18 research outputs found

    Advancements in Hemodynamic Measurement: Arterial Resonance, Ultrasound, and Machine Learning

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    This thesis covers two separate projects which both use ultrasound to measure a form of blood pressure in very different ways. The first project focuses on the noninvasive measurement of continuous arterial blood pressure via the previously unstudied phenomenon of arterial resonance. While prior research efforts have attempted many methods of noninvasive blood pressure measurement, none has been able to generate continuous, calibration-free measurements based on a first-principles physical model. This work describes the derivation of this resonance-based model, its in vitro validation, and its in vivo testing on 60 subjects. This testing resulted in robust resonance detection and accurate calculation of BP in the large majority of evaluated subjects, representing very promising performance for the first test of a new biomedical technology. The second study changes focus to the measurement of blood pressure in the right atrium of the heart, an important clinical indicator in heart disease patients. Rather than developing a new physical approach, this project used machine learning to model the existing assessments made by cardiologists. Comparison to gold standard invasive catheter measurements showed that model predictions were statistically indistinguishable from cardiologist measurements. Both of these projects represent significant advances in expanding precise blood pressure measurements beyond critical care units and expanding access to a much broader population.</p

    Reconciling mass functions with the star-forming main sequence via mergers

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    We combine star formation along the ‘main sequence’, quiescence and clustering and merging to produce an empirical model for the evolution of individual galaxies. Main-sequence star formation alone would significantly steepen the stellar mass function towards low redshift, in sharp conflict with observation. However, a combination of star formation and merging produces a consistent result for correct choice of the merger rate function. As a result, we are motivated to propose a model in which hierarchical merging is disconnected from environmentally independent star formation. This model can be tested via correlation functions and would produce new constraints on clustering and merging

    Applying technical guidance from the USA for management of impacts of anthropogenic noise on wildlife in other countries: the Canadian context

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    Technical Guidance from the U.S. National Marine Fisheries Service recommends Federal agencies use estimated thresholds for peak sound pressure levels and weighted cumulative sound exposure levels for the onset of permanent (and temporary) hearing threshold shifts in marine mammals. These dual metrics were developed to inform impact assessments within the U.S. legal landscape. Despite its merits, the Technical Guidance contains uncertainties due to a lack of data on marine mammal hearing and auditory response to noise, the underlying assumptions about the representative value of existing data create limitations in the applicability of the Technical Guidance. These limitations warrant consideration before it can be applied effectively in other jurisdictions with different legal standards. Using the Canadian legal framework as a working example, we found that Canadian species are under-represented in the in the dataset used for the Technical Guidance, which also does not address all relevant impact types to meet the precautionary requirements of many Canadian legal standards. Thus, the Technical Guidance alone cannot address all Canadian legal standards and, if the Guidance is incorporated, some adjustments to the criteria within may be needed.The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author

    Virtual-Partition Digital PCR for High-Precision Chromosomal Counting Applications

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    Digital PCR (dPCR) is the gold-standard analytical platform for rapid high-precision quantification of genomic fragments. However, current dPCR assays are generally limited to monitoring 1–2 analytes per sample, thereby limiting the platform’s ability to address some clinical applications that require the simultaneous monitoring of 20–50 analytes per sample. Here, we present virtual-partition dPCR (VPdPCR), a novel analysis methodology enabling the detection of 10 or more target regions per color channel using conventional dPCR hardware and workflow. Furthermore, VPdPCR enables dPCR instruments to overcome upper quantitation limits caused by partitioning error. While traditional dPCR analysis establishes a single threshold to separate negative and positive partitions, VPdPCR establishes multiple thresholds to identify the number of unique targets present in each positive droplet based on fluorescence intensity. Each physical partition is then divided into a series of virtual partitions, and the resulting increase in partition count substantially decreases partitioning error. We present both a theoretical analysis of the advantages of VPdPCR and an experimental demonstration in the form of a 20-plex assay for noninvasive fetal aneuploidy testing. This demonstration assaytested on 432 samples contrived from sheared cell-line DNA at multiple input concentrations and simulated fractions of euploid or trisomy-21 “fetal” DNAis analyzed using both traditional dPCR thresholding and VPdPCR. VPdPCR analysis significantly lowers the variance of the chromosomal ratio across replicates and increases the accuracy of trisomy identification when compared to traditional dPCR, yielding > 98% single-well sensitivity and specificity. VPdPCR has substantial promise for increasing the utility of dPCR in applications requiring ultrahigh-precision quantitation

    Significant Expansion of Real-Time PCR Multiplexing with Traditional Chemistries using Amplitude Modulation

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    The real time polymerase chain reaction (rtPCR) is an essential method for detecting nucleic acids that has a wide range of clinical and research applications. Current multiplexed rtPCR is capable of detecting four to six nucleic acid targets in a single sample. However, advances in clinical medicine are driving the need to measure many more targets at once. We demonstrate a novel method which significantly increases the multiplexing capability of any existing rtPCR instrument without new hardware, software, or chemistry. The technique works by varying the relative TaqMan probe concentrations amongst targets that are measured in a single fluorometric channel. Our fluorescent amplitude modulation method generates a unique rtPCR signature for every combination of targets present in a reaction. We demonstrate this technique by measuring nine different targets across three color channels with TaqMan reporting probes, yielding a detection accuracy of 98.9% across all combinations of targets. In principle this method could be extended to measure 6 or more targets per color channel across any number of color channels without loss in specificity

