6 research outputs found
The Factors Music Making in ''Tamhidat Eyn Ol Ghozat Hamedani'' in a glance
No full textInnovative industries In addition to their aesthetic functions have different effects on words. Endogenous music is one of the Innovative industries effects which can play an important role in beautifying the word and its effect on the audience. The Endogenous music is the music that comes with the use of verbal Innovative industries. Industries that are caused words by similarity or congruence of vowels and consonants more related to each other and created sensible phonetic relationship between them. Categories of frequency, phonology, pun and rhyme are among the Innovative industries that play a major role in creating the endogenous music of poem. In this study, with a descriptive - analytical approach the roll of music maker preparations as an example of a prose poem are discussed.The language of Ein ol-Ghozat in lingual preparations is of preacher and educational that has a addressing mode. He speaks with unadorned language with his audience. However, his words are coupled in some cases with rhythmic language that influences audience despite the intense and sharp in speech and makes his word penetration double in the listener. His Words music is natural music that the listener can feel it with their lives and takes effect of it. One feature of this language is order in the arrangement and companion construction of words that based on music and phonemes music. This music The Music gives importance and Individuation to each word and making preparations prose to a kind of prose poem. Applying some of the thin musical nuances such as the balances (Incrustation and puns) makes the music of book more effective and welcome catching. In other words, coordination of audio and verbal and synchronization that through them prose becomes rhythmic and melodic is one of the beautiful aspects of the mystical prose of Ein ol-Ghozat that arises from his words music and a makes special song, as nature accepts and enjoys its reading. This word music is seen in the garb of the phonetic and pun, repetition, and rhythm being in important parts of speech that close sometimes to prosodic weight. In the prose of Ein ol-Ghozat without feeling prosodic weight by listener, a Wave of song and weight dominates that is a result of phonetic and rhymes, and being Near a number of syllables in each mirror to each other and perhaps in all or part of the mirrors, the number of syllables is the same or close.Replication as a key element of the endogenous music is one of Ein ol-Ghozat 's stylistic characteristic. Replications are seen in three forms in Ein ol-Ghozat languages. 1- Phonetic repetition, this group consists of repeating the pun, rhyme and phoneme layout and etc. 2- Repetition of words or phrases. 3- Word Repetition: The Repetition is one of the most important and beautiful art repetition in preparations that in addition to give the integrated to prose is effective in order to better instill of the concept and content of the message of Ein ol-Ghozat, As repetition of the words "Alas," " O’ Friend," and "O’ Dear" in different phrases has a great influence in stimulation of feeling and induction emotional state to the reader's.Phonetic Repetition: One of the most important aspects of beauty in the mystical prose of Ein ol-Ghozat are voice and phonetic coordination that its peak can be found in a pun and rhyme and Incrustation. The using of rhyme in preparations is not the same. In a place that discussion is education and reasoning generally speaking, is not a poem, but in where that speaking is about stories and anecdotes and analogies or become emotional; usually poems used. One manifestation of this item is short sentences and aphorisms, whether in a place that the word is quote by an old or an important person or whether the author express his own speaks.Apart from these, Ein ol-Ghozat has worked other ways to enrich his words music. The most important of these methods are:•Bringing words that at least their initials are co-voiced. Such as: suffering and testing •Phonemes processing: a kind of endogenous music is repetition and consistency of consonants and vowels that in some cases, with creating the specific endogenous music cause highlighting the phrases and helps to conveying the message and delight of the audience. •Bringing together words that together make a pun is another species of Repetition in the language of Ein ol-Ghozat. This innovative array is One of the best examples of musical creating and growing in vocabulary or sentences. •Bringing together the co-Weight terms is one