5,195 research outputs found
Deutliche und gründliche Erklärung der Adelichen und Ritterlichen freyen Fecht-Kunst : Lectionen auff den stoß/ und deren gebrauchs eigentlicher Nachricht. Auff die rechte Italianische Art und manir, in dieses Tractätlein verfaßt/ und mit nothwendigen Kupfferstücken nach möglichkeit gezieret und vor Augen gestelt / Durch Jeann Daniel L'Ange ...
No full textThe Family History Of Daniel C. Hodges
No full textThe Family History of Daniel C. Hodges 21 April 2018
Daniel Clayton Hodges authored this family history as part of the course requirements for HIST 550/700 Your Family in History offered online in Spring 2018 and was submitted to the Pittsburg State University Digital Commons. Please contact the author directly with any questions or comments: [email protected]
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
Organoids as a Model for Intestinal Ion Transport Physiology
No full textThe advent of intestinal organoid culture in 2009 was a fortuitous development in the search for a valid marker of intestinal stem cells, and provided proof of murine intestinal stem cell regenerative potential. Intestinal organoid culture was preceded by key discoveries of the Wnt/β-catenin signaling pathway and the development of 3D culture matrices. The latter, involving a laminin-rich gel to provide an artificial basement membrane, was instrumental to primary intestinal epithelial culture by preventing anoikis, an immediate apoptotic event when intestinal epithelial cells detach from the basement membrane. One of the first physiological studies using 3D murine “mini-gut” structures showed cystic fibrosis transmembrane conductance regulator (CFTR) expression and anion channel activity in the crypt-like structures projecting from the epithelial-lined central cavity. Detailed investigations of ion transport physiology using human intestinal organoids, both primary and iPSC-derived, found close similarities to existing knowledge of ion transport physiology and included the development of the forskolin-induced swelling assay (FIS). The FIS assay using organoids cultured from rectal biopsies of cystic fibrosis patients provided an avenue for personalized medicine to test small-molecule modulators on different CFTR mutations. More recent research has led to the development of 2D primary intestinal epithelial monolayers, which provide easy access to the apical, lumen-facing membrane and the opportunity for traditional ion transport studies with Ussing chambers. Human 2D primary intestinal monolayers also demonstrate the dominance of CFTR in anion secretion and provide a quantitative evaluation of its chloride and bicarbonate secretory conductances. These aspects of ion transport physiology using 2D and 3D intestinal cultures are discussed along with the relative advantages and disadvantages of each culture method with respect to technical aspects and recapitulation of native intestinal epithelium
Ethnic identity, political identity and ethnic conflict: simulating the effect of congruence between the two identities on ethnic violence and conflict
No full textThis thesis outlines and presents an alternative hypothetical process to the emergence of ethnic conflict. Ethnic conflicts, rather than being dependent upon pre-existing 'ancient hatreds', are instead the result of a congruence between ethnic and political identity which grants individuals the ability to use ethnicity to identify and eliminate political threats. This hypothesis is formed by the examination of three case studies of ethnic conflict: Lebanon, Northern Ireland and Croatia. This hypothesis is then formalised and tested using an agent based simulation in which agent interactions are dependent upon ethnic and political identity and the congruence between the two. As predicted there was a strong positive correlation between how accurately ethnic identity reflected political identity and the level of ethnically motivated violence in the simulation, although the relationship was not linear. Furthermore the effect of a shift in congruence was found to be roughly comparable to the effect of initialising agents with a moderate level of pre-existing ethnic antagonism
Replication Data for: Interests, Information and Minority Influence in Deliberation
No full textThis data and code are to replicate the findings in "Interests, Information and Minority Influence in Deliberation." Please email the author at [email protected] or [email protected] with any questions
Replication Data for: Interests, Information and Minority Influence in Deliberation
No full textThis data and code are to replicate the findings in "Interests, Information and Minority Influence in Deliberation." Please email the author at [email protected] or [email protected] with any questions
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