1,413 research outputs found
Hydroxamic acid - A novel molecule for anticancer therapy
No full textHydroxamic acid is a potent moiety not only in the field of cancer therapy but also as a mutagenic agent. Among the various derivatives of hydroxamic acid, SAHA (Suberoylanilide Hydroxamic Acid) is considered as a potent anticancer agent. Scientists from the different corner synthesized different hydroxamic acid moieties with some straight chain oxazole, thiadiazole, biphenyl moieties in the terminal position. Acetylation and deacetylation of histones of the core proteins of nucleosomes in chromatin play an important role in the regulation of gene expression. The level of acetylation of histones is established and maintained by two classes of enzymes, histone acetyltransferase and histone deacetylases, which have been identified as transcriptional coactivators and transcriptional corepressors, respectively. There is increasing evidence that aberrant histone acetylation has been linked to various malignant diseases. Great efforts are currently underway for the design of more potent and less toxic candidates for the treatment of cancer. In recent years, hydroxamic acid derivatives have attracted increasing attention for their potential as highly efficacious in combating various etiological factors associated with cancer. Our main intention to draw an attention is that this single functional moiety has not only fit in the receptor but also create a diversified activity
Plastid Genotyping Reveals the Uniformity of Cytoplasmic Male Sterile-T Maize Cytoplasms
No full textCytoplasmic male-sterile (CMS) lines in maize (Zea mays) have been classified by their response to specific restorer genes into three categories: cms-C, cms-S, and cms-T. A mitochondrial genome representing each of the CMS cytotypes has been sequenced, and male sterility in the cms-S and cms-T cytotypes is linked to chimeric mitochondrial genes. To identify markers for plastid genotyping, we sequenced the plastid genomes of three fertile maize lines (B37, B73, and A188) and the B37 cms-C, cms-S, and cms-T cytoplasmic substitution lines. We found that the plastid genomes of B37 and B73 lines are identical. Furthermore, the fertile and CMS plastid genomes are conserved, differing only by zero to three single-nucleotide polymorphisms (SNPs) in coding regions and by eight to 22 SNPs and 10 to 21 short insertions/deletions in noncoding regions. To gain insight into the origin and transmission of the cms-T trait, we identified three SNPs unique to the cms-T plastids and tested the three diagnostic SNPs in 27 cms-T lines, representing the HA, I, Q, RS, and T male-sterile cytoplasms. We report that each of the tested 27 cms-T group accessions have the same three diagnostic plastid SNPs, indicating a single origin and maternal cotransmission of the cms-T mitochondria and plastids to the seed progeny. Our data exclude exceptional pollen transmission of organelles or multiple horizontal gene transfer events as the source of the mitochondrial urf13-T (unidentified reading frame encoding 13-kD cms-T protein) gene in the cms-T cytoplasms. Plastid genotyping enables a reassessment of the evolutionary relationships of cytoplasms in cultivated maize.Peer reviewe
EGA/VGA to TV (PAL) conversion
No full textNowadays two of the most popular professional computer graphics cards for the PC (Personal Computer) are the EGA (Enhanced Graphics Adapter) and the VGA (Video Graphics Array) cards. These two graphics cards features relative high resolution and colors. Of different reasons it’s interesting to have the possibility to connect a PC with one of these graphics cards to a PAL (Phase Alternate Line) system television-set. However this is not possible because of different horizontal and vertical synchronization (the horizontal and vertical synchronization pulses dictate the scan rate of the display, i.e. computer monitor resp. television screen) of the EGA/VGA cards and the PAL system. In this report a way will be discussed in which this EGA/VGA to PAL conversion can be realized. By manipulating, i.e. refill with new values, the registers in charge of the synchronization on the EGA/VGA cards so that a PAL compatible signal can be achieved. This solution, based on register manipulation, gives a relative good picture on the television screen if alphanumeric characters are present on the computer. With graphics the conversion was not possible with this solution.The conclusion is that this method can be used only if alphanumeric characters are to be displayed on a television screen.Electrical Engineering, Mathematics and Computer ScienceTelecommunicatie- en Verkeersbegeleidingssysteme
A pal, Lue to Dear James (6 October 1962)
No full textSigned by A pal, Luehttps://egrove.olemiss.edu/mercorr_pro/1089/thumbnail.jp
