196,641 research outputs found
Cultura dotta e cultura folclorica nei testi medievali
No full textRaccolta di otto saggi - tutti scritti nella lingua italiana - dedicati al rapporto tra cultura dotta, o ufficiale, collegata alla scrittura, e cultura proveniente dal folclore nelle sue varie forme, leggenda, fiaba, tradizione di un territorio, storia orale
Strain rate effects on mechanical properties in tension of aluminium alloys used in armour applications
No full textThe mechanical properties in tension of two aluminium alloys (AA5059-H131 and AA7039-T651) used in armour applications were determined from tests carried out over a wide range of strain-rates on round specimens. The experimental research was developed in the DynaMat laboratory of the University of Applied Sciences of Southern Switzerland. The target strain rates were set at the following four levels: 10−3, 30, 300 and 1000s−1. The quasi-static tests were performed with a universal electromechanical machine, whereas a hydro-pneumatic machine and a Split Hopkinson Tensile Bar apparatus were used for medium and high strain-rates respectively. The required parameters by the Johnson-Cook constitutive law were also determined
Prove di rimboschimento con semina diretta con l'ausilio di microserre in Alta valle di Susa
No full textA reforestation was realized on the subalpine belt (1800 m asl) by using a direct seed system and biodegradabile plastic protections. This method, developped in Sweden and used with success in the Swiss central Alps, is tested in the western Alps in high summer drought conditions. the reforestation was realized by using a scheme of small groups formed of microcollectives of 15 plastic protections. In every protection have been put 4-6 sedds of Norway spruce. The controls have begun at the end of the first vegetative season
Protocol to analyze circulating small non-coding RNAs by high-throughput RNA sequencing from human plasma samples
No full textThe identification and validation of circulating small non-coding RNA (sncRNA) as biomarkers for disease diagnosis, staging, and response to novel therapies is still a compelling challenge. Pre-analytical variables, such as storage temperature or blood hemolysis, and different analytical approaches affect sncRNA stability, detection, and expression, resulting in discrepancies among studies. Here, we report a systematic standardized protocol to reproducibly analyze circulating sncRNAs, employing high-throughput sncRNA sequencing and qRT-PCR validation, from 200 μL of human plasma samples. For details on the use and execution of this protocol, please refer to Ventriglia et al. (2020), Sebastiani et al. (2017), and Dotta et al. (2018).sponsorship: & nbsp;The work is supported by the Innovative Medicines Initiative 2 (IMI2) Joint Undertaking under grant agreement no.115797-INNODIA and no.945268 INNODIA HARVEST. This joint undertaking receives support from the Union's Horizon 2020 research and innovation programme and EFPIA, JDRF, and the Leona M. and Harry B. Helmsley Charitable Trust. This work is also supported by PON "Ricerca e Innovazione"2014-2020 (ARS01_01270-IDF SHARID - Innovative Devices For SHAping the RIsk of Diabetes) . F.D. was supported by the Italian Ministry of University and Research (2017KAM2R5_003) and Italian Ministry of Health (PROMETEO) . G.S. was supported by the Italian Ministry of University and Research (201793XZ5A_006) and by Italian Ministry of Health Ricerca Finalizzata 2018" (GR-2018-12365577) . The secretarial help of Maddalena Prencipe and Alessandra Mechini was greatly appreciated. (Innovative Medicines Initiative 2 (IMI2) Joint Undertaking|115797, Innovative Medicines Initiative 2 (IMI2) Joint Undertaking|945268, Union's Horizon 2020, EFPIA, JDRF, Leona M. and Harry B. Helmsley Charitable Trust, PON "Ricerca e Innovazione"2014-2020|ARS01_01270, Italian Ministry of University and Research|2017KAM2R5_003, Italian Ministry of University and Research|201793XZ5A_006, Italian Ministry of Health (PROMETEO), Italian Ministry of Health Ricerca Finalizzata 2018|GR-2018-12365577)status: Publishe
Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metformin
No full textAIM:
To compare the tolerability and efficacy of vildagliptin to pioglitazone as add-on therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy over 1-year duration.