of the species of phonetic repetition in preparations. Repetition of words or phrases, are of those issues that is used in the mystical prose of Ein ol-Ghozat and is one of the stylistic features and music making elements of his Word. Repeat in Ein ol-Ghozat language, sometimes have artistic and rhetorical aspects that helps to being rhythmic of Ein ol-Ghozat prose and is effective in conveying the meaning and intention of the speaker. Ein ol-Ghozat meanwhile of repetition of thoughts and beliefs of the mystics, repeats words and combinations in the various types, while raising the words musical level and its making it melodic, increase the unilateral obligation role of his own speaking. Sometimes this repetition in the form of word or phrase in the end of sentence comes symmetrically, such that is in the order of the rows is hemistich and If in the terms of syllables number be long, makes a song in the words to
Erratum: Truncating Mutations in UBAP1 Cause Hereditary Spastic Paraplegia (The American Journal of Human Genetics (2019) 104(4) (767–773), (S0002929719300977), (10.1016/j.ajhg.2019.03.001))
No full text(The American Journal of Human Genetics 104, 767–773; April 4, 2019) In the originally published version of this article, authors Ivailo Tournev and Teodora Chamova were mistakenly omitted from the author list. Their names have been added here. The online version of the full article now appears correctly and includes affiliations for the added authors as well as corrections to some of the other affiliations. The authors regret these omissions
Computational analysis of next generation sequencing data : from transcription start sites in bacteria to human non-coding RNAS
No full textThe advent of next generation sequencing (NGS) technologies has revolutionized the field of molecular biology by providing a wealth of sequence data. “Transcriptomics”, which aims to identify and annotate the complete set of RNA molecules transcribed from a genome, is one of the main applications of these high-throughput methods. Special attention has been paid in determining the exact position of the 5’ ends of RNA transcripts, the transcription start sites (TSSs), and subsequently in identifying the regulatory motifs that are ultimately responsible for governing gene expression. Recently, a novel experimental approach termed dRNA-seq has emerged which enables TSS identification in prokaryotic genomes at a genome-wide scale. While the experimental procedure has reached a point of maturity, the computational downstream analysis of dRNA-seq data is still in its infancy. Analysis of dRNA-seq data was previously done manually, a tedious task that is prone to errors and biases. In order to automate this process we developed a computational tool for accurate and systematic analysis of dRNA-seq data to identify the TSSs genome-wide. In particular, we used a Bayesian framework for TSS calling and a Hidden Markov Model to infer the canonical motifs in the promoter regions of TSSs in order to further capture TSSs that show low evidence of expression. In a second contribution, we exploited the power of next generation sequencing to identify and characterize the expression and processing mechanisms of snoRNAs. SnoRNAs are a particular class of non-protein coding RNAs whose main function is post-transcriptional modification of other non-protein coding RNAs. SnoRNAs carry out their function as part of ribonucleoprotein complexes (RNPs). In order to gain insights into these protein-RNA interactions, we used a technique called PAR-CLIP (Photoactivatable-Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation) that allows the identification of protein-RNA contacts at nucleotide resolution. Using PAR-CLIP data, we were able to demonstrate that snoRNAs undergo precise processing and that many loci in the human genome generate snoRNA-like transcripts whose evolutionary conservation and expression are considerably lower than currently catalogued snoRNAs. Finally, we set out to use small RNA-seq data from the ENCODE project to construct a comprehensive catalog of genomic loci that give rise to snoRNAs. In addition we expanded the current catalog of human snoRNAs and studied the plasticity of snoRNA expression across different cell types. Our analysis confirmed prior observations that several snoRNAs show cell type specific expression, mainly in neurons. A more striking observation was that snoRNA expression appears to be strongly dysregulated in cancers which could lead to the identification of novel biomarkers
Control of Fusarium oxysporum f.sp. lycopersici by supernatants with siderophores of Acinetobacter sp.