    Virtual-Partition Digital PCR for High-Precision Chromosomal Counting Applications

    No full text
    Digital PCR (dPCR) is the gold-standard analytical platform for rapid high-precision quantification of genomic fragments. However, current dPCR assays are generally limited to monitoring 1–2 analytes per sample, thereby limiting the platform’s ability to address some clinical applications that require the simultaneous monitoring of 20–50 analytes per sample. Here, we present virtual-partition dPCR (VPdPCR), a novel analysis methodology enabling the detection of 10 or more target regions per color channel using conventional dPCR hardware and workflow. Furthermore, VPdPCR enables dPCR instruments to overcome upper quantitation limits caused by partitioning error. While traditional dPCR analysis establishes a single threshold to separate negative and positive partitions, VPdPCR establishes multiple thresholds to identify the number of unique targets present in each positive droplet based on fluorescence intensity. Each physical partition is then divided into a series of virtual partitions, and the resulting increase in partition count substantially decreases partitioning error. We present both a theoretical analysis of the advantages of VPdPCR and an experimental demonstration in the form of a 20-plex assay for noninvasive fetal aneuploidy testing. This demonstration assaytested on 432 samples contrived from sheared cell-line DNA at multiple input concentrations and simulated fractions of euploid or trisomy-21 “fetal” DNAis analyzed using both traditional dPCR thresholding and VPdPCR. VPdPCR analysis significantly lowers the variance of the chromosomal ratio across replicates and increases the accuracy of trisomy identification when compared to traditional dPCR, yielding > 98% single-well sensitivity and specificity. VPdPCR has substantial promise for increasing the utility of dPCR in applications requiring ultrahigh-precision quantitation

    Pyrene-based lipophilic/biphilic chemosensors for the fluorescence “turn-off” detection of nitroanalytes in aqueous media

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    Two approaches towards "turn off"fluorescence detection of nitroanalytes (dinitro-ortho-cresol (DNOC), 2,4,6-trinitrotoluene (TNT) and Riamilovir (Triazavirin ®) are reported such as by tuning the chemosensors structure or by changing the environment. In both cases the great response was achieved with Stern-Volmer quenching constants (KSV) as high as 2.28-3.14 × 104 M-1 (for structure modification approach) and 4.67 × 105 M-1 (for changing of environment approach). © 2021 Author(s).Russian Foundation for Basic Research, РФФИ, (19-33-90155)This work was supported by the Russian Foundation for Basic Research (Project # 19-33-90155)