On Axiomatizations of PAL
No full textIn the literature, different axiomatizations of Public Announcement Logic (PAL) were proposed. Most of these axiomatizations share a 'core set' of the so-called reduction axioms. In particular, there is a composition axiom which stipulates how two consecutive announcements are composed into one. In this paper, by designing non-standard Kripke semantics for the language of PAL, we show that without the composition axiom the core set does not completely axiomatize PAL. In fact, most of the intuitive 'axioms' and rules we took for granted could not be derived from the core set. The non-standard semantics we proposed is of its own interest in modelling realistic agents. We show that with the help of different composition axioms we may axiomatize PAL w.r.t. such non-standard semantics.Computer Science, Artificial IntelligenceComputer Science, Theory & MethodsMathematics, AppliedEICPCI-S(ISTP)
Realisatie van PAL-coder t.b.v. elektronisch schoolbord
No full textRe gerealiseerde schakeling is een sterk gereduceerde PAL-coder, afgeleid van een PALcoder zoals die voor T.V.- doeleinden wordt gebruikt. Er kan gekozen worden uit vier kleuren voor de weergave van gekleurde lijnen tegen een gekleurde achtergrond. De kleurvektoren zijn orthogonaal en vertegenwordigen de kleuren blauw, rood, geel en groen.Electrical Engineering, Mathematics and Computer ScienceTransmissie van Informati
Pal Interpolation of Integral Types
No full textIn this paper, the author(s) discuss existence and uniqueness results of three so-called integral types of Pal interpolation schemes which are interesting extensions/ generalizations of classical Hermite-Fejer Interpolation problem. The results are of interest to approximation theory
A PRELIMINARY STUDY ON THE IN VITRO ANTIOXIDANT ACTIVITY OF THE STEMS OF OPUNTIA VULGARIS
No full textThe in vitro antioxidant activity of stems of Opuntia vulgaris Mill had been investigated by estimating degree of non-enzymatic haemoglobin glycosylation measured colorimetrically at 520 nm. It was found that benzene and chloroform extract of O. vulgaris had better antioxidant activity than petroleum ether, ethyl acetate, ethanol and aqueous extract. The antioxidant activity of the extracts was concentration dependent and comparable to that of D-- tocopherol (vitamin E) and ascorbic acid (vitamin C), standard antioxidant compounds used
Librarians and Statistics: Thoughts on a Tentative Relationship
No full textLibrarians are not trained as original researchers during library school. As a result, librarians as authors may succumb to common statistical misconceptions and use errors, thus it is important for librarians to know how to recognize them. A quick discussion of what a researcher should be aware to avoid poor methods and inaccurate use of statistics is included. A review of statistics and research methods courses currently offered in library and information science programs helps determine if the lack of training observed in earlier studies has changed. A list of recommendations for authors and reviewers of LIS literature is presented
Dietary-induced cancer prevention: An expanding research arena of emerging diet related to healthcare system
No full textDiet plays a vital role in the management of cancer because they are the source of important physiologically functional components. Scientific observations support the idea that dietary supplement can prevent breast cancer recurrences. Strong correlations are established between the high intake of saturated fat and the incidence of different types of cancer. It is found that chronic alcohol consumption is associated with increased risk of cancers of oral cavity, pharynx, esophagus, and larynx. Again, some evidences are also found regarding phosphorous, glutamate level in the body, and incidence of cancer. Different physiologically functional components are found in the dietary materials. Fibers, the major dietary components, have long been recognized for the unique properties in the treatment of cancer, which are related to its antineoplastic functions. Antioxidant rich diet has been added to the list of cancer-preventing dietary components. Also, recently published research has shown that natural carotenoids in the diet leads to a normalization of body epithelial cells and protects against the risk of stomach and esophagus cancer, and improves the immune system′s response. Again, fruit juices, processed vegetable juices, orange peel, green tea, vitamins, flavonoids, and trace materials have cancer inhibitory properties. Clearly, there has been increasing recognition of chemoprotective functions. Now, it can be recognized for another kind of functionality for the improvement of the health of mankind
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