3 research outputs found
Functional Tax Governance Apparatus and Economic Development
No full textThe proportion of tax earnings to gross domestic product (GDP) in Nigerian economy had been ranked and affirmed the least in the sub-Sahara African and as evolving economy, different reasons attested to this fact, hence, the study is aimed at investigate the inherent lacuna of tax governance apparatus in responses to economic development as broad objective. The study employed field research design, the research instrument that was deployed for collection of data is purposive and structured questionnaire targeted at elicit information from relevant and related stakeholders in tax matters, the research instrument and data collected were subjected to Cronbach alpha test and heteroscedasticity test to affirm the validity/reliability and best linear unbiased estimator of data collected respectively. The result revealed that the responsiveness of economic development to tax assessment, tax policy and tax administration were statistically significant inversely related while tax collection was statistically insignificant related directly with economic development. Thereby study concluded that poor management and administration of tax system in Nigeria responsible for adverse relationship that subsist between the proportion of tax earnings to GDP and resulted decayed and declined physical infrastructures and socio
AUDITING AS A TOOL FOR ACCOUNTABILITY FOR EFFICIENT AND EFFECTIVE SCHOOL ADMINISTRATION
No full textAbstract School administration in Nigeria i
Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans
No full text\ua9 The Author(s) 2024. Background: African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of stroke in these populations is obscure. The Stroke Investigative Research and Educational Network (SIREN) is a multicenter study involving 16 sites in West Africa. We conducted the first-ever genome-wide association study (GWAS) of stroke in indigenous Africans. Methods: Cases were consecutively recruited consenting adults (aged > 18 years) with neuroimaging-confirmed ischemic stroke. Stroke-free controls were ascertained using a locally validated Questionnaire for Verifying Stroke-Free Status. DNA genotyping with the H3Africa array was performed, and following initial quality control, GWAS datasets were imputed into the NIH Trans-Omics for Precision Medicine (TOPMed) release2 from BioData Catalyst. Furthermore, we performed fine-mapping, trans-ethnic meta-analysis, and in silico functional characterization to identify likely causal variants with a functional interpretation. Results: We observed genome-wide significant (P-value < 5.0E−8) SNPs associations near AADACL2 and miRNA (MIR5186) genes in chromosome 3 after adjusting for hypertension, diabetes, dyslipidemia, and cardiac status in the base model as covariates. SNPs near the miRNA (MIR4458) gene in chromosome 5 were also associated with stroke (P-value < 1.0E−6). The putative genes near AADACL2, MIR5186, and MIR4458 genes were protective and novel. SNPs associations with stroke in chromosome 2 were more than 77 kb from the closest gene LINC01854 and SNPs in chromosome 7 were more than 116 kb to the closest gene LINC01446 (P-value < 1.0E−6). In addition, we observed SNPs in genes STXBP5-AS1 (chromosome 6), GALTN9 (chromosome 12), FANCA (chromosome 16), and DLGAP1 (chromosome 18) (P-value < 1.0E−6). Both genomic regions near genes AADACL2 and MIR4458 remained significant following fine mapping. Conclusions: Our findings identify potential roles of regulatory miRNA, intergenic non-coding DNA, and intronic non-coding RNA in the biology of ischemic stroke. These findings reveal new molecular targets that promise to help close the current gaps in accurate African ancestry-based genetic stroke’s risk prediction and development of new targeted interventions to prevent or treat stroke
