286 research outputs found
Catheter-based renal denervation for resistant hypertension: twenty-four month results of the EnligHTN™ I first-in-human study using a multi-electrode ablation system
No full textAbstract not availableCostas P. Tsioufis, Vasilios Papademetriou, Kyriakos S. Dimitriadis, Alexandros Kasiakogias, Dimitrios Tsiachris, Matthew I. Worthley, Ajay R. Sinhal, Derek P. Chew, Ian T. Meredith, Yuvi Malaiapan, Costas Thomopoulos, Ioannis Kallikazaros, Dimitrios Tousoulis, Stephen G. Worthle
Charged fermions and strong cosmic censorship
No full textIt was recently shown that the Strong Cosmic Censorship conjecture might be violated for near-extremally-charged black holes in de Sitter space. Here, we extend our study to charged fermionic fields in the exterior of Reissner-Nordstrom-de Sitter black holes. We identify three families of modes; one related to the photon sphere, a second related to the de Sitter horizon and a third which dominates near extremality. We show that for near-extremally-charged black holes there is a critical fermionic charge below which Strong Cosmic Censorship may potentially be violated. Surprisingly enough, as one approaches extremality even more, violation of Strong Cosmic Censorship may occur even beyond the critical fermionic charge. (C) 2019 The Author. Published by Elsevier B.V
Despite Praise: Techniques of Paradoxology and Paradoxography in the Work of Kyriakos Charalambides
No full textCritics have often said that Kyriakos Charalambides’ poetry is hard and challenging even for the most cultivated and well-read reader. The author of the article examines the techniques of rhetoric style with which the poet orchestrates his inspirations: parentheses, stereotypical, corrective and introductory phrases, innuendoes, direct and indirect questions, comic scenes, etc.Critics have often said that Kyriakos Charalambides’ poetry is hard and challenging even for the most cultivated and well-read reader. The author of the article examines the techniques of rhetoric style with which the poet orchestrates his inspirations: parentheses, stereotypical, corrective and introductory phrases, innuendoes, direct and indirect questions, comic scenes, etc.À plusieurs reprises la critique a signalé que la poésie de Kyriakos Charalambidis présente beaucoup de résistances et des difficultés même pour les lecteurs les plus initiés. Dans cet article sont examinées des techniques rhétoriques de style à l’aide desquelles le poète orchestre ses inspirations poétiques: des parenthèses, des phrases stéréotypées, correctives, et annonciatrices, des sous-entendus, des questions directes et indirectes, des scènes comiques, etc
Kyriakos Mitsotakis: The Permanent Campaign Prime Minister
No full textThis chapter discusses the political background of Kyriakos Mitsotakis and evaluates his permanent campaigning at a time of the Covid-19 crisis and the resulting economic one. In particular, it examines his communication strategy from the perspective of the three categories of the permanent campaign indicators (capacity building and strategy, paid and owned media as well as earned media). It finds that Mitsotakis has so far applied permanent campaigning, to a greater degree, than any of his predecessors and thus can be considered as the ‘permanent campaign prime minister’. Moreover, he has put emphasis on all three sets of this communication strategy: capacity building and strategy, paid and owned media as well as earned media. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG
The sustainable growth paradigm : implications for technology and policy
No full textThesis (S.M. in Technology and Policy)--Massachusetts Institute of Technology, Engineering Systems Division, Technology and Policy Program, 2009.