401 research outputs found
Yannis Psycharis: Τα σκουλαρίκια &Το παιδί και τα δύο πουλάκια
No full textThis bachelor thesis consists of four parts - biography of the author Yannis Psycharis, the process of Greek language question, translation of two Greek tales into Czech and its commentary. The translated tales are a part of the collection of tales Στον ίσκιο του πλατάνου: δεκαπέντε διηγήματα, specifically Τα σκουλαρίκια a Το παιδί και τα δύο πουλάκια. The collection of tales was published by Greek Publisher Εστία in edition J. Gamber and was written by Yannis Psycharis. The commentary consists of an analysis of the source text and the typology of translation problems
Archaeology and the politics of pedagogy
No full textIt is argued here that pedagogy, rather than being a passive process of delivery, is part of the field of cultural politics, a contested domain, a public sphere where knowledges, views and perceptions on the past and the present are debated and contested, or valorized, reproduced and legitimized. Recent archaeological theory has neglected the field of pedagogy, which, as a result, has been largely colonized by the instrumentalist discourse, in its new, market-oriented reincarnation. This dominant view of archaeological pedagogy is presented in objectified, neutral terms as the natural, inevitable course of affairs: it has become the 'doxic' regime that is presented as being beyond criticism at its core, save for peripheral managerial points. Archaeology, however, has the ability to undermine this objectified discourse by showing the contingency, historicity, and the inevitably transient and unstable nature of the present-day pedagogical regime in archaeology. Current instrumentalist pedagogy, despite its dominance, does not go unchallenged. One way of challenging it is by devising pedagogical processes that create a space for critical reflection, reconnect subjectivity and experience with knowledge, and allow students not only to understand the material and social processes that generate and reproduce their own subjectivity, but also question and even transform these processes and conditions. Student-centred journals that promote critical reflexivity are an example of one such pedagogic process. This paper presents the experience of the author in using such a device in the teaching of a course on the archaeology and anthropology of eating and drinking
After the Fact; Precisely Now (translated by Edmund Keeley)
No full textYannis Ritsos, the distinguished Greek poet, has published many volumes, including Parentheses and The Distant.Edmund Keeley of Princeton, New Jersey is the author of a recent novel, A Wilderness Called Peace, and translator of a selection of Ritsos\u27s poems, Exile and Return, to be published this fall by The Ecco Press
Une pleureuse Crétoise
No full textConcerning one of La Canée's fragmentary funeral steles that he ascribes to an Attic or in Attic style workshop set up in Western Crete, the author analyses the changed way in which the mourner's topic is discussed in the IVth cent. B.C.À propos d'une stèle funéraire fragmentaire de La Canée qu'il attribue à un atelier attique ou de formation attique installé en Crète occidentale, l'A. analyse l'esprit changé dans lequel le thème de la pleureuse est traité au IVe siècle av. J.-C.Papaoikonomou Yannis. Une pleureuse Crétoise. In: Revue des Études Anciennes. Tome 85, 1983, n°1-2. pp. 5-14
Optimization of genomic data analysis in rare diseases
No full textLes analyses pangénomiques d’exome et de génome ont permis d’augmenter considérablement le rendement diagnostique des maladies rares d’origine génétique au cours des dernières années, mais plus de 50 % des patients restent en impasse diagnostique (Wright, FitzPatrick, et Firth 2018). Pour les patients qui bénéficient d’un diagnostic, le délai d’obtention reste long, dépassant 5 ans pour 25 % des patients (Ministère des Solidarités et de la Santé 2019). L’absence de diagnostic ou le délai avant celui-ci sont une réelle perte de chance pour le patient et les familles, en termes de prise en charge de soin, mais également en termes de prise en charge sociale.L’objectif de la thèse est d’optimiser l’analyse de données génomiques dans les maladies rares, par l’implémentation de nouvelles approches, qu’elles soient organisationnelles, biologiques ou bioinformatiques, en vue d’obtenir un diagnostic plus rapidement dans un contexte d’urgence, et d’augmenter le rendement diagnostique. La thèse est divisée en trois axes d’optimisation.Le premier axe, l’optimisation organisationnelle, consiste en l’étude Fastgen, qui évalue la faisabilité de l’analyse accélérée de génomes short read en trio chez des enfants en réanimation ou soins intensifs, nécessitant un diagnostic génétique précoce pour orienter leur prise en charge. L’objectif était d’obtenir un résultat en moins de 45 jours. Un séquençage de génomes en trio a été réalisé chez 37 familles, conduisant à un diagnostic moléculaire chez 18/37 (49 %) enfants, avec une durée médiane de rendu de résultat de 42 jours.Le deuxième axe, l’optimisation biologique, consiste en l’étude de la cohorte unsolved cases du projet Solve-RD, qui vise à réduire l’impasse diagnostique par la réanalyse de données d’exomes de patients sans diagnostic et par la mise à disposition des données génomiques aux équipes du projet. Les données de 3576 exomes (1522 cas index et 2054 parents) ont été réanalysées selon une stratégie low-hanging fruit qui vise à rechercher les variations déjà rapportées dans ClinVar comme étant pathogènes ou probablement pathogènes. La réanalyse a permis d’identifier les variations causales chez 59 patients (3,9 %), dont 9 pour lesquels nous présentons les raisons de l’absence de diagnostic au moment de la première analyse et les leçons à en tirer.Le partage des données au sein de Solve-RD a facilité la construction d’une cohorte qui a permis d’établir la responsabilité du gène YWHAE dans un trouble du neurodéveloppement avec ou sans