100 research outputs found
Deletion of macro domain containing 2(MACRO D2) associated with transient hydrops fetalis
No full textCilingir, I. Uzun (Trakya Author)
Sayin, Niyazi Cenk (Trakya Author)
Gurkan, H.(Trakya Author)
Ciftdemir, N. A. (Trakya Author)
Atli, E. (Trakya Author)
Inan, C. (Trakya Author)
Erzincan, S. (Trakya Author)
Sutcu, H. (Trakya Author)
Vatansever, U. (Trakya Author)
Varol, Fusun (Trakya Author)Macro Domain Containing 2 (MACRO D2) gene is a gene from macro family which is highly expressed in the ventriculer zone of the brain during embryonic development. Association between Autism spectrum disorders and MACRO D2 gene polymorphisms has been reported before [1] . Deletion in MACRO D2 gene has also been associated with Kabuki Syndrome which is a well described congential anomaly syndrome [2]
Do N-Terminal Pro-C-Type Natriuretic Peptide Levels Relate to Severity of Preeclampsia?
No full textAim. To compare the plasma N-terminal pro-C-type natriuretic peptide concentrations of normotensive pregnant women, patients with mild preeclampsia, and patients with severe preeclampsia. Methods. We collected venous blood samples from 25 normotensive pregnant women, 15 patients with mild preeclampsia, and 15 patients with severe preeclampsia. The women were at 30th to 40th weeks of gestation and in an age range of 20 to 35. The N-terminal pro-C-type natriuretic peptide levels were measured by ELISA. Statistical comparisons were made by one-way analysis of variance, Kruskal-Wallis, and Mann-Whitney U tests. Results. The median (interquartile range-IQR) values of the N-terminal pro-C-type natriuretic peptide were 6.48 (3.33) pmol/L in the normotensive women group, 7.37 (3.43) pmol/L in patients with mild preeclampsia, and 11.52 (6.13) pmol/L in patients with severe preeclampsia. The N-terminal pro-C-type natriuretic peptide was significantly elevated in the severe preeclampsia study group (P<0.001), whereas there was no significant difference between those with mild preeclampsia and the normotensive groups (P>0.05). Conclusion. Our data indicate that the plasma concentration of the N-terminal pro-C-type natriuretic peptide is significantly increased in patients with severe preeclampsia, but not in patients with mild preeclampsia. The severity of preeclampsia may be related to the circulating levels of the N-terminal pro-C-type natriuretic peptide concentrations
Comparison of Ceftazidime-Avibactam Susceptibility Testing Methods Against Oxa-48 Carrying <i>klebsiella </I>blood Stream Isolates
No full textVatansever, Cansel/0000-0003-3703-1882; Kapmaz, Mahir/0000-0002-4115-3914; Aydın, Mehtap/0000-0003-4044-9366; Ergonul, Onder/0000-0003-1935-9235; Keske, Şiran/0000-0003-3823-4454; can, fusun/0000-0001-9387-2526; Azap, Alpay/0000-0001-5035-055X; DOGAN, OZLEM/0000-0002-6505-4582; Tukenmez Tigen, Elif/0000-0003-2027-4116; Forde, Brian/0000-0002-2264-4785; Cinar, Gule/0000-0002-7635-8848; balkan, ilker inanc/0000-0002-8977-5931; Harris, Patrick/0000-0002-2895-0345; Bauer, Michelle/0000-0003-2259-5044Ceftazidime-avibactam exhibits good in vitro activity against carbapenem resistant Klebsiella carrying OXA-48-like enzymes. We tested two hundred unique carbapenem resistant Klebsiella blood stream isolates (71% with single OXA-48-like carbapenemases, including OXA-48, n = 62; OXA-232, n = 57; OXA-244, n = 17; OXA-181, n = 5) that were collected as part of a multicentre study against ceftazidime-avibactam using Etest (bioMerieux, Marcyl'Etoile, France), 10/4 mg disc (Thermo Fisher) and Sensititre Gram Negative EURGNCOL Plates (Lyophilized panels, Sensititre, Thermo Fisher) with the aim of comparing the performances of the Etest and disc to that of Sensititre. Ceftazidime-avibactam MIC50/90 was 2/> 16 mg/L for the entire collection and was 2/4 mg/L for single OXA-48-like producers. Categorical and essential agreements between the Etest and Sensititre were 100% and 97%, respectively. Categorical agreement between the disc and Sensititre was 100%. Etest and 10/4 mg discs are suitable alternatives to Sensititre for ceftazidime-avibactam sensitivity testing for OXA-48-like producers. (C) 2022 Elsevier Inc. All rights reserved.Pfizer Global Medical Grants [56644459]; Advance Queensland Industry Research Fellowship from the Queens-land GovernmentFunding This work was supported by Pfizer Global Medical Grants (grant number 56644459) . Dr Brian Forde?s research is supported by Advance Queensland Industry Research Fellowship from the Queens-land Government
High Prevalence of Arma-16s Rrna Methyltransferase Among Aminoglycoside-Resistant <i>klebsiella Pneumoniae</I> Bloodstream Isolates
