386 research outputs found
Dynamics of Network Formation Processes in the Co-Author Model
No full textThis article studies the dynamics in the formation processes of a mutual consent network in game theory setting: the Co-Author Model. In this article, a limited observation is applied and analytical results are derived. Then, 2 parameters are varied: the number of individuals in the network and the initial probability of the links in the network in its initial state. A simulation result shows a finding that is consistent with an analytical result for a state of equilibrium while it also shows different possible equilibria.Dynamics, Network, Game Theory, Model,Simulation, Equilibrium, Complexity
Isolated propeller aeroacoustics at positive and negative thrust Author links open overlay panel
No full textUsing propellers in negative thrust conditions can potentially result in many benefits, such as a steeper descent, a reduced landing run, reduced community noise, energy regeneration, etc. However, the aerodynamics and aeroacoustics of propellers in this regime are not well understood. This paper presents an aeroacoustic analysis of an isolated propeller operating in both positive and negative thrust conditions, using scale-resolved lattice-Boltzmann very large eddy simulations and the Ffowcs Williams & Hawkings analogy. The propeller was operated at a constant tip Mach number so that any differences in tonal noise between positive and negative thrust conditions were due to changes in blade loading. Results showed that the flow separation around the blades in the negative thrust case led to a 2 to 6 times higher standard deviation in integrated thrust compared to the positive thrust case. The blade loading in the negative thrust case shows the amplitude of fluctuations up to 18% for inboard sections and up to 30% near the blade tip compared to the time-averaged loads. The noise in the propeller plane is 10 dB higher in the positive thrust regime than in the negative thrust regime at a given absolute thrust level of
. The lower noise at negative thrust is caused by two factors: the lower magnitude of the negative torque compared to the positive torque at a given thrust level and the shift of the blade loading inboard in the negative thrust condition due to the stall of the blade tip. Along the propeller axis, the negative thrust regime has 13-15 dB higher noise because of the increased broadband noise generated by the flow separation. In the negative thrust case, the noise along the propeller axis (89 dB) and propeller plane (92 dB) are comparable. However, this is not the case for the propulsive case. The comparison of noise in the vicinity of the propeller plane showed that using the propellers in negative thrust conditions allows for a steeper and quieter descent compared to a conventional descent; as long as the magnitude of the negative torque produced is equal to or less than the torque required to operate the propeller in a conventional landing
Inferring object states and articulation modes from egocentric videos
No full textWe develop algorithms for understanding objects from the point of view of interacting with them. There are two key aspects to obtaining such an understanding. First, objects can occur in different states and we need features that are sensitive to such states. Second, different objects can be articulated in different ways and we need to understand how to correctly infer their modes of articulation. We propose self and weakly supervised techniques to obtain such an understanding of objects purely through observation of how humans interact with the world around them through their hands. Our experiments on the challenging EPIC- KITCHENS dataset show the merits of using human hands as a probe for understanding objects.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-05-01The student, Rishabh Goyal, accepted the attached license on 2021-04-27 at 12:26.The student, Rishabh Goyal, submitted this Thesis for approval on 2021-04-27 at 13:39.This Thesis was approved for publication on 2021-04-28 at 09:43.DSpace SAF Submission Ingestion Package generated from Vireo submission #16585 on 2021-09-16 at 17:06:08Made available in DSpace on 2021-09-17T02:34:49Z (GMT). No. of bitstreams: 2
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Angiogenic Transformation in Human Brain Micro Endothelial Cells: Whole Genome DNA Methylation and Transcriptomic Analysis
