3,274 research outputs found
A direct A.C. to A.C. regenerative frequency and voltage converter
No full textIncludes bibliographical references.The reliable variable speed operation of an a. c. machine over a wide speed range is a problem that has received attention for some time. In this thesis a system to permit such operation from a fixed frequency fixed voltage supply is proposed, under the name of the asynchronous modulation converter. This converter is of the cycloconverter family, but is force-commutated and is not synchronised with the supply frequency. The power switching element comprises a power transistor in a diode bridge, coupled to the control circuitry by opto-isolators. The output of the a-mod converter is produced by a "chopper" modulation process and this results in the harmonics present being at frequencies well removed from the fundamental. A feedback system to ensure smooth commutation of the output current from the power switches is described. This feedback system operates by sensing the rate of rise of the inductive voltage surge on the load when a switch is opened to operate a freewheel path switch
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Dominant components of the Thoroughbred metabolome characterised by 1H‐NMR spectroscopy: a metabolite atlas of common biofluids
No full textSummary
Reasons for performing study: Metabonomics is emerging as a powerful tool for disease screening and investigating mammalian metabolism. This study aims to create a metabolic framework by producing a preliminary reference guide for the normal equine metabolic milieu.
Objectives: To metabolically profile plasma, urine and faecal water from healthy racehorses using high resolution 1H-NMR spectroscopy and to provide a list of dominant metabolites present in each biofluid for the benefit of future research in this area.
Study design: This study was performed using seven Thoroughbreds in race training at a single time-point. Urine and faecal samples were collected non-invasively and plasma was obtained from samples taken for routine clinical chemistry purposes.
Methods: Biofluids were analysed using 1H-NMR spectroscopy. Metabolite assignment was achieved via a range of 1D and 2D experiments.
Results: A total of 102 metabolites were assigned across the three biological matrices. A core metabonome of 14 metabolites was ubiquitous across all biofluids. All biological matrices provided a unique window on different aspects of systematic metabolism. Urine was the most populated metabolite matrix with 65 identified metabolites, 39 of which were unique to this biological compartment. A number of these were related to gut microbial host co-metabolism. Faecal samples were the most metabolically variable between animals; acetate was responsible for the majority (28%) of this variation. Short chain fatty acids were the predominant features identified within this biofluid by 1H-NMR spectroscopy.
Conclusions: Metabonomics provides a platform for investigating complex and dynamic interactions between the host and its consortium of gut microbes and has the potential to uncover markers for health and disease in a variety of biofluids. Inherent variation in faecal extracts along with the relative abundance of microbial-mammalian metabolites in urine and invasive nature of plasma sampling, infers that urine is the most appropriate biofluid for the purposes of metabonomic analysis
Zane Grey with Orange A.C. baseball team
No full textThis photograph shows Ohio native Zane Grey with the Orange A.C. Baseball Team, ca. 1896-1904. Prior to becoming a well-known author of western novels, Zane Grey was also a dentist and a semi-professional baseball player, with teams including the Orange Athletic Club and the Newark (New Jersey) Colts
Association of lymph vessel density with occult lymph node metastasis and prognosis in oral squamous cell carcinoma
No full textBackground: The aims of this study were to determine intra (ILVD) and peritumoral (PLVD) lymphatic vessel density (LVD), and to investigate the relationship of LVD with occult metastasis and prognosis. Methods: Eighty-seven oral squamous cell carcinomas, in clinical stages I or II, arising in the tongue or floor of the mouth were stained with podoplanin. Lymphatic vessels were quantified in intra and peritumoral areas by sequential analysis and hot spot evaluation. Associations of the ILVD and PLVD with clinicopathologic parameters were determined by Chi-square or Fisher’s exact test. The 5 and 10-year survival rates were calculated by the Kaplan–Meier and compared using the log-rank test. Results: No significant association was observed between ILVD or PLDV and clinicopathologic variables including occult lymph node metastasis, or clinical follow-up. However, ILVD showed a significant association with regional recurrence (p = 0.040). The perineural invasion was associated with PLVD (p = 0.041). Disease-specific (p = 0.044) and disease-free survivals (p = 0.016) had significant association with PLVD. Conclusions: The intra or peritumoral lymphatic vessel density had no predictive value for occult lymph node metastasis in the early stages of oral cancer arising in the tongue or floor of mouth.Department of Surgery Stomatology Pathology and Radiology Area of Pathology Bauru School of Dentistry University of São Paulo, Alameda Octávio Pinheiro Brisolla, 9-75Oral Oncology Center Aracatuba School of Dentistry São Paulo State University (Unesp)Federal University of São João Del Rei – Midwest Campus Dona LinduDepartment of Head and Neck Surgery Barretos Cancer HospitalDepartment of Head and Neck Surgery and Otorhinolaryngology A.C. Camargo HospitalOral Oncology Center Aracatuba School of Dentistry São Paulo State University (Unesp
