628 research outputs found
762435_supp_mat – Supplemental material for LIBERTI: A SMART study in plastic surgery
No full textSupplemental material, 762435_supp_mat for LIBERTI: A SMART study in plastic surgery by Jonathan C Hibbard, Jonathan S Friedstat, Sonia M Thomas, Renee E Edkins, C Scott Hultman and Michael R Kosorok in Clinical Trials</p
The Innocent Defendant\u27s Dilemma: An Innovative Empirical Study of Plea Bargaining\u27s Innocence Problem
No full textIn this Article, Professors Dervan and Edkins discuss a recent psychological study they completed regarding plea bargaining and innocence. The study, involving dozens of college students and taking place over several months, revealed that more than half of the innocent participants were willing to falsely admit guilt in return for a benefit. These research findings bring significant new insights to the long-standing debate regarding the extent of plea bargaining’s innocence problem. The Article also discusses the history of bargained justice and examines the constitutional implications of the study’s results on plea bargaining, an institution the Supreme Court reluctantly approved of in 1970 in return for an assurance that it would not be used to induce innocent defendants to falsely admit guilt
The Innocent Defendant\u27s Dilemma: An Innovative Empirical Study of Plea Bargaining\u27s Innocence Problem
No full textIn this Article, Professors Dervan and Edkins discuss a recent psychological study they completed regarding plea bargaining and innocence. The study, involving dozens of college students and taking place over several months, revealed that more than half of the innocent participants were willing to falsely admit guilt in return for a benefit. These research findings bring significant new insights to the long-standing debate regarding the extent of plea bargaining’s innocence problem. The Article also discusses the history of bargained justice and examines the constitutional implications of the study’s results on plea bargaining, an institution the Supreme Court reluctantly approved of in 1970 in return for an assurance that it would not be used to induce innocent defendants to falsely admit guilt
Instructing the Heavenly King: Joseph Edkins’s Mission to Correct the Theology of Hong Xiuquan
No full textThis paper examines Joseph Edkins’ failed attempt to correct the theology of Hong Xiuquan during his trip to Nanjing in March and April 1861. Through his debates with individual rebels and his written exchange with Hong, Edkins learned that the Taipings were unwilling to accept ‘orthodox’ teachings and scriptural interpretations that conflicted with their established belief system. Challenging exclusionary and pathologising discourses, the paper shows that Hong’s response to Edkins’ efforts was rooted not in his ‘irrational’ modes of thinking, but in his desire to preserve both his revelation-based worldview and the personal authority that it legitimised
Neonatal seizures and Long QT Syndrome: A cardiocerebral channelopathy?
No full textWe identified a patient with electrophysiologically verified neonatal long QT syndrome (LQTS) and neonatal seizures in the presence of a controlled cardiac rhythm. To find a cause for this unusual combination of phenotypes, we tested the patient for mutations in seven ion channel genes associated with either LQTS or benign familial neonatal seizures (BFNS). Comparative genome hybridization (CGH) was done to exclude the possibility of a contiguous gene syndrome. No mutations were found in the genes (KCNQ2, KCNQ3) associated with BFNS, and CGH was negative. A previously described mutation and a known rare variant were found in the LQTS-associated genes SCN5A and KCNE2. Both are expressed in the brain, and although mutations have not been associated with epilepsy, we propose a pathophysiologic mechanism by which the combination of molecular changes may cause seizures.Sarah E. Heron, Marta Hernandez, Caitlin Edwards, Edward Edkins, Floor E. Jansen, Ingrid E. Scheffer, Samuel F. Berkovic and John C. Mulle
The effect of atmospheric pressure on Snowball Earth deglaciation
No full textThe most common explanation for the escape from a Snowball Earth state involves, among other factors, a strong greenhouse effect caused by a large partial pressure of CO2. This leads to an increase in surface pressure, which most models do not account for. With a higher surface pressure, pressure broadening increases, and convection reaches a deeper layer, both of which result in higher surface temperatures. The latter mechanism, which has not previously been reported, is found to be a greater source of warming than pressure broadening in the normal range of CO2 partial pressures at the point of deglaciation
Cartografias e governança do desaparecimento de migrantes na América Central e México