No full textIlustracionesEl marchitamiento vascular del tomate causado por Fusarium oxysporum f. sp. lycopersici (Fol) es una de las enfermedades más limitantes del cultivo. El uso de fungicidas sistémicos y variedades resistentes a ciertas razas del patógeno no ha sido suficiente para su manejo. En este estudio se aislaron microrganismos productores de sideróforos con potencial biocontrolador sobre la cepa Fol59. Los aislamientos fueron obtenidos de muestras provenientes de la rizósfera y filósfera de árboles de cacao silvestre de cinco zonas de la Amazonía Colombiana. Los quince aislamientos seleccionados por su eficiencia en la síntesis de sideróforos, fueron clasificados dentro de los géneros Acinetobacter sp. (9), Bacillus sp. (2), Delftia sp. (1), Serratia sp. (1), Pseudomonas sp. (1) y Herbaspirillum sp. (1). La aplicación previa a la infección con Fol59 de los sobrenadantes con alto contenido de sideróforos (SodSid), de cinco de los aislamientos de Acinetobacter sp., logró disminuir el AUDPC de la severidad de la enfermedad hasta en un 45 %, siendo el aislamiento CBIO117 el que mayor actividad biocontroladora generó. Finalmente, se observó que los SodSid de Acinetobacter CBIO117 indujeron la expresión de los genes PR1 y ERF1 marcadores de las vías hormonales del Ácido Salicílico y Etileno en la planta respectivamente, pero no del gen (MYC2), factor de transcripción de los genes de defensa dependientes del Ácido Jasmónico. Sin embargo, en las plantas estimuladas con los SodSid CBIO117 e infectadas con Fol59 se indujo la expresión de manera diferencial del gen MYC2, destacando la activación de la defensa dependiente del ácido Jasmónico. Estos resultados demuestran el potencial biocontrolador que tienen los sobrenadantes con sideróforos secretados por aislamientos del género Acinetobacter sp. en la disminución del marchitamiento vascular del tomate, actuando como posibles elicitores de la respuesta de defensa de la planta. (texto tomado de la fuente)The vascular wilt disease of tomato caused by Fusarium oxysporum f. sp. lycopersici (Fol) is one of the most limiting diseases of this crop. The use of systemic fungicides and varieties resistant to certain races of the pathogen have not provided an adequate control. In this study, siderophore-producing microorganisms with biocontrol potential against Fol were isolated from rhizosphere and phyllosphere samples taken from wild cocoa trees in five different locations of the Colombian Amazon. The fifteen isolates selected for being representative of the sampling zones and showing greater production of siderophores were classified within the genera Acinetobacter sp. (9), Bacillus sp. (2), Delftia sp. (1), Serratia sp. (1), Pseudomonas sp. (1) y Herbaspirillum sp. (1). The application before infection with Fol59 of supernatants with a high content of siderophores (SodSid) from five Acinetobacter sp. isolates caused a reduction in the AUDPC of the disease severity of up to 45%, being CBIO117 the isolate which showed greater biocontrol activity. Finally, it was confirmed that SodSid Acinetobacter CBIO117 generated an induction in the expression of PR1 and ERF1 genes, markers of the Salicylic Acid and Ethylene hormonal pathways in the plant, respectively. In contrast the gene (MYC2), a transcription factor of the Jasmonic Acid-dependent defense genes was not expressed. However, in plants stimulated with SodSid CBIO117 and infected with Fol59, MYC2 gene expression was differentially induced, highlighting the activation of the Jasmonic acid-dependent defense that possibly led to counteracting the infection process of the pathogen and reducing the severity of the disease. Our results demonstrate the biotechnological potential of siderophore-producing isolates of the genus Acinetobacter sp. for the control of plant pathogens, eliciting the defensive response in the plant.MaestríaMagíster en Ciencias AgrariasÁrea Curricular en Producción Agraria Sostenibl
The role of epigenetic factors in the pathogenesis of familial X-linked mental retardation (XLMR)
No full textMental retardation (MR) is a handicap with severe implications not only for thosethat suffer from this disability, but also for their families, society and the welfaresystems which support them. A large proportion of these individuals are afflictedwith the X-linked form of the condition. To date a total of 87 genes have beenimplicated in the pathogenesis of X-linked mental retardation (XLMR)
