141 research outputs found
Isolation of a somatomedin binding protein from human preterm amniotic fluid : development of a radioimmunoassay
No full textThis thesis study was undertaken in order to investigate
the nature and biological behavior of a somatornedin
binding protein, identified in preterrn amniotic fluid (AF).
Somatomedin (SM) is the generic designation applied to
a family of serum peptide growth factors which are growth
hormone dependent, stimulate incorporation of sulphate
into cartilage, have insulin-like actions on nonskeletal
tissues and increase mitosis in a wide variety of cultured
cells. Thusfar two peptides have been fully characterized:
insulin-like growth factor I (IGF-I), shown to be identical
to sornatomedin-C, and insulin-like growth factor II
(IGF-II). IGF-I and IGF-II have a 62% aminoacid sequence
identity and are 38-48% homologous with the A and B domains
of human pro-insulin
Het gebouw als bewijs
No full textReview of a book edited by Ronald Stenvert and Gabri van Tussenbroe
Etiology and Clinical Presentation of Disorders of Sex Development in Kenyan Children and Adolescents
No full textObjective. )e purpose of this study was to describe baseline data on etiological, clinical, laboratory, and management strategies in
Kenyan children and adolescents with Disorders of Sex Development (DSD). Methods. )is retrospective study included patients
diagnosed with DSD who presented at ages 0–19 years from January 2008 to December 2015 at the Kenyatta National (KNH) and
Gertrude’s Children’s (GCH) Hospitals. After conducting a search in the data registry, a structured data collection sheet was used
for collection of demographic and clinical data. Data analysis involved description of the frequency of occurrence of various
variables, such as etiologic diagnoses and patient characteristics. Results. Data from the records of 71 children and adolescents
were reviewed at KNH (n � 57, 80.3%) and GCH (n � 14, 19.7%). )e mean age at the time of diagnosis was 2.7 years with a median
of 3 months. )irty-nine (54.9%) children had karyotype testing done. )e median age (IQR) of children with reported karyotypes
and those without was 3.3 years (1.3–8.9) and 8.3 years (3.6–12.1), respectively (p � 0.021). Based on karyotype analysis, 19
(48.7%) of karyotyped children had 46,XY DSD and 18 (46.2%) had 46,XX DSD. )ere were two (5.1%) children with sex
chromosome DSD. Among the 71 patients, the most common presumed causes of DSD were ovotesticular DSD (14.1%) and CAH
(11.3%). Majority (95.7%) of the patients presented with symptoms of DSD at birth. )e most common presenting symptom was
ambiguous genitalia, which was present in 66 (93.0%) patients either in isolation or in association with other symptoms. An
ambiguous genitalia was initially observed by the patient’s mother in 51.6% of 62 cases despite the high rate (84.7%) of delivery in
hospital. Seventeen (23.9%) of the cases had a gender reassignment at final diagnosis. A psychologist/psychiatrist or counselor was
involved in the management of 23.9% of the patients. Conclusion. )e commonest presumed cause of DSD was ovotesticular DSD
in contrast to western studies, which found CAH to be more common. Investigation of DSD cases is expensive and needs to be
supported. We would have liked to do molecular genetic analysis outside the country but financial challenges made it impossible.
A network for detailed diagnostics in resource-limited countries would be highly desirable. )ere is a need to train health care
workers and medical students for early diagnosis. Psychological evaluation should be carried out for all patients at diagnosis and
support given for families
The physiological and pathophysiological roles of the GH/IGF-axis in the kidney: Lessons from experimental rodent models
No full textAn interactive E-Learning portal in pediatric endocrinology: Practical experience
No full textBased on educational considerations, the European Society for Paediatric Endocrinology (ESPE) e-learning portal has been developed, providing an interactive learning environment for up-to-date information in pediatric endocrinology. From March 2011 to January 2012, five small-scale pilot studies were completed to assess the usefulness of the structure and content by senior experts, fellows, residents and medical students. Altogether, 8 cases and 4 chapters were studied by a total of 71 individuals: 18 senior experts, 21 fellows, 10 medical students, 9 regional pediatricians and 13 residents, resulting in a total of 127 evaluations. Participants considered the portal content interesting and appreciated the way of learning compared to traditional learning from literature and textbooks. Special attention was paid to assess the personalized feedback given by experts to fellows and residents who completed the portal. Feedback from experts included both medical understanding and communication skills demonstrated by fellows and residents. Users highly appreciated the feedback of the medical experts, who brought perspectives from another clinic. This portal also offers educational opportunities for medical students and regional pediatricians and can be used to develop various CanMEDS competencies, e.g., medical expert, health advocate, and scholar.Education and Student AffairsElectrical Engineering, Mathematics and Computer Scienc
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