197,780 research outputs found
Poet and author Judith Kerman reads her selected works at the Michigan Writers Series
No full textPoet and author Judith Kerman reads selected poems, including the English translation of poems by Cuban poet Dulce Mar\ueda Loynaz, and answers questions from audience. Kerman is introduced by Michigan State University Librarian Jeanne Drewes. Part of the MSU Libraries' Michigan Writers Series. Held in the Main Library
Jeanne Drewes, Assistant Director of the Michigan State University Libraries, talks about "Ediciones Viga," a Cuban artists' cooperative which has produced limited-edition books since 1985
No full textJeanne Drewes, Assistant Director of the Michigan State University Libraries, talks about "Ediciones Vigi\u301a," a Cuban artists' cooperative which has produced limited-edition books since 1985. Drewes explains the hardships faced in Cuba under an American trade embargo and how the Cubans have adapted by making books from all sorts of materials. She answers questions from the audience. Drewes is introduced by MSU Librarian Ruth Ann Jones. Part of the Michigan State University Libraries' Colloquia series. Held at the MSU Main Library
Poet and essayist Ruth Behar reads her selected works at the Michigan Writers Series
No full textPoet and essayist Ruth Behar reads selections from her poetry in both Spanish and English and also reads from her novel in progress. She answers questions from the audience. The event is convened by MSU Librarian Jeanne Drewes. Part of the Michigan State University Libraries' Michigan Writers Series
Qualitätssicherung und Qualitätsentwicklung in der Schulpsychologie.
No full textMüller B, von Hagen A, Jeck S. Qualitätssicherung und Qualitätsentwicklung in der Schulpsychologie. . In: Seifried K, Drewes S, Hasselhorn M, eds. Handbuch Schulpsychologie. Stuttgart: Kohlhammer; 2021: 72-84
MeV-scale seesaw and leptogenesis
No full textWe study the type-I seesaw model with three right-handed neutrinos and Majorana masses below the pion mass. In this mass range, the model parameter space is not only strongly constrained by the requirement to explain the light neutrino masses, but also by experimental searches and cosmological considerations. In the existing literature, three disjoint regions of potentially viable parameter space have been identified. In one of them, all heavy neutrinos decay shortly before big bang nucleosynthesis. In the other two regions, one of the heavy neutrinos either decays between BBN and the CMB decoupling or is quasi-stable. We show that previously unaccounted constraints from photodisintegration of nuclei practically rule out all relevant decays that happen between BBN and the CMB decoupling. Quite remarkably, if all heavy neutrinos decay before BBN, the baryon asymmetry of the universe can be quite generically explained by low-scale leptogenesis, i.e. without further tuning in addition to what is needed to avoid experimental and cosmological constraints. This motivates searches for heavy neutrinos in pion decay experiments
New long-lived particle searches in heavy-ion collisions at the LHC
No full textWe show that heavy-ion collisions at the LHC provide a promising environment to search for signatures with displaced vertices in well-motivated new physics scenarios. Compared to proton collisions, they offer several advantages: (i) the number of parton level interactions per collision is larger, (ii) there is no pileup, (iii) the lower instantaneous luminosity compared to proton collisions allows one to operate the LHC experiments with very loose triggers, and (iv) there are new production mechanisms that are absent in proton collisions We focus on the third point and show that the modification of the triggers alone can increase the number of observable events by orders of magnitude if the long-lived particles are predominantly produced with low transverse momentum. Our results show that collisions of ions lighter than lead are well motivated from the viewpoint of searches for new physics. We illustrate this for the example of heavy neutrinos in the Neutrino Minimal Standard Model
Searching for New Long-Lived Particles in Heavy-Ion Collisions at the LHC
No full textWe show that heavy-ion collisions at the LHC provide a promising environment to search for new long-lived particles in well-motivated new physics scenarios. One advantage lies in the possibility to operate the main detectors with looser triggers, which can increase the number of observable events by orders of magnitude if the long-lived particles are produced with low transverse momentum. In addition, the absence of pileup in heavy-ion collisions can avoid systematic nuisances that will be present in future proton runs, such as the problem of vertex misidentification. Finally, there are new production mechanisms that are absent or inefficient in proton collisions. We show that the looser triggers alone can make searches in heavy-ion data competitive with proton data for the specific example of heavy neutrinos in the neutrino minimal standard model, produced in the decay of B mesons. Our results suggest that collisions of ions lighter than lead, which are currently under discussion in the heavy-ion community, are well motivated from the viewpoint of searches for new physics
Cerebral processing of painful oesophageal stimulation:a study based on independent component analysis of the EEG
No full textUdgivelsesdato: MA
Functional reorganization of brain networks in patients with painful chronic pancreatitis