    Formalist Classification of Anti-war Stories in Children\'s Literature

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    Anti-war literature is a subset of peace literature. Peace is portrayed in both negative and positive ways. Positive peace is defined on the basis of the concept of moral cosmopolitanism, while negative peace is in contrast to the concept of war. Accordingly, the cosmopolitan stories represent the utopia and the anti-war stories represent the ruined city. The data of this research are picture books with anti-war stories of age groups B and C. This article was written using the analytical-descriptive method and based on the formalist approach to answer how common devices (common formal patterns) are in children's anti-war stories. The result of this research shows that anti-war stories are divided into three categories according to the dominant element of the story based on the part of the triple process of beginning, middle and end of the war: beginning-centered, middle-centered and end-centered. Each of these three categories is further divided into subcategories based on the devices they use. The acceptance of the emerging genre of anti-war literature and the lack of sufficient internal and external research on peace literature for children necessitates research. This article is the first to categorize children's anti-war literature using a formalist approach. Introduction Peace in children's literature is presented in two ways: positive and negative. Positive peace means cosmopolitanism and coexistence while respecting each other's differences. "Negative peace is the absence of violence or war" (Galtung, 1969). In this article, anti-war stories are not stories based on mild and minor violence (such as ridicule or rejection), but the content of anti-war stories is based on the display of extreme violence (such as large-scale wars) with collective and physical injuries. Indeed, such stories represent the beauty of peace by showing the ugliness of war. The novelty of the present study is that it analyzes anti-war stories in children's literature and introduces a new classification. The classification of the forthcoming article not only helps the researchers of comparative literature, but also opens a window to peace literature for the authors of children's literature. Background Although the anti-war literature in the world has received the attention of researchers; But whether in Iran or abroad, there is still a lack of peace research in the field of children's literature. "Journal of Peace Research" abbreviated as JPR is an interdisciplinary monthly magazine that has been publishing research related to peace since 1964 (especially articles related to the causes of violence and conflict solutions). Among the peace research books, we can mention War no more: three centuries of American antiwar and peace writing (2016, Rosenwald). The said book is a collection of articles, stories, songs, memories and speeches that convey the message of anti-war and peace. Chapter 7 of War and American Literature (2021, Rosenwald); With the title "About anti-war literature", this author has also discussed American anti-war literature. In Iran, unlike the literature of holy defense, not much research has been done on anti-war literature. "Exploring Anti- war stories in the holly defense literature" (J′afariyan, 2014) is one of the few researches that have been conducted in this field. The mentioned research deals with the types of characters, anxiety disorders, political-social criticisms and nostalgia in Iranian anti-war stories. Aims, significance, and questions Some people consider anti-war literature to be imported. According to them, this genre is the concern of pacifist writers from countries for whom war recalls the crimes of the World War or the 20-year war in Vietnam and the like. At the same time, Iranian writers associate war with defense against the aggression of the Baathist regime in Iraq and tend to write stable literature. What confirms the necessity of this research is the fact that while writers once praised stability due to an imposed war, some of them now no longer see proxy wars as an inevitable necessity. Therefore, whether right or wrong, anti-war literature has become part of the reality of this country's literature. The research questions are: 1- Corresponding to the three stages of the war process (beginning, middle and end), what are the types of children's anti-war stories in terms of the dominant element? 2- According to the formalist approach, in each of the above-mentioned types of stories, the foregrounding  of the dominant element is based on what devices (formations)? 3- In children's anti-war stories, which devices are consistent with Baudrillard's simulation theory? Research Methodology The research method is analytical-descriptive, and the sample group is selected by the "purposive sampling" method. To complete the sample, the method of "data saturation" was used. Authored and translated books titled "Peace and Friendship" and one hundred and thirty-five picture and illustrated book titles for age groups "B" and "C" were collected from the Iranian publishing market through library research. Stories that had an explicit anti-war theme were separated from them. The sample size resulting from saturation consists of twenty-four works, which are cited below and in the final table of the article. This article's approach to studying children's anti-war stories is the formalist approach. The goal of formalism is to discover the form of the work. The key concepts of the formalist approach are: Form, devices, dominant element, foregrounding, defamiliarization. The war process has three parts "beginning, middle and end". Depending on which part of the threefold process of elemental war predominates, war stories are divided into three categories: initiation-oriented, middle-oriented, and ending-oriented. Each of these threefold categories is classified into sub-categories based on the devices and formalistic arrangements used in the work, and then a detailed tree diagram of each of the above threefold categories is displayed. Conclusion Considering the age conditions and the cognitive level of the children, the visual stories of age group "B" and "C" are very brief, single-core, and single-centered and do not have multiple focus. In other words, these stories explicitly convey only one message (no complex and multiple messages) by using highlighting. Therefore, the dominant element in these stories was clearly emphasized in a convergent manner through devices such as the title of the book, the naming of the characters, the phonetic and semantic forms of the descriptions and the images attached to the text. Based on which dominant element is formed by highlighting which part of the three stages of the war process, anti-war visual stories are divided into three categories: initiation-oriented, middle-oriented, and ending-oriented. In this context, this article, while presenting the devices related to each of the three types of dominant elements mentioned above, shows that despite the claims of some critics who consider the formalist approach to be a mechanical one and lacking a dynamic ability to critique and analyze contemporary literature, formalism, like any other approach, can still be effective in criticism and draw the patterns of similarities and formal differences of stories such as the anti-war stories in children's literature by relying on the dominant element and highlighting devices. References Galtung, Johan. (1969). Violence, Peace, and Peace Research. The Journal of Peace Research. 6(3). Pp: 167- 191. J′afariyan, A. (2014). Exploring Anti- war stories in the holly defense literature. MA degree in the Persian Language and Literature. Shahrekord University: Faculty of Literary and Humanities. [Supervisor: J. Safari & visor: E. Sadeghi] [in Persian]. Rosenwald, Lawrence. (2016). War no more: three centuries of American antiwar and peace writing. New Yurk: Liberary of America. (ISBN: ‎ 978-1598534733). Rosenwald, Lawrence. (2021). "On Anti-war Literature". In War and American Literature. Jennifer. Haytock (Ed.). United Kingdom: Cambridge University Press. Pp: 103- 118. (DOI: https://doi.org/10.1017/9781108654883.010)