No full textWe tested the hypothesis that endothelial capillary tube formation in 3D cultures in basement membrane extract (BME) is secondary to the altered DNA promoter methylation and mRNA expression in human brain micro endothelial cells (HBMECs). We conducted a whole-genome transcriptomic and methylation microarray and CRISPR/Cas9-mediated gene knockdown to test our hypothesis. The data demonstrated that with angiogenic transformation 1318 and 1490 genes were significantly (p < 0.05) upregulated and downregulated, respectively. We compared our gene expression data with the published databases on GEO and found several genes in common. PTGS2, SELE, ID2, HSPA6, DLX2, HEY2, FOSB, SMAD6, SMAD7, and SMAD9 showed a very high level of expression during capillary tube formation. Among downregulated gene were ITGB4, TNNT1, PRSS35, TXNIP, IGFBP5. The most affected canonical pathways were ATM signaling and cell cycle G2/M DNA damage checkpoint regulation. The top upstream regulators of angiogenic transformation were identified to be VEGF, TP53, HGF, ESR1, and CDKN1A. We compared the changes in gene expression with the change in gene methylation and found hypomethylation of the CpG sites was associated with upregulation of 515 genes and hypermethylation was associated with the downregulation of 31 genes. Furthermore, the silencing of FOSB, FZD7, HEY2, HSPA6, NR4A3, SELE, PTGS2, SMAD6, SMAD7, and SMAD9 significantly inhibited angiogenic transformation as well as cell migration of HBMECs. We conclude that the angiogenic transformation is associated with altered DNA methylation and gene expression changes.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Developmental Maturation and Alpha-1 Adrenergic Receptors-Mediated Gene Expression Changes in Ovine Middle Cerebral Arteries
No full textAbstractThe Alpha Adrenergic Signaling Pathway is one of the chief regulators of cerebrovascular tone and cerebral blood flow (CBF), mediating its effects in the arteries through alpha1-adrenergic receptors (Alpha1AR). In the ovine middle cerebral artery (MCA), with development from a fetus to an adult, others and we have shown that Alpha1AR play a key role in contractile responses, vascular development, remodeling, and angiogenesis. Importantly, Alpha1AR play a significant role in CBF autoregulation, which is incompletely developed in a premature fetus as compared to a near-term fetus. However, the mechanistic pathways are not completely known. Thus, we tested the hypothesis that as a function of maturation and in response to Alpha1AR stimulation there is a differential gene expression in the ovine MCA. We conducted microarray analysis on transcripts from MCAs of premature fetuses (96-day), near-term fetuses (145-day), newborn lambs, and non-pregnant adult sheep (2-year) following stimulation of Alpha1AR with phenylephrine (a specific agonist). We observed several genes which belonged to pro-inflammatory and vascular development/angiogenesis pathway significantly altered in all of the four age groups. We also observed age-specific changes in gene expression–mediated by Alpha1AR stimulation in the different developmental age groups. These findings imply complex regulatory mechanisms of cerebrovascular development.</jats:p
Aerodynamics and Far-field Noise Emissions of a Propeller in Positive and Negative Thrust Regimes at Non-zero Angles of Attack
No full textThis paper studies the effect of operation at non-zero angles of attack on the aerodynamic performance and far-field noise emissions of an isolated propeller operating at positive and negative thrust conditions. To achieve this, scale-resolved lattice-Boltzmann very large eddy simulations coupled with the Ffowcs Williams & Hawkings analogy have been used. The results show that when the propeller operates with a 10◦ angle of attack at the positive thrust condition, the blade loading increases on the advancing side and decreases on the retreating side, leading to a 9.6% increase in integrated thrust (when computed along the propeller axis) and a negligible increase (0.1%) in propeller efficiency. Conversely, at the negative thrust condition, the operation at 10 deg angle of attack results in a 7.9% decrease in thrust magnitude and an 11.1% reduction in energy-harvesting efficiency. In this condition, the positively cambered blade sections exhibit dynamic stall at the 10◦ angle of attack, resulting in broadband fluctuations of up to 10% of the mean loading. As a result of the opposite change in absolute blade loading in the negative thrust condition compared to the positive thrust condition at the 10◦ angle of attack, the change in the noise directivity is also the opposite. Whereas in the positive thrust case, the noise increases in the region from which the propeller is tilted away (i.e., below the propeller at a positive angle of attack), in the negative thrust case, it is the other way around. This study highlights the need to account for non-zero angles of attack in propeller design and optimization analyses
Small world: Narrow, wide, and long replication of Goyal, van der Leij and Moraga‐Gonzélez (JPE 2006) and a comparison of EconLit and Scopus
