151 research outputs found
Designing a bidirectional, adaptive neural interface incorporating machine learning capabilities and memristor-enhanced hardware
No full textBuilding bidirectional biointerfaces is one of the key challenges of modern engineering and medicine, with dramatic potential impact on bioprosthetics. Two of the major challenges of biointerface design concern signal stability and power efficiency. The former entails: a) ensuring that biosignal inputs corresponding to the same ground truth (e.g. patient “intentions”) are recorded and interpreted consistently and b) maintaining the mapping from biointerface stimulation outputs to behavioral outputs (e.g. muscle movements). In this work we demonstrate how machine learning techniques, state-of-art nanoelectronics and microfluidics can combine forces to build and test low-power, adaptable biointerfaces that address both key challenges. Specifically, we demonstrate that: 1) we can emulate the input/output transfer characteristics of a structure biological neural network (BNN) with an artificial one (ANN), 2) it is possible to translate the resulting, “ideally trained” ANN into a hardware network using RRAM devices as synapses without significant loss of accuracy, despite concerns in the community about RRAM device reliability and 3) using a very simple mechanism of shifting the active stimulation electrode can fully restore functionality after the initial stimulation site degrades, prolonging the usable lifetime of the biointerface significantly. In this manner we place a key stepping stone towards building self-adjusting, low-power biointerfaces, themselves a foundational stepping stone towards adaptable, low-power bioprostheses
Photolysis of m-phenylene-bis(Chlorodiazirine)+2-vinylpyridine: does an indolizine chromophore inhibit the photolysis of a diazirine?
No full textThe photolysis of m-phenylene-bis(chlorodiazirine) in the presence of 2-vinylpyridine (VP) yields the m-phenylene-bis(indolizine) by a mechanism involving two consecutive photoreactions. Photolysis of a first diazirine ring generates a carbene which reacts with 2-VP to give, via a sequence of fast thermal reactions, a first product including both the indolizine and the chlorodiazirine moieties. Although in the lowest excited singlet state of the primary product, the excitation is localized on the indolizine unit, the photolysis of this product induces the decomposition of the second diazirine ring to give a second carbene which yields the final product via the same sequence of reactions: formation of a 2-vinylpyridinium ylide, cyclization and elimination of HCl. Analysis of the absorption and fluorescence spectra indicates that an upper excited singlet state, with the excitation localized on the diazirine ring, is only a few kJ/mol above S-1. It can therefore be populated by thermal activation of S-1 so that there is, seemingly, an endothermic intramolecular energy transfer from the indolizine moiety to the diazirine ring. (C) 2003 Elsevier B.V. All rights reserved.PT: J; CR: BATTINO R, 1983, J PHYS CHEM REF DATA, V12, P163 BONNEAU R, UNPUB J PHYS CHEM DESVERGNE JP, 2003, PHOTOCH PHOTOBIO SCI, V2, P289 GOULD IR, 1985, TETRAHEDRON, V41, P1987 GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 LERNER DA, 1977, J PHYS CHEM-US, V81, P12 LIU MTH, 1994, INT J CHEM KINET, V26, P1179 LIU MTH, 2001, 9 KYUSH INT S PHYS O MUROV SL, 1973, HDB PHOTOCHEMISTRY, P56 TOMIOKA H, 1993, CHEM LETT, P1291 VELAPOLDI RA, 1980, 26064 NAT BUR STAND ZUEV P, 1993, J AM CHEM SOC, V115, P3788 ZUEV PS, 1994, J ORG CHEM, V59, P2267; NR: 13; TC: 1; J9: J PHOTOCHEM PHOTOBIOL A-CHEM; PG: 8; GA: 741YRSource type: Electronic(1
High-tech and (or) virtual criminal proceedings: concepts, standards, perspectives
No full textЗуев Сергей Васильевич, доктор юридических наук, профессор кафедры судебной и правоохранительной деятельности, Южно-Уральский государственный университет, г. Челябинск, Россия.