Experimental research on spatial distribution of overtopping
No full textThe overtopping empirical formulas calculate the discharge only at the top of the crest of a coastal protection structure. On the other hand, the tolerable overtopping discharges are defined at certain points behind the crest where the total overtopping is reduced. The scope of this thesis is to find an empirical formula to describe the distribution of overtopping at the space behind the crest. This thesis comes as a further investigation on the work conducted by v.Kester [2009] for regular waves. In this research, a physical model was developed on which irregular waves are tested. Because of the duration of the tests and the amount of collected water (significant lose of water during the test), a completely new measuring system was designed. Five influencing parameters (variables) are considered on this research: wave height, wave period/steepness, slope angle, crest freeboard and crest permeability. The entire overtopping process is analysed separately for the total overtopping discharge, the overtopping discharge directly behind the crest and the distribution of overtopping behind the structure. In the analysis of the data collected from the measurements, the impact of the varying parameters is investigated leading to useful conclusions and better understanding of the entire process. Additionally, the experimental findings are analysed and compared to the relative existing methods. Based on the TAW [2002] method which is proposed by the EurOtop Manual [2007], a prediction formula is developed. This formula is a generic version of TAW [2002] formula in which a new reduction factor ?c is introduced in order to describe the decay of the overtopping and thus predict the discharge at any certain distance behind the crest. Other relevant methods are also analysed (Juul Jensen [1984], Steenaard [2002], Besley [1999] and v.Kester [2009]) and conclusions for their applicability are drawn leading to suggested improvements or corrections. Apart from the distribution of overtopping, on this thesis the determination of crest freeboard (which is an ambiguous issue) is also investigated. Finally, suggestions of further research on this topic are discussed. The entire work has been perfomed in close cooperation with van Oord.Hydraulic EngineeringCivil Engineering and Geoscience
Flow over partially liquid filled cavity
No full textExperiments have been carried out to investigate the effect of liquid cavity filling on the behavior of the gas flow over a flat plate cavity. PIV measurements in the gas phase reveal that cavity filling can affect vortex shedding in the cavity mouth. Shear layer vortices can break-up into smaller vortices, thereby losing their periodic interaction with the aft wall and, hence, their sound producing potential. Expected is that this is one of the mechanisms causing sound mitigation in corrugated pipes with liquid addition, observed in literature
On modular lattices generated by chains
No full textDe La Maza, A.C. (reprint author). Instituto de Matematica y Fisica, Universidad de Talca. Casilla 747, Talca, Chile.We describe the free modular lattice generated by two chains and a single point, under the assumption that there are few meets
Quantized current steps due to the a.c. coherent quantum phase-slip effect
No full text| openaire: EC/H2020/862660/EU//QUANTUM E-LEAPS Funding Information: This work was supported by European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 862660/QUANTUM E-LEAPS and Engineering and Physical Sciences Research Council (EPSRC) grant no. EP/T004088/1. Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature Limited.The a.c. Josephson effect predicted in 19621 and observed experimentally in 19632 as quantized ‘voltage steps’ (the Shapiro steps) from photon-assisted tunnelling of Cooper pairs is among the most fundamental phenomena of quantum mechanics and is vital for metrological quantum voltage standards. The physically dual effect, the a.c. coherent quantum phase slip (CQPS), photon-assisted tunnelling of magnetic fluxes through a superconducting nanowire, is envisaged to reveal itself as quantized ‘current steps’3,4. The basic physical significance of the a.c. CQPS is also complemented by practical importance in future current standards, a missing element for closing the quantum metrology triangle5,6. In 2012, the CQPS was demonstrated as superposition of magnetic flux quanta in superconducting nanowires 7. However, the direct flat current steps in superconductors, the only unavailable basic effect of superconductivity to date, was unattainable due to lack of appropriate materials and challenges in circuit engineering. Here we report the direct observation of the dual Shapiro steps in a superconducting nanowire. The sharp steps are clear up to 26 GHz frequency with current values 8.3 nA and limited by the present set-up bandwidth. The current steps were theoretically predicted in small Josephson junctions 30 years ago5. However, unavoidable broadening in Josephson junctions prevents their direct experimental observation8,9. We solve this problem by placing a thin NbN nanowire in an inductive environment.Peer reviewe
Stabiliteit van het achtertalud van een rubble mound golfbreker
No full textCivil Engineering and Geoscience
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