No full textBACKGROUND: The underlying pain mechanisms of chronic pancreatitis (CP) are incompletely understood, but recent research points to involvement of pathological central nervous system processing involving pain-relevant brain areas. We investigated the organization and connectivity of brain networks involved in nociceptive processing in patients with painful CP.METHODS: Contact heat-evoked potentials (CHEPs) were recorded in 15 patients with CP and in 15 healthy volunteers. The upper abdominal area (sharing spinal innervation with the pancreatic gland) was used as a proxy of 'pancreatic stimulation', while stimulation of a heterologous region remote to the pancreas (right forearm) was used as a control. Subjective pain scores were assessed by visual analogue scale. The brain source organization and connectivity of CHEPs components were analysed.RESULTS: After pancreatic area stimulation, brain source analysis revealed abnormalities in the cingulate/operculo-insular network. A posterior shift of the operculo-insular source (p = 0.004) and an anterior shift of the cingulate source (p < 0.001) were seen in CP patients, along with a decreased strength of the cingulate source (p = 0.01). The operculo-insular shift was positively correlated with the severity of patient clinical pain score (r = 0.61; p = 0.03). No differences in CHEPs characteristics or source localizations were seen following stimulation of the right forearm.CONCLUSIONS: CP patients showed abnormal cerebral processing after stimulation of the upper abdominal area. These changes correlated to the severity of pain the patient was experiencing. Since the upper abdominal area shares spinal innervation with the pancreatic gland, these findings likely reflect maladaptive neuroplastic changes, which are characteristic of CP.</p
Venlafaxine and oxycodone have different effects on spinal and supraspinal activity in man:a somatosensory evoked potential study
No full textIntroductionOpioids and antidepressants that inhibit serotonin and norepinephrine reuptake (SNRI) are recognized as analgesics to treat severe and moderate pain, but for both of them the mechanisms in humans remain unclear. This study aimed to explore how oxycodone (opioid) and venlafaxine (SNRI) modulate spinal and supraspinal sensory processing.MethodsTwenty volunteers were included in this randomized, double blinded, three-way (placebo, oxycodone, venlafaxine), cross-over study. Spinal and full scalp cortical evoked potentials (EPs) to median nerve stimulation were recorded before and after five days of treatment. Assessment of central effects of the three treatments involved: 1) amplitudes and latencies of spinal EPs (spinal level), 2) amplitudes and latencies of the P14 potential (subcortical level), 3) amplitudes and latencies of early and late cortical EPs (cortical level), 4) brain sources underlying early cortical EPs and 5) brain networks underlying the late cortical EPs.ResultsIn the venlafaxine arm, the spinal P11 and the late cortical N60-80 latencies were reduced by 1.8%(95%CI:1.7,1.9%) and 5.7%(95%CI:5.3,6.1%), whereas the early cortical P25 amplitude was decreased by 7.1%(95%CI:6.1,8.7%). Oxycodone increased the sub-cortical P14 (+25%(95%CI:22.2,28.6%)), early cortical N30 (+12.9%(95%CI:12.5,13.2%)) amplitudes and the late cortical N60-80 latency (+2.9%(95%CI:1.9,4.0%)). The brainstem and primary somatosensory cortex source strengths were increased by 66.7%(95%CI:62.5,75.0%) and 28.8%(95%CI:27.5,29.6%) in oxycodone arm, whereas the primary somatosensory cortex strength was decreased in venlafaxine arm by 18.3%(95%CI:12.0,28.1%).ConclusionsOpioids and SNRI drugs exert different central effects. This study contributes to the much needed human models of the mechanisms of drugs with effects on the central nervous system. INTRODUCTION: Opioids and antidepressants that inhibit serotonin and norepinephrine reuptake (SNRI) are recognized as analgesics to treat severe and moderate pain, but for both of them the mechanisms in humans remain unclear. This study aimed to explore how oxycodone (opioid) and venlafaxine (SNRI) modulate spinal and supraspinal sensory processing.METHODS: Twenty volunteers were included in this randomized, double blinded, three-way (placebo, oxycodone, venlafaxine), cross-over study. Spinal and full scalp cortical evoked potentials (EPs) to median nerve stimulation were recorded before and after five days of treatment. Assessment of central effects of the three treatments involved: 1) amplitudes and latencies of spinal EPs (spinal level), 2) amplitudes and latencies of the P14 potential (subcortical level), 3) amplitudes and latencies of early and late cortical EPs (cortical level), 4) brain sources underlying early cortical EPs and 5) brain networks underlying the late cortical EPs.RESULTS: In the venlafaxine arm, the spinal P11 and the late cortical N60-80 latencies were reduced by 1.8%(95%CI:1.7,1.9%) and 5.7%(95%CI:5.3,6.1%), whereas the early cortical P25 amplitude was decreased by 7.1%(95%CI:6.1,8.7%). Oxycodone increased the sub-cortical P14 (+25%(95%CI:22.2,28.6%)), early cortical N30 (+12.9%(95%CI:12.5,13.2%)) amplitudes and the late cortical N60-80 latency (+2.9%(95%CI:1.9,4.0%)). The brainstem and primary somatosensory cortex source strengths were increased by 66.7%(95%CI:62.5,75.0%) and 28.8%(95%CI:27.5,29.6%) in oxycodone arm, whereas the primary somatosensory cortex strength was decreased in venlafaxine arm by 18.3%(95%CI:12.0,28.1%).CONCLUSIONS: Opioids and SNRI drugs exert different central effects. This study contributes to the much needed human models of the mechanisms of drugs with effects on the central nervous system. This article is protected by copyright. All rights reserved.</p
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