Sergey V. Zuev, Doctor of Law, professor, Department of Justice and Law Enforcement, South Ural State University, Chelyabinsk, Russia.Автор обращает внимание на то, что современные информационные технологии открывают новые возможности в обработке, передаче, получении, хранении, систематизации и использовании информации в правовых сферах, в том числе в уголовном судопроизводстве, позволяя формировать доказательства в электронном виде. В связи с этим вся уголовно-процессуальная деятельность на современном этапе развития общества становится все более технологичной. Автор обосновывает, что переход на высокотехнологичный уголовный процесс потребует кардинальное переустройство всей системы, включая процедуры проведения действий и принятие решений, защиту данных, проверку и оценку доказательств, представленных в электронном виде. Следует признать, что кардинальные перемены всей системы неизбежны, юристы и граждане должны быть к этому готовы. Вместе с тем изменения не должны снижать ощущение защищенности в сфере уголовного судопроизводства. The author draws attention to the fact that modern information technology opens up new opportunities in the processing, transmission, receipt, storage, systematization and use of information in the legal fields, including criminal proceedings, allowing the formation of evidence in electronic form. In this regard, all criminal procedural activity at the present stage of the development of society is becoming more and more technological. The author justifies that the transition to high-tech criminal proceedings will require a radical restructuring of the entire system, including procedures for action and decision-making, data protection, verification and evaluation of evidence provided electronically. Admittedly, dramatic changes to the entire system are inevitable, and lawyers and citizens must be prepared for them. At the same time, changes should not reduce the feeling of security in the sphere of criminal proceedings
Enantioselective synthesis of the C1-C28 (ABCD) sector of Spongistatin 1 (Altohyrtin A) /
No full textIsbrannie Basni A.N. (Selected Fables of A.N.)
No full textA longish introduction (5-24) yields to 51 fables, the last finishing on 124. There is a T of C at the end. The bookseller assures me that this book is rare. Russia in 1935 would have been a fairly grim place . . . . Gray cloth covers.This is a hardbound book (hard cover)Language note: RussianA.N.; edited by Alexander Zuev
ChemInform Abstract: A Modular Approach to Marine Macrolide Construction. Part 3. Enantioselective Synthesis of the C1-C28 Sector of Spongistatin 1 (Altohyrtin A).
No full text
Digital information and its carriers in criminal procedure proving: development of legal regulation
No full textЗуев Сергей Васильевич – доктор юридических наук, заведующий кафедрой правоохранительной деятельности и национальной безопасности, Южно-Уральский государственный университет, г. Челябинск. E-mail: [email protected].
Zuev Sergey Vasilievich – Doctor of Sciences (Law), Head of the Department of Law Enforcement and National Security, South Ural State University, Chelyabinsk, Russian Federation. Email: [email protected].Автор рассматривает развитие российского уголовно-процессуального института по использованию электронной информации и ее носителей в доказывании по
уголовным делам. Утверждается, что данный институт берет свое начало с 2010
года, с момента принятия Федерального закона № 143-ФЗ, которым в УПК РФ была
внесена ст. 186.1 «Получение информации о соединениях между абонентами и
(или) абонентскими устройствами». С этого момента организации, осуществляющие услуги связи, стали предоставлять электронную информацию на различных
материальных носителях. Автор обосновывает перспективу развития копирования
электронной информации и многие другие вопросы обращения с электронной информацией и ее носителями. Обращается внимание на то, что уголовное судопроизводство должно развиваться с учетом современных информационных телекоммуникационных отношений в обществе.The author considers the development of the Russian Criminal Procedure Institution of using digital information and its carriers in criminal case proving. It is stated that the institution dates back to 2010 since the adoption of the Federal Law № 143-FZ, which introduced Clause 186.1 “Obtaining information about connections between subscribers and (or) subscriber units” into the RF Criminal Procedure Code. Since then, the organization providing communication services have been providing submitting information in a variety of physical media. The author proves the prospects for the development of electronic information backup and many other issues of dealing with digital information and its carriers. Attention is drawn to the fact that criminal proceedings should be developed on account of the modern information and communication relations in society
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