60 research outputs found
Exploring new boundaries for E-learning: Multicasting via satellite
No full textIn order to manage successful virtual distance learning programs (higher) education institutes should implement multimedia enriched learning materials which can be used in multiple environments/situations. This not only opens up new markets but also gives teachers and learners flexible access to rich online learning resources, leading to new pedagogic practice and giving students better preparation for the challenges of the workplace. However, several studies have reported frustrations with learners and educators due to technical problems, particularly the lack of broadband capacities. This paper describes an innovative IF' multicasting approach to take advantage of video and multimedia elements that are commonly difficult to deliver over the Internet. The Content Conductora, an open and modular framework, provides a platform for fully integrated provisioning and service management of multicast communications and allows the seamless integration of different types of hardware equipment and application software. As a result of the unique characteristics of this system, broad e-learning modalities become available and manageable.sponsorship: Goeman K., de Gruyter B., Mannaert Herwig , de Vos E..- Exploring new boundaries for e-learning: multicasting via satellite
, February 2003 - ISBN 0-7803-7661-7 - Papeete, 2003status: Publishe
Model-Driven Language Engineering: The ASMETA Case Study
Get PDFThis paper reports our experience in exploiting the metamodelling approach of model-driven language engineering to define a standard modelling language for the Abstract State Machines (ASMs) formal method, and develop a general framework (ASMETA) for a wide interoperability of ASM tools in a model-driven development context. We describe the requirements to fulfill and the design, implementation, validation, and tools development steps necessary to support such a language engineering life cycle. We finally discuss the benefits/limits of a model-driven language engineering approach with respect to traditional techniques primarily used for the same goal
Effect of renal impairment on the pharmacokinetics of prucalopride: a single- dose open-label Phase I study
No full textWilliam B Smith,1 Erik Mannaert,2 Tom Verhaeghe,2 René Kerstens,3 Lieve Vandeplassche,3 Vera Van de Velde41Volunteer Research Group and New Orleans Center for Clinical Research, The University of Tennessee Medical Center, Knoxville, TN, USA; 2Janssen Research and Development, a division of Janssen Pharmaceutica NV, Beerse, Belgium; 3Shire-Movetis NV, Turnhout, Belgium; 4Independent Consultant Clinical Pharmacokinetics, Princeton, NJ, USAObjective: To evaluate the pharmacokinetics of prucalopride in individuals with renal impairment (RI).Methods: This open-label Phase I study (ClinicalTrials.gov identifier: NCT01674192) enrolled men and women aged 18–75 years who were classified by renal function: normal renal function (creatinine clearance ≥ 80 mL/min/1.73 m2), mild RI (50–79 mL/min/1.73 m2), moderate RI (25–49 mL/min/1.73 m2), and severe RI (≤24 mL/min/1.73 m2). All received a single oral dose of prucalopride 2 mg.Results: Thirty-four individuals (normal renal function: 10; mild RI: 8; moderate RI: 7; severe RI: 9) received prucalopride. In all groups, maximum plasma concentration was reached within 2–4 hours. There was no significant difference in exposure (area under the plasma concentration–time curve from time zero to infinity) between participants with mild RI and those with normal renal function. However, area under the plasma concentration–time curve from time zero to infinity values were 1.5- and 2.3-fold higher (P = 0.002 and P < 0.001) in patients with moderate RI and severe RI, respectively, than in those with normal renal function. The proportion of total body clearance accounted for by renal clearance was significantly reduced in those with RI.Conclusion: Clinically meaningful reductions in renal clearance were seen in participants with severe RI, which supports a decrease from the standard dose of prucalopride 2 mg daily to 1 mg daily in these individuals.Keywords: renal impairment, pharmacokinetics, prucalopride, safet
A framework for characterizing usability requirements elicitation and analysis methodologies (UREAM)
No full textDedicated methodologies for the elicitation and analysis of usability requirements have been proposed in literature, usually developed by usability experts. The usability of these approaches by non-expert software engineers is not obvious. In this paper, the objective is to support developers
and managers in a software development project in deciding on which methodology to select, taking into account local strengths and weaknesses. We define a framework based on a set of criteria that allow for the comparison of methodologies
Process modeling-based assessment of software release planning, case study results and experiences
No full textIn the software industry, customer input often takes the form of improvement requests. Release planning is the process of making decisions about what new functionalities or changes will be implemented in which release of a software product. The purpose of this work in progress paper is to explore a new approach to assess and improve the release planning process in industrial software companies. The new approach consists of a combined application of software process modeling, assessment and improvement. This paper presents results and experiences from a case study in two industrial companies
Improving IT Infrastructures Representation: A UML Profile
Get PDFIT infrastructures are most times informally modeled. The resulting models are ambiguous to stakeholders, cannot be checked for validity, and therefore are unable to play their important role in design, deployment and maintenance activities. The main reason for such a poor state-of-the-art lies mainly in the absence of a modeling language capable of representing IT infrastructures at the required level of abstraction. Indeed, existing candidate languages are too abstract, as shown in this paper by reviewing their metamodels. The present paper mitigates this problem by proposing a UML profile to describe the semantics of an IT infrastructure
Improving IT infrastructures representation: A UML profile
Get PDFIT infrastructures are most times informally modeled. The resulting models are ambiguous to stakeholders, cannot be checked for validity, and therefore are unable to play their important role in design, deployment and maintenance activities. The main reason for such a poor state-of-the-art lies mainly in the absence of a modeling language capable of representing IT infrastructures at the required level of abstraction. Indeed, existing candidate languages are too abstract, as shown in this paper by reviewing their metamodels. The present paper mitigates this problem by proposing a UML profile to describe the semantics of an IT infrastructure.info:eu-repo/semantics/publishedVersio
A modular equality for Cameron-Liebler line classes in projective and affine spaces of odd dimension
Get PDFIn this article we study Cameron-Liebler line classes in PG and
AG, objects also known as boolean degree one functions. A
Cameron-Liebler line class is known to have a parameter that
depends on the size of . One of the main questions on
Cameron-Liebler line classes is the (non)-existence of these sets for certain
parameters . In particularly it is proven in [12] for , that the
parameter should satisfy a modular equality. This equality excludes about
half of the possible parameters. We generalize this result to a modular
equality for Cameron-Liebler line classes in PG, and AG
respectively. Since it is known that a Cameron-Liebler line class in AG
is also a Cameron-Liebler line class in its projective closure, we end this
paper with proving that the modular equality in AG is a stronger
condition than the condition for the projective case
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