950 research outputs found
The Burger Court and Labor Law: The Beat Goes On--Marcato
No full textThis Article analyzes many of the major labor law decisions of the Burger Court and their impact on organized labor. The author compares the Court\u27s methodology with that of the Warren Court and asserts that the Burger Court has, in many instances, simply expanded on themes developed by its predecessor. The author further discusses areas in which the Burger Court has broken new ground and concludes that the Burger Court has accelerated the pendulum against the interests of organized labor
Angiotensin II and the vascular phenotype in hypertension
No full textHypertension is associated with vascular changes characterised by remodelling, endothelial dysfunction and hyperreactivity. Cellular processes underlying these perturbations include altered vascular smooth muscle cell growth and apoptosis, fibrosis, hypercontractility and calcification. Inflammation, associated with macrophage infiltration and increased expression of redox-sensitive pro-inflammatory genes, also contributes to vascular remodelling. Many of these features occur with ageing, and the vascular phenotype in hypertension is considered a phenomenon of ‘premature vascular ageing’. Among the many factors involved in the hypertensive vascular phenotype, angiotensin II (Ang II) is especially important. Ang II, previously thought to be the sole effector of the renin–angiotensin system (RAS), is converted to smaller peptides [Ang III, Ang IV, Ang-(1-7)] that are biologically active in the vascular system. Another new component of the RAS is the (pro)renin receptor, which signals through Ang-II-independent mechanisms and might influence vascular function. Ang II mediates effects through complex signalling pathways on binding to its G-protein-coupled receptors (GPCRs) AT<sub>1</sub>R and AT<sub>2</sub>R. These receptors are regulated by the GPCR-interacting proteins ATRAP, ARAP1 and ATIP. AT<sub>1</sub>R activation induces effects through the phospholipase C pathway, mitogen-activated protein kinases, tyrosine kinases/phosphatases, RhoA/Rhokinase and NAD(P)H-oxidase-derived reactive oxygen species. Here we focus on recent developments and new research trends related to Ang II and the RAS and involvement in the hypertensive vascular phenotype
METAPHOR ANALYSIS OF TWO INTERNATIONAL BURGER FRANCHISES
No full textBurger King and McDonald's are the two largest burger franchises globally, characterized by the number of restaurants owned. Burger King and McDonald's competition can be seen from how the two companies penetrate the global market. From the advertising context, both companies innovatively and persuasively develop consumer awareness on the one hand, and on the other hand, there are attempts to weaken competitors. This research is directed to analyze the (multimodal) metaphor used by the two companies to promote burger products. Qualitative research on pictorial advertisements was carried out in stages through several phases, which included descriptions of social, historical, and cultural contexts, identification of visual elements, identification of verbal elements, and analysis that elaborated on the three phases. The analysis shows competition between Burger King's and McDonald's advertisements. Multimodal metaphor analysis comprehensively shows that both companies use visual and verbal elements to increase consumers' awareness of existing or future products. Both companies tend to use personification to build corporate identity and the products offered and will be promoted. This research still has many weaknesses. The author suggests that the analysis focus on linguistic elements and extra-linguistic elements, such as motion, images, and sounds
sj-tif-1-tpx-10.1177_01926233231191128 – Supplemental material for Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
No full textSupplemental material, sj-tif-1-tpx-10.1177_01926233231191128 for Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology by Alex A. Gutsol, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert and Kevin D. Burns in Toxicologic Pathology</p
sj-tif-2-tpx-10.1177_01926233231191128 – Supplemental material for Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
No full textSupplemental material, sj-tif-2-tpx-10.1177_01926233231191128 for Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology by Alex A. Gutsol, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert and Kevin D. Burns in Toxicologic Pathology</p
sj-tif-3-tpx-10.1177_01926233231191128 – Supplemental material for Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
No full textSupplemental material, sj-tif-3-tpx-10.1177_01926233231191128 for Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology by Alex A. Gutsol, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert and Kevin D. Burns in Toxicologic Pathology</p
sj-tif-4-tpx-10.1177_01926233231191128 – Supplemental material for Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
No full textSupplemental material, sj-tif-4-tpx-10.1177_01926233231191128 for Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology by Alex A. Gutsol, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert and Kevin D. Burns in Toxicologic Pathology</p
sj-docx-5-tpx-10.1177_01926233231191128 – Supplemental material for Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
No full textSupplemental material, sj-docx-5-tpx-10.1177_01926233231191128 for Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology by Alex A. Gutsol, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert and Kevin D. Burns in Toxicologic Pathology</p
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