163,964 research outputs found
Supporting data for Polymeric medical sutures: An exploration of polymers and green chemistry
No full textFull description in Readme file.These files contain data along with associated output from instrumentation supporting all results reported in Knutson, C. M.; Schneiderman, D. K.; Yu, M.; Javner, C. H.; Distefano, M. D.; Wissinger, J. E. Polymeric medical sutures: An exploration of polymers and green chemistry. J. Chem. Educ. 2017, 94, 1761–1765. In Knutson, et. al. it was found that with new K–12 national science standards emerging, there is an increased need for experiments that integrate engineering into the context of society. Here we describe a chemistry experiment that combines science and engineering principles while introducing basic polymer and green chemistry concepts. Using medical sutures as a platform for investigating polymers, students explore the physical and mechanical properties of threads drawn from poly(ε-caprolactone) samples of different molecular masses and actual purchased absorbable and nonabsorbable medical sutures. An inquiry-based part of the experiment tasks students with designing their own experiment to probe the potential of melt blending poly(ε-caprolactone) with commercially available polylactide products in order to modify the properties of the “sutures” drawn. Through these lessons students gain an appreciation for the importance of plastics in our society and how scientists are working to develop more sustainable alternatives. Overall, this laboratory experiment provides a feasible, versatile, sophisticated laboratory experience that engages students in a relatable topic and meets many of the Next Generation Science Standards.Minnesota Pollution Control Agency (Swift 52526)NSF CHE-1413862NSF RET DMR-1559833Knutson, Cassandra M; Schneiderman, Deborah K; Yu, Ming; Javner, Cassidy H; Distefano, Mark D; Wissinger, Jane E. (2018). Supporting data for Polymeric medical sutures: An exploration of polymers and green chemistry. Retrieved from the University Digital Conservancy, https://doi.org/10.13020/D6F115
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
\u3ci\u3eMimetic Theory & Middle-Earth: Untangling Desire in Tolkien’s Legendarium\u3c/i\u3e by Matthew J. Distefano
No full textMatthew Distefano’s friendly volume extends considerably the conversation about resonances between two twentieth-century literary giants, J. R. R. Tolkien and René Girard. Distefano not only clarifies essential aspects of Tolkien’s work by reading it through the lens of Girard’s mimetic theory but also, through his particular interest in how Hobbits provide models of positive mimetic desire, highlights, extends, and one might even say enacts aspects of Girard’s theory that are easily overlooked
Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma
No full textHepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. While recent improvements in the clinical management of HCC have yielded more favorable outcomes for patients, five-year survival rates for these individuals remain poor. Effective treatment of HCC is complicated by a complex disease etiology, significant intertumoral and intratumoral heterogeneity, the frequent absence of early-stage symptoms, and a high potential for metastasis. HCC is highly refractory to chemotherapy, largely due to the acquisition of multidrug resistance, which limits effective pharmacological treatments for HCC patients. While the mechanisms underlying the development of chemoresistance in HCC are diverse, a number of recent studies have positioned long noncoding RNAs (lncRNAs) as key participants in the process. Here, we provide an overview of HCC and the obstacles posed by acquired chemoresistance and summarize the empirical evidence supporting a role for lncRNAs in the development of acquired resistance, focusing on the specific molecular mechanisms by which these molecules attenuate chemosensitivity. We also discuss the contribution of extracellular vesicles as mediators of lncRNA-induced chemoresistance. Although newly emerging, the literature has already yielded important insights into the complex mechanisms by which lncRNAs modulate chemoresistance in HCC
On parameter and structural identifiability: nonunique reconstructiability/observability for identifiable systems, other ambiguities and new definitions.
No full textA number of inconsistencies, misunderstandings and ambiguities have arisen in the recent literature regarding identifiability concepts, evidenced in part by the number of "point-counterpoint" notes and comments published on this subject. It appears that the problem is due fundamentally to a lack of a unified set of definitions. A partially new, simple and hopefully complete set of definitions is proposed here for deterministic models. They are based on an extended model, termed the "constrained structure"-appropriate for complete analysis of identifiability properties of a system. They rely minimally on special jargon and are consistent with reported definitions for notions of stochastic identifiability. Relationships with other definitions are discussed and it is also shown that an important class of identifiable models are not necessarily uniquely observable/reconstructible. The latter problem has important implications in applications
Teori dan soal-soal : sistem pengendalian dan umpan balik/ Distefano
No full text374 hal. : ill. ; 28 cm
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
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