anomalies cérébrales, ce qui a mené à un diagnostic chez 7 sujets avec des variations perte de fonction de ce gène.Le troisième axe, l’optimisation bioinformatique, consiste en l’implémentation d’un pipeline utilisant les meilleurs outils de génotypage d’expansions de microsatellites à partir de données de génome short read, dans le but d’établir de nouveaux diagnostics. Nous avons évalué les 10 principaux outils de la littérature, en avons conservé 4 et les avons testés sur 23 locus impliqués en pathologie humaine sur notre cohorte de 323 génomes de sujets atteints de troubles du neurodéveloppement. Le pipeline développé a mené à l’identification d’une expansion de microsatellites pathologique pouvant prédisposer à une maladie neurodégénérative, considérée comme une donnée incidente car sans lien avec le phénotype du patient.Notre stratégie d’optimisation de l’analyse des données génomiques dans les maladies rares s’avère efficace : elle a permis de réduire l’errance diagnostique chez des enfants dans un contexte d’urgence et d’augmenter le rendement diagnostique du séquençage de l’exome et du génome short read par le développement de nouvelles stratégies d’analyse, de réanalyse et par le partage de données à large échelle.Exome and genome sequencing have significantly increased the diagnostic yield of rare genetic diseases in recent years, but more than 50% of patients remain in a diagnostic deadlock (1). For patients who are diagnosed, the time to obtain a diagnosis remains long, over 5 years for 25% of patients (2). The absence of diagnosis or the delay before it is made is a loss of chance for the patient and the families, in terms of care management, as well as in terms of social management.The objective of this work is to optimize the analysis of genomic data in rare diseases by implementing new approaches, whether they be organizational, biological or bioinformatics, to obtain a faster diagnosis in an emergency context and to increase the diagnostic yield. The thesis is divided into three optimization axes.The first axis deals with organizational optimization and consists of the Fastgen study, which assesses the feasibility of accelerated short read trio-genome analysis in children in intensive care unit requiring an early genetic diagnosis to guide their care management. The objective was to obtain a result in less than 45 days. Trio-genome analysis was performed in 37 families and led to a molecular diagnosis in 18/37 (49%) children, with a median time to result of 42 days.The second axis deals with biological optimization and consists of the study of the unsolved cases cohort of the Solve-RD project, which aims to reduce the diagnostic deadlock by reanalyzing exome data from patients without a diagnosis and by sharing genomic data with the project collaborators. Data from 3576 exomes (1522 index cases and 2054 relatives) were reanalyzed using a low-hanging fruit strategy that aims to search for variants already reported as pathogenic or probably pathogenic in ClinVar. The reanalysis identified causative variants in 59 patients (3.9%), including 9 for whom we present the reasons of the failure of the previous analyses and lessons learned.Data sharing within the Solve-RD consortium facilitated the construction of a cohort that established the involvement of the YWHAE gene in a neurodevelopmental disorder with or without brain abnormalities. This work led to a diagnosis in 7 subjects with loss-of-function variants in this gene.The third axis deals with bioinformatics optimization and consists in the implementation of a pipeline using the best tools to genotype microsatellite expansions from short read genome data, with the aim of establishing new diagnoses. We evaluated the 10 most popular tools in the literature and selected 4 of them. We tested them on 23 loci involved in human disease on our cohort of 323 genomes of subjects with neurodevelopmental disorders. This pipeline led to the identification of a pathological microsatellite expansion considered as an incidental finding because the variant was not related to the phenotype of the patient.Our strategy to optimize genomic data analysis in rare diseases is effective: it has reduced diagnostic odyssey, for children in urgent need for etiological diagnosis, and increased the diagnostic yield of exome and short read genome sequencing through the development of new strategies for analysis, re-analysis and large-scale data sharing
Stavrakakis, Yannis. (2024). Populist Discourse–Recasting Populism research. Routledge, 186 pages
No full textThe review of the book Populist Discourse – Recasting Populism Research, written by Yannis Stavrakakis and launched during the Spring of 2024, provides a comprehensive overview of the arguments raised by the author regarding the recent discussion about populism. Among many qualifications, the book facilitates the debate about populism made by Laclau in On Populist Reason. It shows how it can be applied to research on and about populism to help us have a more rigorous and comprehensive approach to political contexts around the Globe. Stavrakakis continue the critical tradition developed by Laclau and Mouffe, deepening our understanding of populism's discursive dimensions in contemporary politics. In my review, I summarize the book, highlight the positive and negative points of Stavrakakis’ approach, and finalise with a guide to help the reader get the best from the book
A scalable framework for stylometric analysis of multi-author documents
No full textThis is an accepted manuscript of a chapter published by Springer in Database Systems for Advanced Applications. DASFAA 2018. Lecture Notes in Computer Science, vol 10827 on 13/05/2018, available online: https://doi.org/10.1007/978-3-319-91452-7_52
