates in exts. of biol. material, even when the Stas-Otto ext. is used
Il mercato della droga a Piacenza negli anni 1987-2000. Nota 1: casistica
No full textNel presente lavoro è stata effettuata una verifica dell’andamento del mercato clandestino della droga nella città di Pia-cenza nel corso degli anni 1987-2000. Tale verifica è stata condotta sia da un punto di vista del numero e della natura di re-perti sequestrati, sia per quanto concerne la composizione quali-quantitativa degli stupefacenti più diffusi, sia per quanto ri-guarda i soggetti coinvolti nel traffico illecito degli stupefacenti e la tipologia della sostanza loro sequestrata. Le conclusio-ni sul materiale stupefacente concordano con quanto dimostrato in un precedente studio ed evidenziano un incremento nell’uso della cocaina e dei derivati della Cannabis rispetto a quello dell’eroina
Systematic, generic, chemicotoxicological research in forensic toxicology. Part III. Comparison of IR and ΔIR obtained under programmed and isothermal temperature conditions
No full textGas-chromatog. data are presented on ∼350 drugs of forensic-toxicol. interest. These data are mainly the retention index (IR) values obtained on OV1 and OV17 columns under programmed and isothermal temp. conditions and the differences (ΔIR) obtained for the individual substances on the 2 columns. Use of the IR to express gas-chromatog. mobility gave well-reproducible data, with respect to both variations in temp. and comparison of values obtained from different labs. Taken alone, the ΔIR has low power for identifying a compd., but when used together with the IR values it constitutes a useful element for further narrowing the possibilities. The use of IR as a new approach to gas-chromatog. investigations in forensic toxicol. is suggested
La ricerca chimico tossicologica sistematica generica in tossicologia forense. II: considerazioni sull’uso degli indici di ritenzione e dei Δ IR nelle metodiche di saggio gas cromatografico
No full textValues for IR (retention index) and ΔIR (difference between the IR values of a given substance obtained on 2 columns of different polarity) were detd. for ∼50 compds. (mostly drugs) of interest in forensic toxicol., using isothermal conditions at various temps. (120-260°) and with programmed temp. cycles. The column packings used were OV1 and OV17 on Gas-Chrom Q. In general, the ΔIR values were as reproducible as the IR. Both showed little or no dependence on the exptl. conditions under which they were obtained. The ΔIR, which measures the polarity of a compd., may be a significant anal. tool in examg. homogeneous series of substances. The IR, however, esp. if detd. under programmed temp. conditions, may be of more value in detg. the genetic nature of heterogeneous compds. such as those of interest in toxicol. By the methods described here, compds. with IR values of the order of 3000 can be detd
Considerazioni sui metodi di determinazione gas cromatografica dell’alcoolemia per campionamento in fase gassosa
No full textManual and automatic gas-chromatog. methods for detg. blood EtOH [64-17-5] are described which involve anal. of the head space gas rather than of the liq. sample itself. Sec-BuOH is used as internal std. Both methods are simple, rapid, and precise. Because of the extremely low background noise assocd. with headspace sampling, very small amts. of volatile compds. other than EtOH can also be detected. The slope of the concn.-response plot did not vary significantly between solns. of EtOH in H2O and blood; the slope of the plot was slightly steeper with the automatic than with the manual method
Chemical-toxicological diagnosis in 16 cases of "intravenous narcotism" deaths
No full textThe chemical-toxicological diagnosis aspects involved in 16 cases of "intravenous narcotism" deaths are discussed. Liquids and biological materials were directly tested by RIA, GLC and TLC. According to the Authors, RIA is assumed to be more speedy and more sensitive than traditional chemical technics. Therefore RIA is proposed for quantitative determination of morfina and its derivates in biological liquids and viscera, previous the qualitative confirmation by the chemical tests
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