1,720,998 research outputs found
The Janus face of BNP therapy in chronic heart failure: beneficial effects unmasked by β blockers?
No full text
Function and regulation of serine/threonine phosphatases in the healthy and diseased heart
No full textProtein phosphorylation is a major control mechanism of a wide range of physiological processes and plays an important role in cardiac pathophysiology. Serine/threonine protein phosphatases control the dephosphorylation of a variety of cardiac proteins, thereby fine-tuning cardiac electrophysiology and function. Specificity of protein phosphatases type-1 and type-2A is achieved by multiprotein complexes that target the catalytic subunits to specific subcellular domains. Here, we describe the composition, regulation and target substrates of serine/threonine phosphatases in the heart. In addition, we provide an overview of pharmacological tools and genetic models to study the role of cardiac phosphatases. Finally, we review the role of protein phosphatases in the diseased heart, particularly in ventricular arrhythmias and atrial fibrillation and discuss their role as potential therapeutic targets. (C) 2013 Elsevier Ltd. All rights reserved
Development of molecular imaging tools to investigate protein phosphatase type-1 and type-2A localisation and dynamics in living cells
No full textGenetic deletion of phosphatase inhibitor-1 versus betablocker treatment in severe CaMKIIdeltaC-induced heart failure
No full textGenetic deletion of phosphatase inhibitor-1 versus betablocker treatment in severe CaMKIIdeltaC-induced heart failure
No full text
- …