    0003

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    Improved Property For Sale 7000New,modern,twotory.nineroomdwelling;1acreofgroundplantedinchoicefruitinfullbearing;largeporchesonthreeBidoftbehouse.Thisisreallya7000 New, modern, two--tory. nine-room dwelling; 1 acre of ground planted in choice fruit in full bearing; large porches on three Bid** of tbe house. This is really a 10.0)0 home. Party U desirous nf selling and will sell for »7000. 4:. 6000New.modern,neathome,atwostorydwellingofeightroomsandbath;locutiononeofthefaftinPaloAlto;sizeoflut75x150moreInndcanbebn?."J>;:?.onsunnysi.U.ii.rtet;fifteenmini!5uctsenthestatica)w..ivenityavenue.226000 New. modern, neat home, a two- story dwelling of eight rooms and bath; locution one of the fa-ft in Palo Alto; size of lut 75x150—more Innd can bebn*?. *" J>;:*?.'—on sunny si.U .ii *.rt*et; fifteen mini !5 **uc t sen the static a ) w..iven-ity avenue. * 22 4500 Two-story dwelling of eight rooms and faith- two-ycuis-old; location, Waverly street; size of lot 70x150. This place ia in excellent shape, and has k on the The Maeedoalaa Cry. A ery from Macedonia Aa*afn la being heard. Hut not the cry that often Has Chrlatlan nation* stirred. For f,- .ii.i.' ih.T.' are rising. "To anna' Te arma!" th«*y cry. And atrrnly they're dt-rlartnx Thryn triumph or they'll die. Lona; ymra have they been trampled !:■ ■:;• iiti the lyrant'a h< ■ 1 I.-■!-- vtani have ih*y been walllnc Their sorrowful appeal, tout; have Christian nations He Tho* -r,-.l t ml . :>i*d ■ id fire. At tim.. In .: bi-im-.i.-ji , They've Isamled for it.-ft-nae Atiil an the cruel tyrnnta Have v.-nta-d hate lnti-n»e. Uut vnln were all their efforts. For they were overthrown. And eruelttra nlreclutia Mude Christian nation* a-rnnn. ' Th.ntch rreat their nt*«l fur auccor. ThiHiah nrycrnt wns their cry. Th.- mljihty t'hrlatliin nations ,Vtt*a nti-w t» niaki- r.-ply. a*or there with vi.nn an.l treutiea And J'iil.nii.leB and |-rei*il. And to nniH-nla tar aueeor The nniliritt. gave alight heed. And bow th- Mil red on tans Around th-lr leaders throng Te ni-ik. i tln--.l atrtiREl-* In hop of righting wrung. By letlli HI they nre rttilnir: *T» nr.tia! To arm"!" they cry. And Bt*mly they're d-clnrlnrr. "We'll ;rl*imph or w.-ll din!" —*TTiee"Vr.- '. Ilute* In Pliiuburg CtuOBj- rle-Trii-. :-.-.ph. GOING TO THE CIRCUS. Interna- Into, est luia heouurotiM-d iu NEW BACON CIPHER. It. I...ul. Dot-tor I lain.* to lln>. Solved *.|iiik.-»f.-jr.- Klddlt*. Dr. W. llutsoii FotU of St. Louis, a well known scholar and scientific In- ri-stlgator, claims to bave discovered a Dew cipher to the writings of William S!:.i;.--|,.-iir.- which proves that Francis Bacon was ln reality tbe author of lhe Shakespeare playa, aays the New ITorfc World. Pr. Ford has worked out and will •ubllsh .1 large number or anagrams frum the text uf the 8bake*i>cnrc plays and rrum the prt'factory odes by Ben JeiiMin and others In the 1823 folio edition, which, he declare*, are the cipher writings of Itacon. In them Is letter- atetl Itneuu'N claim to ibe authorship. They u'lso eoutitln tils urgetit appeal to the decipherer** tu work out all the cipher und let tbe world know tbe truth. The cipher willing discovered by Dr. Ford baa nothing io do with the cipher** Whhh have engdged ttu* attention of Ignatius Donnelly unit other advocat.-- of tin* Bacon fl-fcorj*. Aei-onllin- to his (Ilseoverlc**, made after years of long and patient study. the translations of the anagram* In tin* Sbakespeote plays nut only prove that Bacon wus their author, hut that be chtlmeil to la* the son of Queen I'lina- both and rightful heir to the throne. j They reveal, says Dr. Kurd, many ex I traotSlinary personal and male t*vereU*. : llui perhaps the most remarkable of all ! U tin* liivi-Ktls-titor'H reaillnt; of tin* In- si-riptlon ua the tomb of Sliakesjiearo. wblcb. In* si-j-s. coupled wlib tin* cipher writing in tbe n-xt of Hie plays, shows that tta.