3 research outputs found
VALIDITY AND RELIABILITY OF 'ON PROTRACTOR' SMARTPHONE APPLICATION FOR MEASUREMENT OF CRANIOVERTEBRAL AND CRANIO-HORIZONTAL ANGLE
No full textBackground: Measuring angles and movement is an important aspect of clinical assessment. Over the years, various methods have been used to measure the angles. Image based smartphone goniometer offers an easy and non-invasive method for measuring craniovertebral and cranial horizontal angle. However, the validity of this approach has not been established yet. The purpose of this study was to investigate the validity and reliability of a smartphone based application, by comparing the results of the application and ‘AutoCAD®’ software.
Methods: Convenient sampling of asymptomatic participants (Males=4 and females =16) who met the inclusion criteria were examined by two researchers for craniovertebral (CVA) and cranial horizontal angle (CHA) using ON Protractor smartphone application and ‘AutoCAD®’ software. The third examiner analyzed the anthropometric and descriptive data. Validity and reliability were measured using intraclass correlation coefficients (ICC) and p-value.
Result: Good to excellent Intra-rater and inter-rater reliability was demonstrated for CVA and CHA when ON Protractor mobile application and AutoCAD® were compared, with ICC values 0.879 and 0.991 respectively.
Conclusion: Smartphone mobile application-ON Protractor is a reliable tool to measure craniovertebral and cranial horizontal angle
PGC-1a in muscle links metabolism to inflammation
No full text1. In higher eukaryotes, metabolism and immunity are tightly coupled. However, whereas in evolutionary terms, a compromised immune response due to undernourishment has been the predominant problem, the inflammatory response to obesity and other life style-associated diseases has increased in relevance in Western societies in the last hundred years. 2. Traditionally, fat tissue has been considered as the major source of pro-inflammatory secreted factors in these pathologies. In recent years however, the contribution of other tissues to a disease-causing chronic inflammation has been increasingly appreciated. 3. The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is one of the key regulatory factors in the active skeletal muscle. Aberrant expression of PGC-1α in inactive muscle fibres could link a sedentary life style, persistent systemic inflammation and the higher risk for many chronic diseases. Modulation of PGC-1α activity in skeletal muscle might accordingly have a broad therapeutic effect. Here, recent advances in the understanding of the role of muscle PGC-1α in health and disease are reviewed