No full textI undertake a narrow, wide, and long replication of Goyal, van der Leij and Moraga‐Gonzélez (2006, https://doi.org/10.1086/500990). Using social network analysis, they show that the Economics profession gradually evolved into a small world. Small worlds (or small world networks) have unique information transmission capabilities. The trend is explained by the emergence of frequently publishing researchers with many distinct co‐authors. In a social network, they resemble stars. The original results are robust to the usage of (I) another software, (II) a recent version of the originally used data, and (III) another database and a more sophisticated author disambiguation
Small World: Narrow, Wide and Long replication of Goyal, van der Leij and Moraga-González (JPE 2006) and a Comparison of EconLit and Scopus
No full textI undertake a narrow, wide and long replication of Goyal, van der Leij and Moraga-González (Journal of Political Economy 2006; 114(2): 403–412). Using social network analysis they show that the Economics profession gradually evolved into a small world. Small worlds (or small world networks) have unique information transmission capabilities. The trend is explained by the emergence of frequently publishing researchers with many distinct co-authors. In a social network they resemble stars. The original results are robust to the usage of (I) another software, (II) a recent version of the originally used data, and (III) another database and a more sophisticated author disambiguation
Table_6_Angiogenic Transformation in Human Brain Micro Endothelial Cells: Whole Genome DNA Methylation and Transcriptomic Analysis.XLSX
No full textWe tested the hypothesis that endothelial capillary tube formation in 3D cultures in basement membrane extract (BME) is secondary to the altered DNA promoter methylation and mRNA expression in human brain micro endothelial cells (HBMECs). We conducted a whole-genome transcriptomic and methylation microarray and CRISPR/Cas9-mediated gene knockdown to test our hypothesis. The data demonstrated that with angiogenic transformation 1318 and 1490 genes were significantly (p < 0.05) upregulated and downregulated, respectively. We compared our gene expression data with the published databases on GEO and found several genes in common. PTGS2, SELE, ID2, HSPA6, DLX2, HEY2, FOSB, SMAD6, SMAD7, and SMAD9 showed a very high level of expression during capillary tube formation. Among downregulated gene were ITGB4, TNNT1, PRSS35, TXNIP, IGFBP5. The most affected canonical pathways were ATM signaling and cell cycle G2/M DNA damage checkpoint regulation. The top upstream regulators of angiogenic transformation were identified to be VEGF, TP53, HGF, ESR1, and CDKN1A. We compared the changes in gene expression with the change in gene methylation and found hypomethylation of the CpG sites was associated with upregulation of 515 genes and hypermethylation was associated with the downregulation of 31 genes. Furthermore, the silencing of FOSB, FZD7, HEY2, HSPA6, NR4A3, SELE, PTGS2, SMAD6, SMAD7, and SMAD9 significantly inhibited angiogenic transformation as well as cell migration of HBMECs. We conclude that the angiogenic transformation is associated with altered DNA methylation and gene expression changes.</p
Table_2_Angiogenic Transformation in Human Brain Micro Endothelial Cells: Whole Genome DNA Methylation and Transcriptomic Analysis.XLSX
No full textWe tested the hypothesis that endothelial capillary tube formation in 3D cultures in basement membrane extract (BME) is secondary to the altered DNA promoter methylation and mRNA expression in human brain micro endothelial cells (HBMECs). We conducted a whole-genome transcriptomic and methylation microarray and CRISPR/Cas9-mediated gene knockdown to test our hypothesis. The data demonstrated that with angiogenic transformation 1318 and 1490 genes were significantly (p < 0.05) upregulated and downregulated, respectively. We compared our gene expression data with the published databases on GEO and found several genes in common. PTGS2, SELE, ID2, HSPA6, DLX2, HEY2, FOSB, SMAD6, SMAD7, and SMAD9 showed a very high level of expression during capillary tube formation. Among downregulated gene were ITGB4, TNNT1, PRSS35, TXNIP, IGFBP5. The most affected canonical pathways were ATM signaling and cell cycle G2/M DNA damage checkpoint regulation. The top upstream regulators of angiogenic transformation were identified to be VEGF, TP53, HGF, ESR1, and CDKN1A. We compared the changes in gene expression with the change in gene methylation and found hypomethylation of the CpG sites was associated with upregulation of 515 genes and hypermethylation was associated with the downregulation of 31 genes. Furthermore, the silencing of FOSB, FZD7, HEY2, HSPA6, NR4A3, SELE, PTGS2, SMAD6, SMAD7, and SMAD9 significantly inhibited angiogenic transformation as well as cell migration of HBMECs. We conclude that the angiogenic transformation is associated with altered DNA methylation and gene expression changes.</p
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