-on. witi. tin- assistance of Hen JgHWH. t'Uiumed tbo body nf Simla** ami A RECEPTION GARDEN. ■foirlty Ki.r Wta-orl I'lauua-d tt. Mr- ***>'. n. Trarrra. Something new In the way of entertaining Is what Newport uostesse* are ■till striving for. nnd. although It hud been thought that Ihe Inventive genius of almost everylrody had some time since run the very limit of |rossU*iU-- tles. Mrs. William It. Trnvcnt appear** to have made a discovery that la really novel nnd Interesting, says the New Yurk Herald. Mm. Tracer* con templates ndillnir to the list of Newport's private attractions a Japanese trot-den. where she can give cntcrtainim-iit*. either small or clnlrornte, within an en- •rtronmenf fhrir shall be at least somewhat suggestive of ihe sunny orient. D.-Unite plans hnve not yet ticcn for- mulaicd. but Mra. Travers owns » flt*- et relet) of land which lies between the Ocean drive itftil the souih shore. wlMTv the Japan.--.■ r-nnlcn may be located." 0**oa*eeeeoo*eee»e*o«**ee 640 Emerson Street. Main office: 25U University Ave. Phono Black ill Successors to ENTERPRISE LAUNDRY * Corner s.m. Clara » R. S. BUTTON, Agent « *a * •••••••••••••••-•••••••••a* \ tbls community by the autiuuiiceiuuul' Thames, depositing in Its plac that Kiugling brother** immense elr- j « Outrun*,- tt f (he A«*r* Dlapate. The Acre d -.nut.* boa leetl settletl. Bollvit will in knowledge BrmxU's -ov- en-lgni.v nt I r I great pari .f .\m* i rr lory, whll ■ K- •til will (If y nu Indr-m nlty for inllllr*. v c\|>clldlt m*s nittdi* b> Bolivia nud W ll build a 1 arlmr on lit rlv.-r Mndeini uul a rallw ay from Ma more io Made! I. P. Vandcnroort H. N. Vandcrroort PALO ALTO. TRANSFER CO. ALMA STREET Phone Black 20 I'lano Moving Baggage Transferred Storage F. Luscher Carriage Painter n very fine onk tree .,■. nr-j^-j ,a to Mh|Wt ,n g^ Wnuah lot. House i.- tnoilerii ami eight days, Monday, September 7. is cheap at the Ipber n'» (Sbabcqiearir'ai Ings in the orbdnnl iiiaiutui mil some of Ih meat and beSfw uaiiuscrf]il. together with other indis- .utahli* prutif uf the authorship of tie rent plavs. TLM proof In this <-a-<k-i win Im- f.ninii when 3000 Six-rooms nnd bath; tyro-Story cottage; corner" Kverett avel Waverly street. Tl erty is rented und i tsiniide piece of property. price.; Monday, September U, inclusive, y.', 'Several big excursions will go from i tbis vicinity mid local people will be i\r iVu-il V well represented ut tbo big show. 1 tin. grave Is opened. Dr. Fort's trans- ! Those who go from here shuuld make , Union of the Inscription follows; ,Ml,,rn j every cirort lo arrive in time to see' "I" ashe. goodo friend, for the dead , jtbo magulflceut now free street pa-i *,°*-* ' *-** ■'"■"■ ataeoa dugg: he ro-.-. "•' Imdo. whicb is given in tbe morning See- str: ""*"'- M',v'' ""',"'""":' preceding the opening performance. I «***«■ .■^^;l««ifc WM" lH'm""" and Low Rates Again. Commencing February lolh the | Union F'aciHc will mako thu very low . rate of Wl.tlO from Chicago, 130,00 from : St. Louis and fr2'i.(*0 frntn Omaha to1 Sun t'rutii-lscu, Los Angeles and other points in California. The n.lcs from other eastern cities will bo reduced in i pro [tort ion. If one wishes lo bring their relative* or friends from any place I In lllu Hast, all they have to do Is to make u deposit lor the amouut ol ihe ticket with Mr. I). W. Hitchcock, General Agent of the Union Pacific Railroad Company, No. 1 Montgomery street-, .San Francisco, who will cheer ; fully telegraph lhe order ami attend to all details in a most r.a lis factory man nor* or call upon It. Dnniieherg, Agent' Southern Pucllln Company, Pulo Alio. California. STRONER&BACKUS DAINTERS BALD MEN Or those who are warned hy an increasing shiny spot that they are growing up through their hair, should remember thai Rosemary, Rum and Quinine Hair Tonic will do everything lor them that any hair restorer can. We do uot cluim impossibilities, hut we do cluim that if a -p.irk of life remit inn in the roots, it will be quickened and stimulated. Stops Fallinff Out Hwlps Crowing In Eagle Drug Go. PALO ALTO, CAL. Phono Red 125 1*. O. liox. WU Wall Paper. Hardware. Window Ola** Patau and on., Palatnw. Wbltswhu Tint lag, Plain and lm-.,rni,vr Pn|>t-r Hon|.-int,-. ■MiPIWP>Wa»WW<»a*»*a*M*'*<^ plop- i Three miles of ptirude glorien are tli* ! tltetii. Ilacoii Ml'**'! U. Two-Etoiy. cat© schc 1'' '2750 si-v,.