115,204 research outputs found
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
Letter from W. T. Johnson to S. J. Dunn
No full textLetter from W. T. Johnson to S. J. Dunn, thanking him for serving as a Workshop Committee Director at the Vocational Agriculture Teachers\u27 Conference
Dunn, R T, 213028
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/382955Surname: DUNN. Given Name(s) or Initials: R T. Military Service Number or Last Known Location: 213028. Missing, Wounded and Prisoner of War Enquiry Card Index Number: SEA-1790.222602
Item: [2016.0049.15248] "Dunn, R T, 213028
Dunn, W T, VX2192
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/382989Surname: DUNN. Given Name(s) or Initials: W T. Military Service Number or Last Known Location: VX2192. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 31602.222636
Item: [2016.0049.15282] "Dunn, W T, VX2192
Christobel Dunn
No full text"Christobel Dunn daughter of Archibald T.R. Halls Supervisor of Telegraph Killed Feb 19. 1942.
Oral history interview with Dana Becker Dunn
No full textTranscript, 43 pp.Dana Becker Dunn graduated from a rural Illinois high school, then attended Southern Illinois University as a math major taking numerous computing courses and graduating in 1972. She joined Bells Labs as one of the last STA ‘courtship’ hires, completing a master’s in electrical engineering and computer science from Northwestern University. Her technical career began in operating systems programming, with a specialty in relational databases; then she was promoted into supervisory positions in the AT&T headquarters in New Jersey. As a Sloan Fellow she completed an executive MBA at MIT in 1984 then went to work for AT&T information systems division. Among her managerial responsibilities were connecting marketing and technical staffs; overseeing large operational groups in marketing and communications; and in 1994 separating Lucent Technologies from AT&T. She retired in 2001 as an officer of Avaya. She reflects on the transformation of women’s issues within AT&T, including a suggestion that with overt forms of discrimination largely banished, it may have ‘gone underground’ and be more difficult to locate.
This material is based on work funded by the Alfred P. Sloan Foundation award B2014-07 “Tripling Women’s Participation in Computing (1965-1985).”Alfred P. Sloan Foundation award B2014-07 “Tripling Women’s Participation in Computing (1965-1985).”Dunn, Dana Becker. (2016). Oral history interview with Dana Becker Dunn. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/188485
Humanics- A Message of Hope - Dr. Edward T. Dunn (c. 1983)
No full textThis document titled “Humanics- A Message of Hope” is the Humanics Lecture that was given at Springfield College by the tenth Distinguished Professor of Humanics, Dr. Edward T. Dunn, on May 5, 1983.
Dr. Edward T. Dunn coached football and taught physical education at Springfield College for twenty-nine years. He used the sport fields and arenas as well as the classroom to pass on skills, attitudes, social consciousness, and humane consideration to generations of students who, because of his “go get 'em” enthusiasm, whatever the odds, nicknamed him “Tiger.” At the conclusion of his varsity football coaching days Dunn went back to school and earned a Doctorate at Boston University as a Health Educator. During his year as Tenth Distinguished Springfield Professor of Humanics, Dr. Dunn brought guest speakers to campus to discuss ethical issues, he collaborated with his predecessor Dr. Sims on a study of the quality of academic life on campus, and he explained his own summary of his ideas about Humanics.
Dunn begins his lecture by stating that his view of education is based on two principles: that education should “help” rather than “make” each person become something, and that the scope of education should be broad instead of specialized. He quotes: “There is only one subject matter for education and this is life, in all its manifestations…At best, it should prepare a person for a lifetime of learning.” Dunn states that the Springfield College education, which we say is based on a Humanics attitude or philosophy, is also founded on a broad approach. Dunn believes the fundamental principle behind a Humanics education is to help each person, who comes in contact with its influence, to develop a better attitude toward life, as well as a better quality of life-style through the development of his/her total person in the multi-dimensions of the spirit, mind and body. He goes on to explain that high-level wellness, which is used in present day literature, is the concept of "wholistic" health and is the model for the Humanics concept of education. Dunn says that the Humanics philosophy Springfield College can be carried on by teachers who try to live lives directed toward high-level wellness which will serve as building blocks in the Humanics model for further development in future generations. Dunn believed these teachers would act as the prototypes who would illustrate Henry Paar's definition of a person doing Humanics as, “One who practices uncelebrated humane contacts.” Examples of such people at Springfield College, according to Dunn, are Jesse Parks, Barbara Jensen and Diane Potter. Dunn finishes his lecture with a brief glimpse into the examination of his own life as well as a thank you to the faculty that elected him for the Distinguished Professor of Humanics position.Humanics is a word that has a special meaning in the history and philosophy of Springfield College, as well as in the college’s motto of “Spirit, Mind, and Body.” The Oxford English Dictionary defines Humanics as, “the subject or study of human affairs or relations, especially of the human element of a problem or situation as opposed to the mechanical.” In 1962, Dr. Glenn Olds, President of Springfield College at the time, began to wonder why this name was given to the intended philosophy of the college by Dr. Laurence Locke Doggett, Springfield College’s first full-time president. Olds acknowledged that the practices of the faculty were in large part consistent with the Humanics philosophy, but he believed that a more self-conscious application would improve chances of its continuity and survival. To ensure this, a Distinguished Professor of Humanics position was created at the college, first filled by Dr. Seth Arsenian from 1966-1969. The purpose of this position was to catalyze a renewal of consciousness in the philosophy. This was done by annually mandating the Distinguished Professor of Humanics to give a Humanics lecture on the definition of Humanics and what the concept means to them. Arsenian started this tradition in 1967 with his speech titled, “The Meaning of Humanics,” in which he described the concept as a set of ideas, values, and goals that make our college distinct from other colleges and make commitment and unity toward commonly sought goals possible
The Thomas Tribune
No full textWeekly newspaper from Thomas, Oklahoma that includes local, state, and national news along with advertising
- …