No full textEste artigo analisa o desaparecimento de migrantes na América Central e México por meio de uma abordagem crítica da cartografia, focando nas representações visuais produzidas pela Organização Internacional para as Migrações, o Servicio Jesuita a Migrantes e o Equipo Argentino de Antropología Forense. O estudo examina como essas instituições utilizam mapas para documentar e moldar narrativas sobre o desaparecimento e como isso afeta a governança do tema. A fundamentação teórica se baseia nas reflexões de Jenny Edkins sobre o desaparecimento como processo político que apaga a identidade das vítimas e na crítica à desumanização dos migrantes por representações quantitativas. A análise mostra que, embora forneçam visibilidade, as cartografias reforçam estruturas de controle migratório, enquanto movimentos sociais e familiares criam suas próprias representações para resistir à invisibilização. Conclui-se que, além das soluções técnicas, é necessária uma governança mais humanizada e colaborativa para lidar com a coThis paper analyzes the disappearance of migrants in Central America and Mexico through a critical approach to cartography, focusing on the visual representations produced by the International Organization for Migration, the Jesuit Migrant Service, and the Argentine Forensic Anthropology Team. The study examines how these institutions use maps to document and shape narratives about disappearances and how this affects the governance of the issue. The theoretical foundation is based on Jenny Edkins’ reflections on disappearance as a political process that erases the identity of victims and on the critique of the dehumanization of migrants through quantitative representations. The analysis shows that, although they provide visibility, cartographies reinforce structures of migration control, while social and family movements create their own representations to resist invisibility. It is concluded that, in addition to technical solutions, more humanized and collaborative governance is needed to deal with the comp
Teneurins in development and disease
No full textThe teneurins are a novel type II transmembrane protein family
originally discovered in Drosophila and highly conserved between invertebrates
and vertebrates. Studies in invertebrates suggest important functions for the
teneurins in many processes during development. However, still very little is
known about the biological function and mechanism of action of the vertebrate
teneurin family, which consists of four paralogs called teneurin-1 to -4.
In the first part of my thesis, I analyzed the expression pattern and
signaling mechanism of teneurin-1 during chick development. Teneurin-1 was
prominently expressed in specific regions of the brain, and often complementary
to teneurin-2. The presence of teneurin-1 and -2 in interconnected regions of
the brain implies a role for teneurins in the establishment of appropriate
neuronal connectivity. Using a novel antibody recognizing the teneurin-1
intracellular domain (ICD), N-terminal processing products were detected and
nuclear staining was observed in specific neurons and tissues. This provides
evidence for our working hypothesis, according to which teneurins can be
processed by a mechanism called regulated intramembrane proteolysis,
resulting in the release and nuclear translocation of the ICD. Similar results
were obtained for teneurin-4 during chick development.
In the second part of my thesis, I investigated the implication of
teneurins in two human diseases.
X-linked mental retardation: Teneurin-1 was analyzed as an X-linked
mental retardation (XLMR) candidate gene in 23 XLMR patients. No mutation
that is likely to cause the disease was found the coding region or splice sites of
the teneurin-1 gene in these patients.
Brain tumors: Teneurin-4 was found to be upregulated in a microarray
analysis of human brain tumors including astrocytomas, oligodendrogliomas and
glioblastomas (GBMs). The overexpression of teneurin-4 was confirmed on
protein level in brain tumor lysates. Immunohistochemistry (IHC) revealed
strong staining around tumors cells in some brain tumors whereas in others
teneurin-4 restricted to blood vessels
Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype-phenotype correlation
No full textFirst published online 14 October 2009. © 2010 European Society of Human GeneticsMental retardation (MR) is characterized by cognitive impairment with an IQ A) in a published family with nonsyndromic MR, MRX13. This change occurs in a highly conserved amino acid, with proline (P) being substituted by threonine (T) (p.P554T). [corrected] Functional analysis shows that this amino-acid substitution compromises both tri- and didemethylase activity of the JARID1C protein. We conclude that the two novel changes impair JARID1C protein function and are disease-causing mutations in these families.Sinitdhorn Rujirabanjerd, John Nelson, Patrick S. Tarpey, Anna Hackett, Sarah Edkins, F Lucy Raymond, Charles E. Schwartz, Gillian Turner, Shigeki Iwase, Yang Shi, P. Andrew Futreal, Michael R. Stratton, Jozef Gec
Sovereign-less subject and the possibility of resistance
No full textThis article explores exclusionary practices of contemporary politics and alternative forms of resistance. It starts off explaining how Giorgio Agamben's theory can be understood in the context of resistance. In so doing, it turns to the arguments put forward by Edkins and Pin-Fat. In their article 'Through the Wire', they identify two forms of resistance. Drawing on Agamben's thought: refusal and the assumption of bare life. This article argues that these two forms are not sufficient for thinking resistance. This is so because of a gap in Agamben's thought and the way Edkins and Pin-Fat read him. In order to explore resistance in a more fruitful way, the article critiques Edkins and Pin-Fat's conclusions on the understanding bare life as a form of resistance; it amends Agamben's account by explaining the move from bare life to whatever being, and ultimately, the article finds whatever being as a fruitful way of understanding resistance on the example of Tiananmen. At the end I conclude that the Tiananmen protest successfully challenged the sovereign power from the position of in-between. © The Author(s), 2009
- …