|i-n.„it, le. ,lil«l into tliirty sections, a,„l uacb ___... _rcfwirF ,N rritaIN ,„,. sootioo is a nlio* In ll..lf-« - parade SOCIAL ScrfVICE IN BRITAIN | such as the world lias never seen be- inatliaie ontantrwd In L..nd..u o- 'fore. Iu tbls wonderful display are Mnwi »r Amwrleow *(.ieiet>. j shown 108 beautiful dens, laits ami Word tyaB rc."lv.d receally by tin jcjiges of wild uulmuls, u bunt uf forty -American Institute of t^txlnl Servli i big and little alepbaota, Ilfty hori-es llOUse* [(,.; and over one thousand people. Ono i.V. |. a ]section uf the procession le devoted nun g i . t(( niago|-jOBnt ntJli oQBti* ,loHtB r(,,ire. i llm|IlfjPjf Dipcting consists of ibe nee on tin* sunny siue ot .(i0Utitig Qoraany. Russia' Bngland, i.r. John It. I*nton or N'ottlnglmin. who the street' a largo onk in j France, India, ivrniu, Scotland, ^hofims been the principal ri^resoniative rear of ltd; lot 50x150. This Ignited States, and other countries. 1 of -twin, bettennenl In Bnglnnd for is easily worth taOOoJ1'"8 parfofawiiw that follows, aod thirty .v.*..r-. i*.ioi-^fit >d• ■ ***>'-"'-•_■ ,J which includes the superb spectacular "--"''■•"•"'d production of Jerusalem nnd the !". ""* , . Onisadas, Is tho most magulfloeut .* ''1 "'[J,'.'1,',' display uf ureiiic woiidure ever pro- nufl. tin-lir-n i:nat social settleui.*iit h Two-story dwelling of seven sented by any amusement enterprise j.ou.j.m- rr.ib-ri.-i; itm: *rs. nnd V. II rooms nnd bath' si«j of lot ''** A,,"-r*en* '^ao nieuagerie is III led Blend, brother of **VIHInui T. Stead. to uverllowiug with rare beast* and In lis plan und scope He* organlxtl blrds, lnoludlug lhe only baby elft* 'I"'1 commlliee onnoiuicrti thai tin pbant bred i.n.1 successfully raised in ':'i'1*1" »?«»«"« wl" '"' *?■?'" ['" .U.,ISl..tes..heoulyrhiunceros *»"» captivity and the huit living pair giraffes. lhe circus uiii ult.it exhibit in Ban DROPSY meats! 5 -=*T Tllll- ** A <a 1 Stanford Meat Market ? 2750 n of an Initial meeting In laondnn look- ; Ing 1 the formalluu uf a Hrltish lnsti- ! tuii* of Soeiai Service. The com mil toe ■ganltmilau appointed ut the pn** i the Shafteslmry Instl . ,i. p. Ghidatone.son of tin r: Canon Barnott. who bni Do Voue Ankleo or Limbs SwoIlT Arc Voui* tiycH Puffy? Wo ure the Sole Agent* for tho Only- Thing Known That Cures the Kidney Diseases That Cause Dropsy, vlz.t Fulton Compound*. if. Delicacies Poultry I KRUMBECK & BLAUER * \\ a*** Proprietors « *»c:-c-it:- a •*e.frec.c.•s^<.c•li■-*•1*, tt Ib eew well knows, that dropr la not la l-.-.- .r ■■ ■•■■■■ ,*- t--.ii Ib i. .,-:y alwaja a symptom of ic.ui.'j dHcaae tbat accumpanle* tb* obroelo *tacT> bcrtttufore Iricurable, Ubcco, op totbt-dlBCorrr)' ot tbo Pulton Compound*. 0rup*j was Incurable. It li no*, howener. curable In nearly nine tcutba of all CUM. Uoto lo an I mm* tine n*oo*orj. to wblcb wo rnfar by { Do You Intend to Invest in Realty Here? j If so. do not miss these chances *2,"uo—Iluys a now bouse, t rooms.■WebrtiorSt., hit Si)x ISO. 2 oak trues. *; i.'.ihi—IJuyn a IU room hou-si, llrya'ni *-,*,. cIii-hi lu llaiuil- lon Ava,ffbt50x112. 11,000—High si. block .1, IWxlIS nrar Everett. ill*'. ■•'. %.!■.,. nvenii'*; BOxtSv. -im'ii i;-.i.. a cosy cottage, ruums itm) hath, lot tloxllMJ. No. I location. And du nul forget Lhut H-l-a.-ry. Kaji.rh. olosu in, tol*. SI I.SlMi. mention uf which bus boon made I JOHN F. BYXBEE a* Palo Jill:,. California & ll. This U „l,,1 ir, ni,-,. litv .-,11x11-2 f,..l home |i!,i slirtilila-ry; Ironl; l„rs, l,,r:,l,',t: Ittll liiintllr. , ff»ti, statin.,: (.',...1 ll< bt.rlto.al. I'„,|..-ily i- .-, tv„rli, *.'H«",. ii,,. r, •|,t U niniproved Property For Sale 1100 Lot S0O90— loffl-lootalle ,li,l l.M-nli,,!,. ; -pi.- Jose on .Monday. September 21, lor a • meday Bland. - V. M. C. A. BULLETIN. Al'iilinitiouf i.n-.on HI.- ul (he quarters .-I the V. .M. C. A. Employ* meut IJiirenii, Room 60, (jnsiiraugloi for -.indent*, lu III! Uu- following positions' . Wort; for room and board. Waiting on (able—geueral bouse* work plain ooolilog (private family! ■•ai-ileuiug -- miscallaiieous —- lomn for care of lawu room foi janitor work- -to i\o plain cooking. Work for cash. lioiinttork gardening mir-i-ellau- Tbe 'enmnSwrK an* of the opinion thai tie* time bus u.iW come for <-o;utilnln-a .Miun.