121,925 research outputs found
Effects of a trapped vortex cell on thick wing profile
No full textExperimental investigation on the effects originated from a trapped vortex cell on the NACA0024 airfoi
A Bayesian semiparametric vector Multiplicative Error Model
No full textInteractions among multiple time series of positive random variables are crucial in diverse financial applications, from spillover effects to volatility interdependence. A popular model in this setting is the vector Multiplicative Error Model (vMEM) which poses a linear iterative structure on the dynamics of the conditional mean, perturbed by a multiplicative innovation term. A main limitation of vMEM is however its restrictive assumption on the distribution of the random innovation term. A Bayesian semiparametric approach that models the innovation vector as an infinite location-scale mixture of multidimensional kernels with support on the positive orthant is used to address this major shortcoming of vMEM. Computational complications arising from the constraints to the positive orthant are avoided through the formulation of a slice sampler on the parameter-extended unconstrained version of the model. The method is applied to simulated and real data and a flexible specification is obtained that outperforms the classical ones in terms of fitting and predictive power
Recensione de EMANUELA LOCCI (a cura di), Io sono turco!, in «Storia e problemi contemporanei», n. 72, maggio-agosto 2016.
No full textRecensione de EMANUELA LOCCI (a cura di), Io sono turco!, in «Storia e problemi contemporanei», n. 72, maggio-agosto 2016
No full textResponsabilità Medica e Valutazione del danno. Con casi pratici risolti
No full textLa mancata risoluzione del problema non attribuibile all’operato del medico rappresenta una complicanza che deve essere prospettata al paziente con una corretta informazione e quindiaccettata dal paziente sottoscrivendo il Consenso Informato.
Aggiornata alle novità introdotte dalla Riforma Gelli (L. 8 marzo 2017, n. 24), questa nuovissima Opera chiarisce al Professionista legale la metodologia per stabilire se l’inadempimento del medico sia ascrivibile a errore oppure no, in particolare attraverso lo studio della documentazione sanitaria e della cartella clinica.
Vengono approfonditi nella prima parte della trattazione, le tematiche relative al consenso, alle conseguenze derivanti dalla mancata obbligazione informativa, ai doveri del medico e all’assicurazione R.C. sanitaria.
La seconda parte invece, fornisce un’utile raccolta di casi concreti derivati dall’osservazione clinica e medico-legale, che esemplificano le problematiche più ricorrenti (infezioni, embolia polmonare, lesioni iatrogene nell’endoscopia, alcune tematiche della sfera ostetrico-ginecologica e della chirurgia vascolare ecc.), senza tralasciare i risvolti assicurativi e di valutazione del danno
Searching the point of no return in Helicobacter pylori life: necrosis and/or programmed death.
No full textAims: Ultrastructural and molecular studies to support the hypothesis of programmed cell
death in Helicobacter pylori were conducted.
Methods and Results: Evidence of programmed death in H. pylori is provided through
electron microscopic detection and cytochemical labelling of electrondense bodies (EDB),
1 containing packaged DNA in coccoid cells, resembling micronuclei of apoptotic eukaryotic
cells. This morphological evidence is also supported by DNA cleavage in homogeneous
fragments of about 100 base pairs. Programmed cell death was observed in H. pylori cultures at
37 °C, with a maximum of 37á5% of EDB coccoid cells after 7 days. The non-permissive
temperature of 4 °C anticipated this process, with 40% of EDB coccoid forms within 3 days,
and it remained substantially unaffected during the observation time of 14 days.
Conclusion: In these experiments, deprivation of nutrients and a non-permissive temperature
acted as a powerful trigger for programmed cell death.
Significance and Impact of the Study: Helicobacter pylori bacterial populations, under
2 stressing stimuli, can respond with programmed cell suicide as a means of species preservation
Novel strategies to prevent and control biofilm growth on central venous catheters
No full textIn last decades, several strategies based on antiadhesive, antiseptic or antibiotic coating of polymers have been developed to prevent biofilm formation on the outer and inner surfaces of medical devices. However, the so far developed medicated devices are able to delay microbial colonization in spite of definitively solving the problem of biofilm formation and related infections. In fact, these devices mainly suffer from a relatively short persistence of antimicrobial action as consequence of an early and rapid drug release.
In the last years, we focused our research efforts in developing different experimental approaches to prevent microbial colonization of central venous catheters based on the adsorption of antimicrobial agents to synthesized and properly functionalized polyurethanes with the aim to control drug adsorption and release.
The new antibiofilm strategies we are dealing with concern: i) the development of antimicrobial polymers by the use of polyurethanes able to coordinate metal ions (Ag+, Zn2+, etc); ii) the exploiting of the biofilm matrix-degrading enzyme, DispersinB, to enhance the penetration of antibiotics through the biofilm; iii) the set up of a magnetic nanoparticles (MNPs)-based targeting system to fight in situ catheter-related infections.
As the metal ion-containing polymers are concerned, a carboxylated polyetherurethane (PEUA) was treated with silver, copper, zinc, aluminium and iron salts, thus obtaining PEUA-Ag, PEUA-Cu, PEUA-Zn, PEUA-Al and PEUA-Fe. A part from PEUA-Al, all polymers showed significant antimicrobial properties. The most active was PEUA-Ag which resulted to be able to inhibit S. epidermidis biofilm formation up to 16 days.
As the Dispersin B is concerned, we carried out collaborative experiments with Jeff Kaplan group to evaluate the antibiofilm activity of this β-N-acetylglucosaminidase once adsorbed to our polyurethanes, either alone or in combination with antibiotics.
Finally, we are currently developing a strategy to fight in situ biofilm development by the use of antibiotic loaded-MNPs to be intravenously injected in at risk patients and driven to the device implantation areas by the application of an external magnetic field. This approach will allow an in situ, on demand treatment of biofilm infections. Drugs are expected be released only in the close surroundings of the colonized device and when clinically required. If the planned experiments in animals will be successful, patients could be treated either immediately after the device implant or later in presence of signs of infection
Legge 8 marzo 2017, n. 24 Disposizioni in materia di sicurezza delle cure e della persona assistita, nonchè in materia di responsabilità professionale degli esercenti le professioni sanitarie
No full textLa emanazione della Legge 8 marzo 2017, n.24, da molto tetmpo auspicata anche al fine di limitare comportamenti inappropriati quali la medicina difensiva, ha modificato in modo più che significativo la disciplina delle responsabilità penale di tutti gli esercenti le professioni sanitarie e quella della responsabilità civile degli stessi professionisti e dipendenti
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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