The accepted version of the publication may differ from the final published version.Stylometry is a statistical technique used to analyze the variations in the author’s writing styles and is typically applied to authorship attribution problems. In this investigation, we apply stylometry to authorship identification of multi-author documents (AIMD) task. We propose an AIMD technique called Co-Authorship Graph (CAG) which can be used to collaboratively attribute different portions of documents to different authors belonging to the same community. Based on CAG, we propose a novel AIMD solution which (i) significantly outperforms the existing state-of-the-art solution; (ii) can effectively handle a larger number of co-authors; and (iii) is capable of handling the case when some of the listed co-authors have not contributed to the document as a writer. We conducted an extensive experimental study to compare the proposed solution and the best existing AIMD method using real and synthetic datasets. We show that the proposed solution significantly outperforms existing state-of-the-art method
Transmission en activité de dessin et de peinture à l'école maternelle
No full textTransmission in drawing and painting activities in nursery school. - The author observes that child's activity is much more valued and exploited by the teacher for symbolic learning objectives if its instrumental aspect allows a better identification of the cognitive nature of the task required from him, and a better adaptation of the institutional objectives assigned to these activities by reducing its « creative » elaboration.Dans une perspective à la fois descriptive et différentielle, l'analyse est centrée sur l'étude des déterminants et des moyens pédagogiques mis en œuvre par les enseignantes de l'école maternelle dans leurs interactions avec les élèves lors des activités de dessin et de peinture.
La thèse défendue est que le milieu éducatif vise à inhiber la tendance «spontanée» de l'enfant à étendre de plus en plus la tache de couleur et à renforcer la subordination de la graphomotricité aux objectifs d'une représentation iconique inscriptive, consciente et finalisée de l'objet. Ainsi, malgré le « spontanéisme pédagogique » qui caractérise certains courants de la pédagogie moderne (voir Lurçat, RFP n° 71, 39-46), nous constatons que l'activité est d'autant plus valorisée et exploitée par les maîtresses aux fins d'apprentissages symboliques, que son caractère instrumental permet à l'élève de mieux identifier la nature cognitive de la tâche exigée de lui et, en réduisant ses elaborations «créatives», de s'adapter aux objectifs institutionnels assignés à ces activités.Transmisión en actividad de dibujo y de pintura en la escuela maternal. - Nota el autor que la actividad del niño esté tanto más valorizada y explotada por la maestra con el fin de aprendizaje simbólico, cuanto su carácter instrumental le permite mejor identificar lo que toca a la actividad de cognición en el trabajo exigido y, con tal que se reduzca la parte creativa, adaptarse a los objetivos institucionales asignados a estas actividades.Papamichael Yannis. Transmission en activité de dessin et de peinture à l'école maternelle. In: Revue française de pédagogie, volume 74, 1986. pp. 37-45
Towards language-parametric semantic editor services based on declarative type system specifications
No full textEditor services assist programmers to more effectively write and comprehend code. Implementing editor services correctly is not trivial. This paper focuses on the specification of semantic editor services, those that use the semantic model of a program. The specification of refactorings is a common subject of study, but many other semantic editor services have received little attention. We propose a language-parametric approach to the definition of semantic editor services, using a declarative specification of the static semantics of the programming language, and constraint solving. Editor services are specified as constraint problems, and language specifications are used to ensure correctness. We describe our approach for the following semantic editor services: reference resolution, find usages, goto subclasses, code completion, and the extract definition refactoring. We do this in the context of Statix, a constraint language for the specification of type systems. We investigate the specification of editor services in terms of Statix constraints, and the requirements these impose on a suitable solver.Programming Language
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The World Trade Organization and financial stability: the balance between liberalisation and regulation in the GATs
No full textThe WTO General Agreement on Trade in Services and its Annex on Financial Services provide the international legal framework for the regulation of cross-border trade in financial services. This paper analyses some of the main provisions of the GATS and the Annex on Financial Services to determine its impact on domestic financial regulation and whether the GATS framework can achieve its objectives of liberalising international trade in financial services while allowing states to maintain adequate domestic regulatory institutions. The paper argues that the GATS provides a flexible framework for states to negotiate liberalisation commitments while allowing sufficient domestic regulatory authority to achieve financial stability objectives. The extent to which states can depart from their GATS obligations to achieve regulatory objectives has become the source of academic debate and policy interest. Although the WTO has played little or no role in the financial regulation debate, the GATS contains certain disciplines that could potentially have significant implications for limiting regulatory discretion over financial markets. The paper suggests that the Doha Development Agenda should address some of these issues as they relate to the regulation of cross-border trade in financial services. The role of the WTO in this area raises important issues regarding the institutional design of financial regulation and related issues of global financial governance
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