METHODS:
This 52-week, multicentre, randomized, active-controlled study compared vildagliptin (50 mg b.i.d., n = 295) and pioglitazone (30 mg daily, n = 281) in patients with inadequate glycaemic control [haemoglobin A1c (HbA(1c)) 7.5-11%] receiving a stable dose of metformin (>or=1500 mg). The primary objective was to demonstrate non-inferiority of vildagliptin at 24 weeks in the change in HbA(1c) from baseline. The objective of the additional 28 weeks of the study was to assess long-term safety, while also assessing mean change from baseline to study end in HbA(1c), fasting plasma glucose and body weight.
RESULTS:
When added to a stable dose of metformin (mean baseline dose approximately 2 g/day), the non-inferiority of HbA(1c) lowering of vildagliptin to pioglitazone over 24 weeks was established at the non-inferiority margin of 0.3% (between-group difference = 0.1%). During the remaining 28 weeks, comparable HbA(1c) decreases were recorded in both groups. Overall adverse event (AE) rates were similar in both groups, as was the occurrence of peripheral oedema. Hypoglycaemia occurred rarely in both groups. Serious AEs occurred more frequently with pioglitazone group. While mean body weight increased significantly in the pioglitazone group (+2.6 kg) from baseline, there was no significant weight gain with vildagliptin (+0.2 kg).
CONCLUSIONS:
When added to metformin, vildagliptin demonstrates favourable safety and tolerability over 1 year. Vildagliptin provided additional HbA(1c) lowering to that achieved with metformin alone and comparable to that achieved with pioglitazone, with only pioglitazone causing weight gain
Identificación y evaluación de factores de resistencia del bovino para su uso en el control de la mosca de los cuernos
No full textEncuadernado con: Accessibility of blood affects the attractiveness of cattle to horn flies / M. Breijo ... [et al.]. -- Med. Vet. Entomol. 10.1111/mve, 12008, 2013. -- A natural cattle immune response against horn fly (Diptera: Muscidae) salivary antigens may regulate parasite blood intake / M. Breijo ... [et al.]. -- J. Ec. Entomol. Advance Access June 21, 2016. -- Evaluation of hematobin as a vaccine candidate to control Haematobia irritans (Diptera: Muscidae) loads in cattle / M. Breijo ... [et al.]. -- J. Ec. Entomol., 11(3), 2017.La mosca de los cuernos, Haematobia irritans es un díptero hematófago de distribución mundial que afecta al ganado bovino generando pérdidas en la ganancia de peso, en la producción lechera y en la calidad de los cueros obtenidos. El control de este parásito se ejerce principalmente en base al uso de insecticidas, lo que ha llevado al desarrollo de resistencia disminuyendo la eficiencia de los sistemas de control. En la búsqueda de nuevas herramientas de control del parásito, en la presente tesis nos abocamos a explorar posibles mecanismos de resistencia innata o adaptativa del bovino a las moscas de los cuernos. En el artículo I, demostramos que la carga de las moscas está relacionada –al menos en parte- con la facilidad de acceso que éstas tienen al alimento. El mayor número de moscas observadas en bovinos oscuros se asoció a un mayor consumo de sangre de las moscas que los parasitaban y a un espesor de epitelio más fino. En el artículo II, se caracterizaron las variaciones estivales de la carga de mosca y el consumo de hemoglobina y se presentaron evidencias de que el bovino podría regular el consumo de sangre y la oferta de moscas en el rodeo a partir de la generación de respuestas inmunes adaptativas dirigidas contra diferentes antígenos salivales. En los artículos III y IV, los ensayos de vacunación a campo con Hematobina (HTB) e Irritina 5 (IT5) (dos antígenos salivales de H. Irritans), mostraron reducciones de las cargas de moscas de 30% y 20% respectivamente, confirmando que la vacunación puede ser una herramienta potencial de control. Finalmente en el artículo IV, se exploró la capacidad de las proteínas recombinantes HTB e IT5 de modular el sistema inmune del hospedador, utilizando macrófagos y linfocitos murinos y se demostró que ambos antígenos son capaces de controlar la producción de óxido nítrico y de interleuquinas. En la presente tesis se demuestra que el bovino cuenta con recursos innatos y adaptativos para la regulación de las cargas parasitarias de las moscas de los cuernos y que la inducción de respuestas inmunes contra antígenos salivales podría ser una herramienta alternativa de control
Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naïve patients with type 2 diabetes mellitus
No full textMechanical behaviour of quenched and self-tempered reinforcing steel in tension under high strain rate
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