17 research outputs found
Synthesis of novel substituted 3-(4-((1H-benzo[d]imidazol-2-ylthio)methyl)-1-phenyl-1H-pyrazol-3-yl)-2H-chromen-2-ones: various approaches
No full textA facile and expedient microwave-assisted solvent-free method for the synthesis of 2-amino-4-(2-oxo-2H-chromen-3-yl)nicotinonitriles
No full textChemInform Abstract: Efficient Stepwise and One Pot Three‐Component Synthesis of 2‐Amino‐4‐(2‐oxo‐2H‐chromen‐3‐yl)thiophene‐3‐carbonitriles.
No full textPEG-600 mediated one-pot reaction of 3-acetyl-2H-chromen-2-one with heterylthiols and phenylthioureas using tetrabutylammonium tribromide as an efficient green reagent
No full textA simple method for the one-pot reaction of 3-acetyl-2H-chromen-2-one with different heterylthiols and phenylthioureas under green conditions using tetrabutylammonium tribromide (TBATB) as an efficient reagent has been described.</p
An efficient one-pot three-component synthesis of 2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)-3-arylacrylonitriles and their cytotoxic activity evaluation with molecular docking
No full textA facile, convenient and one-pot three-component method has been outlined for the synthesis of title compounds by treating equimolar amounts of 3-(2-bromoacetyl)-2H-chromen-2-one (2) with 2-cyanothioacetamide (3) and various aryl/heteryl aldehydes (5 or 7) independently. The effect of solvent and catalyst on this one-pot reaction has been studied and the use of l-proline in ethanol was found to be effective to achieve the target compounds (6 & 8) in fair yields. These synthesized compounds were further assessed for the anti-hepatoma activity, and their action mechanism was also investigated by using molecular docking studies. All the compounds 6(a-h) & 8(a-f) manifested excellent potency for anti-hepatoma activity. It should be noted that, compounds 6e, 6f have exhibited almost equipotent activity with reference to standard drug Nexavar. Keywords: One-pot three-component reaction, l-Proline, Eco-friendly method, Molecular docking, Anti-hepatoma studie
ChemInform Abstract: Synthesis of 3‐Substituted Coumarins: An Efficient Green Approach Using L‐Proline as Catalyst in Triethanolamine Medium.
No full textSynthesis, anti-microbial activity and docking studies of 3-(2-(phenylamino)thiazol-4-yl)-2<i>H</i>-chromen-2-ones and ethyl 2-(2-(phenylamino)thiazol-4-yl)acetates
Get PDF96-105Different approaches for the synthesis of a series of 3-(2-(phenylamino)thiazol-4-yl)-2H-chromen-2-ones 5a-h is described. Also, 5a-h can be prepared by the reaction of salicylaldehyde with ethyl 2-(2-(phenylamino)thiazol-4-yl)acetates 6a-h which in turn are prepared by the reaction of ethyl 4-chloroacetoacetate with phenylthioureas. All the compounds 5a-h and intermediates 6a-h prepared in this work have been screened for their antimicrobial activities such as anti-bacterial and anti-fungal. Compounds 6e, 6g and 6h show good anti-bacterial activity. The molecular interaction of the synthesized compounds 6a-h with S. aureus FtsZ protein is supported by molecular docking studies
Speed-Torque Coupled Modular Energy Management for HEVs
No full textFuel consumption reduction in Hybrid Electric Vehicles (HEV) powertrains has been an important area of research over the past few decades. HEV powertrains have two energy sources : fuel and battery. The important task of splitting the energy/power demand between both these sources is performed by the Energy Management Systems (EMS). There are many EMS methods and the focus ofthis thesis is on a method called Modular ECMS (MEMS) implemented by TNO. MEMS finds the optimal power split among the subsystems by minimizing the energy loss in each subsystem. This strategy assumes that the operating speed of the subsystems of the powertrains is known and uses this knowledge to find the optimal power split and torque among these subsystems. The objective of this thesis is to find the optimal operating speed of the subsystems as well. This is done by a least squares fitting of the objective function and constraints as functions of subsystems speed and torque. A revised Optimal Control Problem (OCP) is formulated as a quadratic programming problem of speed and torque and is termed as Speed-Torque Coupled MEMS (ST-MEMS). The ST-MEMS algorithm is tested on a series-hybrid wheel loader powertrain model and its performance is compared to MEMS, with the model and data provided by TNO. It is concluded that the ST-MEMS, while adding the speed and torque bounds as degrees of freedom, does not achieve a good distribution of power between the 2 sources. The reason for this behaviour is analyzed and an alternate approachis suggested for future work.Mechanical Engineering | Systems and Contro
Modelling Magnetocaloric Heat Pumps
No full textMagnetocaloric heat pumps are those types of heat pumpswhich use a solidMagnetoCaloricMaterial (MCM) in place of a refrigerant to provide the work for the heat pump. MCMs are materials whose temperature changes on the application or removal of a magnetic field. This effect is known as the MagnetoCaloric Effect (MCE). Magnetocaloric heat pumps have the potential in replacing the conventional vapour compression technology for Dutch dwellings, since they have minimum environmental impact due to the absence of the coolant fluids that can harm the environment. A model of the regenerator of the magnetocaloric heat pump is developed in this project having in mind the application of this type of heat pumps to Dutch dwellings. The magnetic field that is used in the development of the model is 0.875 T, with permanent magnets being the source of the magnetic field. A sensitivity analysis is carried out in order to obtain the methods to optimize the regenerator for improving the performance of the heat pump. The performance of the heat pump is measured through its average cooling capacity, average heating capacity, temperature span and Coefficient of Performance (COP) for heating. TheMCM used for the regenerators is Gd with a totalmass of 1.18 kg. The parameter that influences the performance of the heat pump the most is the porosity of the regenerator. The heat losses through the casing have the least impact on the performance of the regenerator. The frequency of the cycle also has a profound impact on the heating capacity and cooling capacity up to temperature spans of around 18 K, but it does not have such an impact on the heating COP. After increasing the frequency, decreasing the particle diameter and decreasing the porosity, the heating capacity and the temperature span are optimized. For a temperature span of 15 K, the heating capacity is 164.2W, and for a temperature span of 20 K, the heating capacity is 99.1W.Mechanical Engineering | Energy and Process Technolog