-i id itir..-iiiatloii and sugves-.Ion relating in social nmellaratlMi. which tut- scattered iu mnnj minds and In ninny organization* llirnnchoiti Creal Itrltaln. Tin* flirlsthin religion, wl'li •ui: di-uoi:ilua!iuUal distlin supply th- basis ot. pnipo It h:ts itl*m l**i-ti 'iht-iilaxl-'that In vlet of 'In- w it- ly differing condition-, lu til I i im ptiMK of ih- Hrltl-h Isles th tl"*..- ui.liiu'.-'shall eonslBl of Neotli**! Irish, Welsh ami English sections. CANE FOR JUSTICE HARLAN Judee E. I -e. I \\ iii-ox of tin- district ,-... who sailed is, bTvaasi a... s*».s.|? J lli-r pht-ilulao bud tln.illy lu tup bvr every le day*. Sin-Kit. Upptxl neatly ft.rtytlmaat.Ld Sr.-w norno fnim dny to day. Tne phyalnnn i.allr told b<r liiikbaDd tba*. abo bad lirml.fa Ii,-nr.u ol tbi- lildiu-y-., tbat It was In an a.l ..,-,.!.:..: * at*asd 0*yjul aaMleal aid. Iltjrbeart alMii;:iv.;h.-r ;!.n ui-ual trouble and '■ the *a* lu ai.i-ii n .,-rli,uic.i.itltti>ti thcn-tatlv, , were-njut fur Tliey put bur t.o IX.lion'* Cetn- pound It i-.i.,-. i oa tbo alomacb. tba or. i Itiliig iKat hB'l ir.inn *o fora Willi). ITcre art-iiTiil' wirtui tlie di.i|n}' il.'illtii-d a llt:ln at.d tin- 1111- proremiut *hik ttmn graiiral till her rci-nvt ty wa* tMmptoia Tlii* i-»*t, waa examined in, l>> r. in. ■•-t.:..-r.t-, .,f Ibo fv.ii Krantiaco S:,.i Bin! thu OiTrlninl Muntlitr, anil Iti. p.-t;uiM'i I si of tb.* cii*.' anil ttiu rccov.ry *nr fu.ly Btichtid In itiotr cailutiuiB r*. Ttiullia*<**irl*t<il of 4i?f, T«*-nrT-*****ntt .-!. S\.!, i- .- . ! , ,,, *-, . , .,:■:■ -'.■■ ... !. ..: : y. an Itiu n-.tilt nf cbruiili- til.lt>*-> dlrenwl. irn iliau i,evL*niJ-0*n i*,unil» U-jond b*l ,1 B.tu:!il, ami bud lo Ih! n <ifrd la *hi.'«li. ■on i-i.isn tod.-a-.ti's deer Bla**SBSta abr bad itiy.li-lana. Sbe wa* jint nn thr Put toe nut.Jsi Thn*.. we.-ltB ►t.uv.ni luipreienirnl :. .ti tii'.tjtti* abo waa welt, and pStmllS ni Sara ilropay don't trntporlie. Then* I* IM total k-j.tttn it.jt irlli cure the ctirvtili . dls ..-.- Ihal I. Iieliitifl ll and that it B*s i..itui«.nnd. Tlio Beaal Compoui fa and Kldt,-y pi—n*,-.. *|; for lilat Ramblers This wheel is mnnii* fatftnred out of the ; best materials mul will out-wenr any wheel nn themnrket today. SHREWSBURY & SMITH HARRY CORBALEY Sole .-Vgent Electrical and Mechanical Engineer 210 University Avenue «*«,*«-*, Wlri,,, (,r,..n,„. Trie.-t,..,, PALO ALTO Phono Black tqLj*8!k\^^ United Cas and Electric Co. LIGHT. HEAT AND POWER .-•. ,\.Ni|i|icrt -Kc.two.Ml City, l'i-lrlct MannKer (J allioiiila. THE PLAZA Artesian Well Drilling t^e-stGUrG\Mt Pa'o Alto an«! San Maleo AND ROOMING HOUIC w.^*^... EUTE MAR«ET , Julin J. Fulli - Pone r* New o aula Bvt>u.a for i-■■- 'III fi. \I t'l i*d ! JK'ill— Un lOOxloQun Mi (Idle field Uoad. dose t.. t'niv.r.-ity uveniie. This It>t i? at tUHXi. *1,(KKI- aventii- near Cowju-r street' tine (ovation for future in- *dlscellaBcous. Clerking, canvassing, student gym* nuet for V. al. C. -V ui salary- commercial traveling for graduate heiipjiKisltig. Kiiipt.iymeut Wsnt*;*d: '] Kliiilei.tf- are iiviiilable for work by •f***y j tbe hour, piano playing, bookkeeping and cullectiug. The Bureau otOoa hours are from J Tin- crtne 1:20* Saturday, 8:15 to - to his liotui- iu Sou Hi led vvlili him a uitliiu Justice Harlan of tbe Ins supreme court, says Uu rros]tondent of tin- Wash It in made nil < of I'orlo Itien Is inscribed. tli.' tlair." prii-Iatlui ■Th -diver, folio' 1,400—Lot lOQaloO -.In-.-t ■ !■■- tl avenue; line hn home. :!.", l.iwi^.ri niver.