126,810 research outputs found
F. N. Draper storefront photograph
No full textTintype photograph of the F. N. Draper storefront, ca. 1870. A sign in the window reads "Boots & Shoes," and hats hang outside the window
Letter from George O. Draper to Amos Alonzo Stagg (April 10, 1941)
No full textThis is a copy of a letter to Amos Alonzo Stagg written by George O. Draper. The letter is dated April 10, 1941. The letter is to notify him that he had been awarded the Edward N. Tarbell Medallion and to give Stagg information on when the award would be presented.For more information on Amos Alonzo Stagg, see: https://springfield.as.atlas-sys.com/agents/people/66
Gregg Dimmitt, David Draper
No full textPhoto of Gregg Dimmitt and David Draper with others on boats in Glen Canyon, during a SOCOTWA river trip on the Colorado River in the 1950s or early 1960
St. Louis Grand March
No full text80.7568.1143 – “St. Louis Grand March”: G. H. Draper: N. Phillips: 1839: Piano
William Draper Lewis (nécrologie)
No full textWilliam Draper Lewis (nécrologie). In: Revue internationale de droit comparé. Vol. 1 N°4, Octobre-décembre 1949. pp. 439-440
William Draper Lewis (nécrologie)
No full textWilliam Draper Lewis (nécrologie). In: Revue internationale de droit comparé. Vol. 1 N°4, Octobre-décembre 1949. pp. 439-440
Depot, Draper, Jones County
No full text3 x 5.5 photograph, one-story building with brackets under the overhanging gable roof and a bay window, old car and wagons outside the building2 Photo Album H2009-101 5644 R.C. Lathrop Coll Box No 3Chicago Milwaukee St. Paul & Pacific Railroad Company Depot at Draper, S Dak. Taken - Sometime in 190 - Division old Black Hills Div, then Old Iowa & Dakota Now I. M. & D. Built May or June 1906 Telg Call = DA MP No 506 Acct N 4106 Looking at the West End, South Side by C. C. Slack & Co
HSD down-regulates basal Draper levels.
No full text(A) Schematic for experimental design and summarized results of (B and C). Flies fed an HSD exhibit reduced Draper signaling despite increased Dilp release. (B) Confocal images of the antennal lobe region of flies fed an ND or an HSD that were immunostained with anti-Draper. (C) Mean fluorescent intensity of Draper measured within a region of interest (white box) that coincides with the location of ensheathing glia in ND and HSD-fed flies. Measurements were obtained from a Z-stack summation projection that spans the entire depth of the antennal lobe. Student t test with Welch’s correction. N = each circle represents an individual fly. (D) Schematic for experimental design and summarized results of (E and F). Flies expressing TrpA1 specifically in their IPCs show reduced Draper signaling similar to flies fed an HSD. (E) Confocal images of Draper levels in the antennal lobe region of control flies and flies expressing TrpA1 in the IPCs that were fed an ND. TrpA1 expression force activates the IPCs to release Dilps. (F) Mean fluorescent intensity of Draper measured within a region of interest (white box) that coincides with the location of ensheathing glia in control and flies with Dilp2-driven TrpA1 expression. Measurements were obtained from a Z-stack summation projection that spans the entire depth of the antennal lobe. Student t test with Welch’s correction. N = each circle represents an individual fly. (G) Schematic for experimental design and summarized results of (H and I). HSD-fed flies expressing EKO specifically in their IPCs show increased Draper signaling compared to control flies. (H) Confocal images of Draper levels in the antennal lobe region of control flies and flies expressing EKO in the IPCs that were fed an HSD. EKO expression attenuates the release of Dilps from the IPCs. (I) Mean fluorescent intensity of Draper measured within a region of interest (white box) that coincides with the location of ensheathing glia in control and flies with Dilp2-driven EKO expression. Measurements were obtained from a Z-stack summation projection that spans the entire depth of the antennal lobe. Student t test with Welch’s correction. N = each circle represents an individual fly. (J) Schematic for experimental design and summarized results of (K and L). HSD-fed flies expressing a constitutively active form of Pi3k specifically in their IPCs show increased ensheathing glia Draper signaling compared to control flies. (K) Confocal images of Draper levels in the antennal lobe region of HSD-fed control flies and flies expressing Pi3k-CAAX in ensheathing glia. (L) Mean fluorescent intensity of Draper measured within a region of interest (white box) that coincides with the location of ensheathing glia. Measurements were obtained from a Z-stack summation projection that spans the entire depth of the antennal lobe. Student’s T test with Welch’s correction. N = each circle represents an individual fly. The data underlying this figure can be found in the supporting information file S3 Data. HSD, high-sugar diet; IPC, insulin-producing cell; Pi3k, phosphoinositide 3-kinase.</p
Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling
No full textDraper/Ced-1/MEGF-10 is an engulfment receptor that promotes clearance of cellular debris in C. elegans, Drosophila and mammals. Draper signals through an evolutionarily conserved Src family kinase cascade to drive cytoskeletal rearrangements and target engulfment through Rac1. Glia also alter gene expression patterns in response to axonal injury but pathways mediating these responses are poorly defined. We show Draper is cell autonomously required for glial activation of transcriptional reporters after axonal injury. We identify TNF receptor associated factor 4 (TRAF4) as a novel Draper binding partner that is required for reporter activation and phagocytosis of axonal debris. TRAF4 and misshapen (MSN) act downstream of Draper to activate c-Jun N-terminal kinase (JNK) signalling in glia, resulting in changes in transcriptional reporters that are dependent on Drosophila AP-1 (dAP-1) and STAT92E. Our data argue injury signals received by Draper at the membrane are important regulators of downstream transcriptional responses in reactive glia.MD/PhDInterdisciplinary Graduate Progra
CCD polarimetry as a probe of regions of recent star-formation
No full textChapter 1 of this thesis details the incorporation of a Charged Coupled Device (CCD) detector system with the Durham Imaging Polarimeter. The details include the physical characteristics of the device and the electronics and software associated with the device control and data storage. The introduction of the CCD detector system haa made necessary the inclusion of a super-achromatic half-wave plate in the polarimeter which has an inherent variability in its optic axis. Chapter 2of this work describes fully how suitable corrections for this effect can be made, and derives "first order" results. The CCD performance is examined in comparison with the detector used previously and hence the veracity of the new results is established. Chapter 3 is a relevant summary of the status of the astronomy of the immediate regions of recent star-formation. Chapter 4 describes multicolour polarimetry of NGC2261/R Mon covering the period 1979 to 1986. The data conclusively proves that the polarisation of R Mon must be due to effects close to R Mon (~ 14 astronomical units). This is evident because of the dynamic timescale of the variations of the polarisation of R Mon and the anomalous band of polarisations seen across the head of the nebula. The interpretation presented is an extension of the Elsasser and Staude (1978) method of polarising objects embedded within the confines of a nearly edge-on disk. Detailed polarisations within the main nebula body provide evidence for this extended interpretation and also for an extensive helical magnetic field which may extend into the disk. Also it is seen that R Mon must still be "shrouded" in material preventing light from directly reflecting in the main nebula body. It is not thought that the variations in the region close to R Mon are due to planetary bodies but to accretion from the disk. The results of this re-interpretation of the polarising mechanism are tentatively applied to other similar objects
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