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Includes bibliographical references (leaves 102-109).While some scholars continue to insist that the concept of sustainability is vague and unwieldy, this thesis seeks to explore multidimensional elements of sustainability and seeks to offer an integrative, transdisciplinary approach to policy design for its attainment. Sustainability and the related concepts of development, globalization, and economic and environmental justice are interwoven with technological, social and institutional change, and with trade as drivers of the transformation of industrial and industrializing societies. The discussion begins by an analysis of the dominant existing models of economic growth and innovation and advances to the effects of economic growth on sustainability. Included is an analysis of the limits of the GDP growth paradigm, the effects of growth on the developed and the developing world and the relationship between economic growth and ecological collapse. The focus of analysis then shifts from the domestic to the international. Trade and the International Financial System are examined both with respect to their primary theories and characteristics, but also in relation to their effects to sustainability. The discussion is then concluded by an examination of the different policy options and analytical tools that could be employed for a transition to a more sustainable economic model.by Kyriakos Pierrakakis.S.M.in Technology and Polic
SPYRAL HTN-OFF MED study: Renal denervation in the spiral orbits of current results and future studies
No full textRelationship of urine albumin excretion to markers of systemic inflammation in patients with essential hypertension
No full textThe aim of the present study was to investigate the relationships between urinary albuminexcretion, expressed as the albumin to creatinine ratio (ACR) with diverse markers ofinflammatory activation [high-sensitivity C-reactive protein (hs-CRP), serum amyloid-Α(SAA), adiponectin, tumor necrosis factor-a (TNF-a), interleukin-18 (IL-18) and solubleCD40 ligand (sCD40L)] in non-diabetic patients with essential hypertension. Moreover,we tried to determine the differences in demographic, laboratory and clinical parametersbetween the groups of microalbuminuric and normoalbuminuric hypertensives.The entire population consisted of 308 consecutive newly-diagnosed untreated patientswith essential hypertension stageI-II [203 άνδρες, μέση ηλικία=51 έτη, αρτηριακή πίεση(ΑΠ) ιατρείου=148/95 mmHg]. Based on the mean value of ACR from two nonconsecutivespot urine samples patients were divided into two groups: those withmicroalbuminuria (MA) (ACR=30-300 mg/g, n=58) and those with normoalbuminuria(ACR<30mg/g, n=250). Moreover, blood samples were collected for the determination ofthe metabolic profile and hs-CRP, SAA, adiponectin, IL-18, TNF-a and sCD40L levels.Microalbuminurics compared to normoalbuminurics were older (54±7 vs 49±7 years,p=0.035), had greater waist circumference (104.1±11.5 vs 99±11.3 cm, p<0.05), whiledid not differ regarding sex and body mass index (p=NS). Hypertensives with MAcompared to those without MA had higher levels of office systolic BP (152±14 vs145±14 mmHg, p<0.05), 24-h systolic systolic and diastolic BP (141±16 vs 131±12mmHg and 89±11 vs 83±6 mmHg, respectively, p<0.005). Moreover, microalbuminuricscompared to normoalbuminurics were characterized by higher levels of log hs-CRP(0.69±0.2 vs 0.13±0.36 mg/l, p<0.0001), log SAA (0.73±0.24 vs 0.5±0.28 mg/dl,152p<0.0001) and lower log adiponectin (0.81±0.16 vs 0.92±0.23 μg/ml, p<0.0001)independently of confounding factors, while did not differ regarding metabolic profile,renal function and levels of IL-18, TNF-a and sCD40L (p=NS). In multiple regressionanalysis model log hs-CRP (b=0.476, vsp<0.0001), 24-h systolic BP (b=0.318, p<0.0001)waist circumference (b=0.206, p<0.0001) and log adiponectin (b=-0.145, p=0.005) wereindependent predictors of albuminuria.In conclusion, non-diabetic hypertensive patients with MA are characterixed byincreased levels of subclinical inlflammatoey activation, as reflected by the highconcentrations of hs-CRP and SAA and the low adiponectin values. Moreover, theindependent association of ACR with hs-CRP, SAA and adiponectin underscore theclose interrelationship between low-grade inflammation and albuminuria in the settingof essential hypertensionΣκοπός της παρούσας μελέτης ήταν να διερευνηθεί η συσχέτιση της ΑΑΟ, εκφραζόμενηςως ο λόγος αλβουμίνης προς κρεατινίνη (Α/Κ), με δείκτες συστηματικής φλεγμονής[υψηλής ευαισθησίας C-αντιδρώσα πρωτεΐνη (hs-CRP), αμυλοειδές-Α (SAA),αντιπονεκτίνη (adiponectin), παράγοντας νέκρωσης όγκου-α (TNF-a), ιντερλευκίνη-18(IL-18) και διαλυτό σύνδεσμο CD40 (sCD40L) σε μη-διαβητικούς ασθενείς με ιδιοπαθήαρτηριακή υπέρταση (ΑΥ). Επίσης έγινε προσδιορισμός των διαφορών σταδημογραφικά, κλινικά και εργαστηριακά δεδομένα μεταξύ των ομάδων των υπερτασικώνασθενών με μικροαλβουμινουρία και των νορμοαλβουμινουρικών υπερτασικών.