-ity in for n i GRANTED DEGREES. ed ilcgn have t , lo fourteen nplaled their ie university. IIIIHtlttllll This Is a recognlHon ot ap of Justice Harlan'-, dedsioi, with tbe sentiment (|Uulcd win in- presented to Jtmihv Harlan hy Judge Wilcox lu tiehnlf of lioh-iiati-. Ftplaun Colon and olhe* frii-mls of Jltallce llitrlan in Pence. Srarch Pot ., Nrw (iralra It..ale. A ltrltit.li expedition lias been sent to rxplore iiuiicou bay for the purpose of letorthlnlng wbeiner a now craln rout*1 - i I* practicable. The plan is to «h. ■ - grain from ihe western inrtlon r c; -. a.la. in i»- stored in elevator*1 on Um* . son hay and **hli»jn-d hy **-atcr dntina a. tin- brief suiuiucr seasou lu which im . ; gallon Is opcn„ Walter C. .Muloy uf Sau Jose: in law. Carl ITedcrlck Dittmar of Charles Jossclyn. whose "TrueNa- Kedding, Kegiuald Uoodwin Fernald .poleou" received futorable criticism ..r .Siiiitt. Ilitrhttiii. AIh* Ferry llarrr** lur-t year, luo- in prt-M. for early publi- ol San Jose, Hall Carlo-. Ross of IM- cation by tbe I'aul Elder Company, n . Andrew Curl Tbamnsoa of colleclion of iulere*.tiug and lin-lruc- oifl: in pliy»iuIogy, ilury Ash ti\e select ions from fHinuiiB nulbur», mun Uodgoof Snu Diego: In Geology, enttUad '-.My Favorite Hook Shelf." Irving Anderson of Mallace, Idahu. Unlike the usual i|iiotatiuu Inaik. lhis - Kail tl. Kucpper of Lot. Angel. ■ , I.i volume include* }ta**ugeii of i.'...li.l.l, in* in ! *"*",1 Augustus Smith Jr. of Stanford. . length, so chosen and hminted in < pv-tr j The degree of master uf arts wan many cases as to epitomize tbe uies- ] a mo. led Miss Dorothea Elizabeth Xath sages of tbe volumiuous originals. < of Davenport, lotva, a student of (Jor-, Tbe work will make a handsome oc- i i muu, aud Miss Etlie Lemouds of I'alo I taro, luteresllugly printed and rubri- - J j Alto, a studeut lu tbe English depart, cated. Tbe binding is from a design | * PalO AltO, Cal. ment. I by Gordon Boss. , ... The followjig luck.- ,,.„.„„, aa,,, A word to anv tine (ksirinii tu BrMfJ{ bachelor of arts: purcll.isp Pain Alio prppCTty. I he- ■'' English. Jessie Eugenia MoCI Hcve that all uoimproi ed property S" "f S* *"J; J'1. hlf,u,ry:,"""' r ii. Spencer Feiflvnl uf Corning; in t now nik-u-ij fiir sale ill Palo Altu onii shoultl he Mild al least une-lliinl iti::iif t In no place in California can tin: same amnuiii uf inunev he "' ■ invested ami ei|iiallv as i;utid re- !" turns he obtained as in Palo Aim mtu real estate. J. J. Morris EAGLE DRUG CO. oooooeeeooooooecoeoooooeee a o ■ If you need unv of the above wrltebrcall * I B. F. HALL : • Real Estate and % House Broker % 128 University Ate., Palo Altu • « I ■ ! FOR RENT i • • • ..SnlendJd 10-room house • a verv cent nil. t*-OR**n)otoly • S lumiplied. ^WOa month." 2 • One very nice 4-rooiu o • unfurnished cottage, splt-n- %{ • dill location, 1-esl frontage, *> a fls.tH). * a o i t ::-rooni house tjS.OO % % 'i-rooin house fT.-'iO j c 2-rotnii house (0.00 % FOR SALE a l-ro<mi house, hit .Mix 100 J best frontacc. clow in. -foOO a ■ Lvrootn cottage. lot 50x % 125, with shrubbery and • I 20 lien ring fruit tree.*.. Col- » t lepeTi*mice'*7tKl. J • r* _ t -e * a b room nou>e, Terrace, • ; ii,aoo. ; •a Watch for aniiuunecment • t in Block 36*. 2 • • • a • ••aaaAftft,t>*t>0t>maA»aa* SI to Loan on Real Estate Security J. T. DUNN 621 Emerson St. MKA'i'S .11 I'nra Meat I'radit.t. ■ Tho 3 Little Tailors 255 ttnl.rrMt. ... .2..r,IlSuitsfor-.'2..r,Il Suits for ir>.l)tl 25.(10 Suits for 10.110 .-iiiiin Suiis for -Minn I'rcssiuj; Suits, SOc Praning [\-iuts, 15c I.atlics' Skirts. - 50c lakia .lane Garnirals jBTsdriii werry & son sure* TRAN8FCR **o EXPRESS BpwtPtlr Storage of Furniture ******* order*'at l.at'tlrt , *tort or at real. ' lie*..', I.I.- lli-.ll Mini Needed in Every Home X@N THE NEW LnSJaoMJ AND ENLARGED \^™«/ EDITION OF .WEBSTER'S iNTERNATIONiaL Dictionary New I'Litt-a Throurhout 25,000 New Words Phraaaa and Daf inliloti* l'i.■■■.-,:.■■! mi'ilrr lhe direct »tt|n.'r- vlnion of W. T. HARRIS, Ph.D., LL.D.. United States Cou.i.ii*.-ii,u,r of K,li. cetlui^^ialvilbrn large Cfin«of mm iicteut si'ii-iuii-i- and ii I i lorn. Rich nindlnia 2364 Quarta fai.a 3000 llluatratlona OfTho Internal ionol tmo^rtlit ■reding tht i Eulurord KdUioit of th, "I'nnbriilyrd.' "Ml' I'M 1S90, ■' Tho JS'tif International trrta Vamiri/ in Oelobr, 1900. Pel tho latest and *W. Wenlao|.iilillah W.L*l-ra Callanlata Dlcllanarr -illitili-*Mrj..f *-,-i, it., li \V,, i ,!,*,. | |-i,,.,^-. I'ii**t-cl**-i lii giialllr.a*-at*ood<-«a**l lii alao.* t-ltoen i*n.t-*. ete. of Ix-th ka Mill on ai.i.ll, alum. S £* G OCMERRIAMCO./vtmn Publishers, oprlncfleki, Mau
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