55,226 research outputs found

    Letter Concerning S. 1658

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    Letter: From Frederick G. Dutton, to Mr. Gordon, April 2, 196

    Letter Replying to Request to Comment on S. 1658

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    Letter: From Frederick G. Dutton, to Mr. Gordon, April 3, 196

    The Origin of G. S. hominis, cardinis, ordinis (G.S. of -N Stem -ōnis vs. -inis)

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    The paper deals with an oddity in Latin morphology: the fact that a number of nouns (margō, ōrdō, cardō, homō and nēmō), in spite of being masculine, have, contrary to the general tendency, the G. S. in -inis instead of -ōnis. Some of the nouns (margō, ōrdō, cardō), unlike the other masculine nouns, retained their original G. S. form in -inis (which traces back to Old Latin *-ones) presumably due to analogy with the large group of feminine nouns in -dō, -gō because they have the same consonant at the end of stem. The G. S. of another exception, homō, is explained by analogy with the neuter nouns of the type nomen, nominis. The author also argues that the majority of G. S.-ōnis of feminina abstracta in -iō (type nātiō, -ōnis) can be explained phonologically without referring to their gender. Refs 8

    G band atmospheric radars: New frontiers in cloud physics

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    Clouds and associated precipitation are the largest source of uncertainty in current weather and future climate simulations. Observations of the microphysical, dynamical and radiative processes that act at cloud scales are needed to improve our understanding of clouds. The rapid expansion of ground-based super-sites and the availability of continuous profiling and scanning multi-frequency radar observations at 35 and 94 GHz have significantly improved our ability to probe the internal structure of clouds in high temporal-spatial resolution, and to retrieve quantitative cloud and precipitation properties. However, there are still gaps in our ability to probe clouds due to large uncertainties in the retrievals. The present work discusses the potential of G band (frequency between 110 and 300 GHz) Doppler radars in combination with lower frequencies to further improve the retrievals of microphysical properties. Our results show that, thanks to a larger dynamic range in dual-wavelength reflectivity, dual-wavelength attenuation and dual-wavelength Doppler velocity (with respect to a Rayleigh reference), the inclusion of frequencies in the G band can significantly improve current profiling capabilities in three key areas: boundary layer clouds, cirrus and mid-level ice clouds, and precipitating snow. © 2014 Author(s)

    [Letter to J. G. O'Rielly Regarding Firefighting - October 15, 1943]

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    Letter to J. G. O'Rielly of W. S. Darley & Company discussing the champion type "H" pump and an enclosed list of fire chiefs located throughout the Middle East. The author of this letter recommends that Mr. Rielly send photographs and the highest pressure recorded on this pump to Captain James C. Thompson

    The G-protein-coupled receptor APJ is expressed in the second heart field and regulates Cerberus-Baf60c axis in embryonic stem cell cardiomyogenesis

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    Aims: Mammalian cardiomyogenesis occurs through a multistep process that requires a complex network of tightly regulated extracellular signals, which integrate with the genetic and epigenetic machinery to maintain, expand, and regulate the differentiation of cardiac progenitor cells. Pluripotent embryonic stem cells (ESCs) recapitulate many aspects of development, and have provided an excellent opportunity to dissect the molecular mechanisms underlying cardiomyogenesis, which is still incompletely defined. Methods and results: We provide new in vivo evidence thatthe G-protein-coupled receptor angiotensin receptor-like 1(Apj) is expressed in the mesodermal cells of the second heart field, a population of cardiac progenitors that give rise to a major part of the definitive heart. By combining loss-and-gain of function studies in mouse ESCs, we show that Apj (i) controls the balance between proliferation and cardiovascular differentiation, (ii)regulatesthe Nodal/Bone Morphogenetic Protein antagonist Cerberus and the Baf60c/Smarcd3 subunit of the Brg1/Brm-associated factors (BAF) chromatin-remodelling complex. Conclusion: We propose a model in which Apj controls a regulatory Cerberus-Baf60c pathway in pluripotent stem cell cardiomyo-genesis, and speculate that this regulatory circuit may regulate cardiac progenitor cell behaviour. © The Author 2013

    G (A, B)-labeling of cacti over groups

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    © 2016 Author(s). Let G be a group with nonempty subsets A and B. The graph G(A, B) is the simple graph obtained by deleting all loops from the graph whose vertex set is A and where vertices x and y are adjacent if and only if there is a b B such that xb = y or yb = x. In this paper, we present realizations of some cacti as G(A, B)\u27s

    Climate change, biodiversity loss and mental health: a global perspective

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    Climate change can have various psychopathological manifestations which have been more actively addressed by scientific research only in recent years. Indeed, extreme weather events and environmental changes have been shown to be associated with a range of mental health problems. Following the destruction of ecosystems, biodiversity loss can cause mental distress and emotional responses, including so-called 'psychoterratic' syndromes arising from negatively felt and perceived environmental change. Studies investigating relationships between biodiversity and mental health reveal a complex landscape of scientific evidence, calling for a better understanding of this challenging issue. Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists

    Kinetics of Spontaneous and EF-G-Accelerated Rotation of Ribosomal Subunits

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    SummaryRibosome dynamics play an important role in translation. The rotation of the ribosomal subunits relative to one another is essential for tRNA-mRNA translocation. An important unresolved question is whether subunit rotation limits the rate of translocation. Here, we monitor subunit rotation relative to peptide bond formation and translocation using ensemble kinetics and single-molecule FRET. We observe that spontaneous forward subunit rotation occurs at a rate of 40 s−1, independent of the rate of preceding peptide bond formation. Elongation factor G (EF-G) accelerates forward subunit rotation to 200 s−1. tRNA-mRNA movement is much slower (10–40 s−1), suggesting that forward subunit rotation does not limit the rate of translocation. The transition back to the non-rotated state of the ribosome kinetically coincides with tRNA-mRNA movement. Thus, large-scale movements of the ribosome are intrinsically rapid and gated by its ligands such as EF-G and tRNA
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