1,721,323 research outputs found
Functionalization of phospha-thiahelicenes and application of their gold(I) complexes in enantioselective catalysis
No full textHelically chiral structures are known to display peculiar properties and applications in many fields, including asymmetric catalysis. However, both the synthesis of helical phosphorus ligands and their uses in enantioselective organometallic catalysis have been underdeveloped so far [1].
In the course of our studies on helical phosphane derivatives as potential chiral ligands in asymmetric organometallic catalysis [2], we have recently reported the synthesis of a new chiral phospha-thiahelicene based gold (I) complex, which is an excellent and selective pre-catalyst for the enantioselective cycloisomerization of N-tethered enynes [3].
On the basis of these very promising results we have effectively functionalized the phospha-thiahelicene scaffold to obtain new gold (I) complexes, which are then tested as pre-catalysts in other challenging enantioselective cycloisomerization reactions. 1. a) Y. Shen, C.-F. Chen, Chem. Rev. 2012, 112, 1463; b) P. Aillard , A. Voituriez, A. Marinetti, Dalton
Trans. 2014, 43, 15263.
2. a) S. Cauteruccio, A. Loos, A. Bossi, M. C. Blanco Jaimes, D. Dova, F. Rominger, S. Prager, A. Dreuw, E.
Licandro, A. S. K. Hashmi, Inorg. Chem. 2013, 52, 7995; b) K. Yavari, P. Aillard, Y. Zhang, F. Nuter, P.
Retailleau, A. Voituriez, A. Marinetti, Angew. Chem. Int. Ed. 2014, 53, 861.
3. P. Aillard, A. Voituriez, D. Dova, S. Cauteruccio, E. Licandro, and A. Marinetti, Chem. Eur. J. 2014, 20,
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Peptide nucleic acids as nucleic acid mimics: innovative modifications for improved properties
No full textDesign and sinthesis of new heterobifunctional linkers for the covalent binding of biomolecules onto superparamagnetic iron oxide nanoparticles(SPIONs)
No full textSuperparamagnetic Iron Oxide Nanoparticles (SPIONs) are attractive because of some peculiar properties such as selective separation of biomolecules and cells, automated DNA extraction, targeted gene delivery, use as magnetic resonance contrast agent (MRI), and magnetic field induced hyperthermia for cancer therapy.[1a-e] For application in biomedicine, SPIONs must be coated with appropriate biomolecules by a stable and easily tunable adsorption. Hence, the need to develop efficient synthetic strategies for the synthesis of novel bio-nanoconjugates is an important and appealing target.[2] The strategies used to anchor molecules onto these nanoparticles can involve passive noncovalent adsorption on the outer particle surface or the formation of a more stable covalent bond by using appropriate heterobifunctional linkers between the SPION and the biomolecule, in which one functional group of the linker binds specifically the nanoparticle, while the other reacts with the biomolecule in order to form the new nanoconjugate.
In this presentation, the discovery of a new functional group able to bind specifically the SPIONs is shown, leading to a new class of heterobifunctional linkers for SPIONs functionalization. First attempts in the conjugation of DNA/RNA mimics onto SPIONs were also shown demonstrating the validity of this new functionalization methodology.
[1] a)H. Gu, K. Xu, C. Xu and B. Xu, Chem Commun., 2006, 941; b) B. Yoza, A. Arakaki, K. Maruyama, H. Takeyama and T. Matsunaga, J. Biosci. Bioeng., 2003, 95, 21; c) M. Chorny, B. Polyak, I.S. Alferiev, K. Walsh, G. Friedman and R.J. Levy, FASEB J., 2007, 21, 2510; d) M.G. Harisinghani, J. Barentsz, P.F. Hahn, W.M. Deserno, S. Tabatabaei, C.H. van de Kaa, J. de la Rosette and R. Weissleder, N. Engl. J. Med., 2003, 348, 2491; e) J.P. Fortin, C. Wilhelm, J. Servais, C. Menager, J.C. Bacri and F. Gazeau, J. Am. Chem. Soc., 2007, 129, 2628.
[2] G. Prencipe, S. Maiorana, P. Verderio, M. Colombo, P. Fermo, E. Caneva, D. Prosperi and E. Licandro, Chem Commun., 2009, 6017
Covalent binding of biomolecules onto superparamagnetic iron oxide nanoparticles (SPIONs) : design and synthesis of new heterobifunctional linkers
No full textSuperparamagnetic Iron Oxide Nanoparticles (SPIONs) are attractive because of some peculiar properties such as selective separation of biomolecules and cells, automated DNA extraction, targeted gene delivery, use as magnetic resonance contrast agent (MRI), and magnetic field induced hyperthermia for cancer therapy.[1a-e] For application in biomedicine, SPIONs must be coated with appropriate biomolecules by a stable and easily tunable adsorption. Hence, the need to develop efficient synthetic strategies for the synthesis of novel bio-nanoconjugates is an important and appealing target.[2] The strategies used to anchor molecules onto these nanoparticles can involve passive noncovalent adsorption on the outer particle surface or the formation of a more stable covalent bond by using appropriate heterobifunctional linkers between the SPION and the biomolecule, in which one functional group of the linker binds specifically the nanoparticle, while the other reacts with the biomolecule in order to form the new nanoconjugate.
In this contribution, the discovery of a new functional group able to bind specifically the SPIONs is shown, leading to a new class of heterobifunctional linkers for SPIONs functionalization.
References:
1 a)H. Gu, K. Xu, C. Xu and B. Xu, Chem Commun., 2006, 941; b) B. Yoza, A. Arakaki, K. Maruyama, H. Takeyama and T. Matsunaga, J. Biosci. Bioeng., 2003, 95, 21; c) M. Chorny, B. Polyak, I.S. Alferiev, K. Walsh, G. Friedman and R.J. Levy, FASEB J., 2007, 21, 2510; d) M.G. Harisinghani, J. Barentsz, P.F. Hahn, W.M. Deserno, S. Tabatabaei, C.H. van de Kaa, J. de la Rosette and R. Weissleder, N. Engl. J. Med., 2003, 348, 2491; e) J.P. Fortin, C. Wilhelm, J. Servais, C. Menager, J.C. Bacri and F. Gazeau, J. Am. Chem. Soc., 2007, 129, 2628.
2 G. Prencipe, S. Maiorana, P. Verderio, M. Colombo, P. Fermo, E. Caneva, D. Prosperi and E. Licandro, Chem Commun., 2009, 6017
Luminescent conjugates between dinuclear rhenium(I) complexes and peptide nucleic acids (PNA) for cell imaging and DNA targeting
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