Ο συνολικός πληθυσμός αποτελείται από 308 διαδοχικούς, νεοδιαγνωσθέντες ασθενείςμε ιδιοπαθή ΑΥ (στάδιο Ι-ΙΙ), οι οποίοι δε λαμβάνουν θεραπεία [203 άνδρες, μέσηηλικία=51 έτη, αρτηριακή πίεση (ΑΠ) ιατρείου=148/95 mmHg]. Βάσει της μέσης τιμήςτου Α/Κ σε 2 μη-διαδοχικά δείγματα πρωϊνών ούρων θα διαχωριστούν σε 2 ομάδες: σεασθενείς με μικροαλβουμινουρία (ΜΑ) (A/K=30-300 mg/g, n=58) και σενορμοαλβουμινουρικούς (Α/Κ<30mg/g, n=250). Επίσης ελήφθησαν δείγματα αίματοςγια καθορισμό του μεταβολικού προφίλ καθώς και των επιπέδων hs-CRP, SAA,adiponectin, IL-18, TNF-a και sCD40L.Οι μικροαλβουμινουρικοί υπερτασικοί σε σύγκριση με τους νορμοαλβουμινουρικούςήταν πιο ηλικιωμένοι (54±7 έναντι 49±7 έτη, p=0.035), παρουσίαζαν μεγαλύτερηπερίμετρο μέσης (104.1±11.5 έναντι 99±11.3 cm, p<0.05), ενώ δεν διέφεραν αναφορικάμε το φύλο και το δείκτη μάζας (p=NS). Οι ασθενείς με MA σε σύγκριση με αυτούςχωρίς MA είχαν μεγαλύτερη συστολική ΑΠ ιατρείου (152±14 έναντι 145±14 mmHg,p<0.05), 24-ωρη συστολική και διαστολική ΑΠ (141±16 έναντι 131±12 mmHg και89±11 έναντι 83±6 mmHg, αντιστοίχως, p<0.005). Επιπροσθέτως, οιμικροαλβουμινουρικοί σε σύγκριση με τους νορμοαλβουμινουρικούς χαρακτηρίζονταν150από σημαντικώς μεγαλύτερα επίπεδα log hs-CRP (0.69±0.2 έναντι 0.13±0.36 mg/l,p<0.0001), log SAA (0.73±0.24 έναντι 0.5±0.28 mg/dl, p<0.0001) και χαμηλότερεςσυγκεντρώσεις log adiponectin (0.81±0.16 έναντι 0.92±0.23 μg/ml, p<0.0001)ανεξαρτήτως συγχυτικών παραγόντων, ενώ δεν διέφεραν αναφορικά με το μεταβολικόπροφίλ τους δείκτες νεφρικής λειτουργίας καθώς και τα επίπεδα IL-18, TNF-a καιsCD40L (p=NS). Σε μοντέλο παλίνδρομης γραμμικής ανάλυσης δείχθηκε ότι η log hs-CRP (b=0.476, p<0.0001), η 24-ωρη ΣΑΠ (b=0.318, p<0.0001) και η περίμετρος μέσης(b=0.206, p<0.0001) και η log adiponectin (b=-0.145, p=0.005) ήταν ανεξάρτητοιπρογνωστικοί παράγοντες της αλβουμινουρίας.Συμπερασματικά, οι μη-διαβητικοί υπερτασικοί ασθενείς με ΜΑ παρουσιάζουναυξημένα επίπεδα υποκλινικής φλεγμονώδους διεργασίας, όπως αυτή αντανακλάταιαπό τις υψηλές τιμές hs-CRP και SAA καθώς και από τις χαμηλές συγκεντρώσεις τηςadiponectin. Επιπροσθέτως οι ανεξάρτητες συσχετίσεις της ΑΑΟ με τη hs-CRP, τοSAA και την adiponectin υπογραμμίζουν τη στενή διασύνδεση της συστηματικήςφλεγμονής και της αλβουμινουρίας στην ιδιοπαθή υπέρταση
Renal denervation vascular effects: An “insider's” view
No full textCurrently, renal denervation (RDN) has proven its overall procedural and renal safety in registries and trials. Available data, suggest that vascular complications are rather scarce in modern studies using established neuromodulation catheters of different technologies and kidney parameters are mainly maintained stable overtime in RDN patients. Identification of the impact of energy delivery at vascular level by means of advanced methodologies such as optical coherence tomography (OCT) is a meaningful research tool. This accumulation of evidence on the acute and late effects of the procedure in the renal artery tissue especially when a new catheter is tested, as in the present work can further enhance our knowledge on the pathophysiology and clinical outcome of RDN
Erratum: Multimodality Imaging in a Patient With Double Aortic Arch Undergoing Transcatheter Aortic Valve Implantation: J Am Coll Cardiol Case Rep 2024;29:102224 (JACC: Case Reports (2024) 29(5), (S2666084924000056), (10.1016/j.jaccas.2024.102224))
No full textThis article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief and Authors. The article duplicates significant parts of a paper that had already appeared in EuroIntervention 2023;19:e875-e876, 10.4244/EIJ-D-23-00346. One of the conditions of submission of a paper for publication is that authors declare explicitly that the paper has not been previously published and is not under consideration for publication elsewhere. Re-use of any data should be appropriately cited. As such this article represents a misuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process. © 2024 The Author
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