No full textTukenmez Tigen, Elif/0000-0003-2027-4116; DOGAN, OZLEM/0000-0002-6505-4582; Azap, Alpay/0000-0001-5035-055X; Keske, Şiran/0000-0003-3823-4454; Vatansever, Cansel/0000-0003-3703-1882; Kapmaz, Mahir/0000-0002-4115-3914; Harris, Patrick/0000-0002-2895-0345; Isler, Burcu/0000-0003-1362-2434; Ergonul, Onder/0000-0003-1935-9235Introduction. Aminoglycosides are used for the treatment of carbapenemase-producing Klebsiella pneumoniae (CPK) infections. 16S rRNA methyltransferases (RMTs) confer resistance to all aminoglycosides and are often cocarried with NDM. Hypothesis/Gap Statement. There is a dart of studies looking at the aminoglycoside resistance mechanisms for invasive CPK isolates, particularly in OXA-48 endemic settings. Aim. We aimed to determine the prevalence of RMTs and their association with beta lactamases and MLSTs amongst aminoglycoside-resistant CPK bloodstream isolates in an OXA-48 endemic setting. Methodology. CPK isolates (n=181), collected as part of a multicentre cohort study, were tested for amikacin, gentamicin and tobramycin susceptibility using custom-made sensititre plates (GN2XF, Thermo Fisher Scientific). All isolates were previously subjected to whole-genome sequencing. Carbapenemases, RMTs, MLSTs and plasmid incompatibility groups were detected on the assembled genomes. Results. Of the 181 isolates, 109(60 %) were resistant to all three aminoglycosides, and 96 of 109(88 %) aminoglycoside-resistant isolates carried an RMT (85 ArmA, 10 RmtC, 4 RmtF1; three isolates cocarried ArmA and RmtC). Main clonal types associated with ArmA were ST2096 (49/85, 58%) and ST14 (24/85, 28 %), harbouring mainly OXA-232 and OXA-48 +NDM, respectively. RmtC was cocarried with NDM (5/10) on ST395, and NDM +OXA-48 or NDM +KPC (4/10) on ST14, ST15 and ST16. All RMT producers also carried CTX-M- 15, and the majority cocarried SHV-106, TEM-150 and multiple other antibiotic resistance genes. The majority of the isolates harboured a combination of IncFIB, IncH and IncL/M type plasmids. Non-NDM producing isolates remained susceptible to ceftazidime-avibactam. Conclusion. Aminoglycoside resistance amongst CPK bloodstream isolates is extremely common and mainly driven by clonal spread of ArmA carried on ST2096 and ST14, associated with OXA-232 and OXA48 +NDM carriage, respectively.Pfizer Global Medical Grants [56644459]; Advance Queensland Industry Research Fellowship from the Queensland GovernmentThis work was supported by Pfizer Global Medical Grants (grant number 56644459). Dr Brian Forde's research is supported by Advance Queensland Industry Research Fellowship from the Queensland Government
Analysis of some ecological features and heavy metal accumulation status of crithmum maritimum l. from kandıra coast, Kocaeli-Turkey
No full text
Properties of na‐montmorillonite and cellulose nanocrystal reinforced poly(butyl acrylate‐co‐methyl methacrylate) nanocomposites
No full textPoly(butyl acrylate-co-methyl methacrylate) (BA-co-MMA) nanocomposite latexes were synthesized in the presence of sodium montmorillonite (Na-MMT) and cellulose nanocrystal (CNC) as fillers. Nanocomposite preparation with 3 wt% Na-MMT based upon the total monomer amount was conducted by semi-batch emulsion polymerization. Furthermore, direct blending of neat copolymer latex with Na-MMT was performed for comparison. CNC/BA-co-MMA nanocomposites were obtained via blending process with varying CNC content (1, 2, and 3 wt %). Good dispersion of both Na-MMT and CNC within the copolymer matrix was achieved as demonstrated by X-ray diffraction and transmission electron microscope. Particle size of the nanocomposite latexes was around 120 nm. Thermal, mechanical, and barrier properties of the copolymer showed great improvement with the addition of both Na-MMT and CNC. CNC nanocomposites displayed enhanced properties with increasing CNC level. Tensile strength of copolymer latex with 3 wt% CNC reached 262.5% of the pristine latex, while tensile strength of Na-MMT nanocomposite at the same content was 187.5% of the pristine latex. (C) 2015 Society of Plastics Engineer
Synthesis of poly(butyl acrylate‐co‐methyl methacrylate)/montmorillonite waterborne nanocomposite via semibatch emulsion polymerization
No full textPoly(butyl acrylate-co-methyl methacrylate)-montmorillonite (MMT) waterborne nanocomposites were successfully synthesized by semibatch emulsion polymerization. The syntheses of the nanocomposites were performed in presence of sodium montmorillonite (Na-MMT) and organically modified montmorillonite (O-MMT). O-MMT was used directly after the modification of Na-MMT with dimethyl dioctadecyl ammonium chloride. Both Na-MMT and O-MMT were sonified to obtain nanocomposites with 47 wt % solids and 3 wt % Na-MMT or O-MMT content. Average particle sizes of Na-MMT nanocomposites were measured as 110-150 nm while O-MMT nanocomposites were measured as 200-350 nm. Both Na-MMT and O-MMT increased thermal, mechanical, and barrier properties (water vapor and oxygen permeability) of the pristine copolymer explicitly. X-ray diffraction and transmission electron microscope studies show that exfoliated morphology was obtained. The gloss values of O-MMT nanocomposites were found to be higher than that of the pristine copolymer. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42373
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