43 research outputs found
Correction: Metabolic syndrome increases the risk of upgrading and upstaging in patients with prostate cancer on biopsy: a radical prostatectomy multicenter cohort study (Prostate Cancer and Prostatic Diseases, (2018), 21, 3, (438-445), 10.1038/s41391-018-0054-9)
No full textThe original version of this Article contained an error in the spelling of the authors Cosimo De Nunzio, Aldo Brassetti, Giuseppe Simone, Riccardo Lombardo, Riccardo Mastroianni, Devis Collura, Giovanni Muto, Michele Gallucci and Andrew Tubaro, which were incorrectly given as De Nunzio Cosimo, Brassetti Aldo, Simone Giuseppe, Lombardo Riccardo, Mastroianni Riccardo, Collura Devis, Muto Giovanni, Gallucci Michele and Tubaro Andrea. This has now been corrected in both the PDF and HTML versions of the Article
Guillem Godi, Si·l gen cors d’estieu es remas (BdT 219.1)
No full textThis article offers a new edition, based on Occitan Chansonnier R, of the canso-sirventes Si·l gen cors d’estieu es remas by the troubadour Guillem Godi. Moving from a textual and documentary analysis, as well as a material-philological perspective, the lectura proposes a later date for the composition (late 13th-early 14th century); moreover, a possible identification of the author with the cardinal Guillem de Peire Godin (1260-1336) is cautiously suggested
"Sens e razos d'una escriptura". La teatralità del meraviglioso nel Vangelo occitano di Nicodemo
No full textThe article presents the results of the study of Marvelous in the Occitan poem Sens e razos d’una escriptura. The poem opens with a translation in 2144 verses of the Evangelium Nicodemi; it then proceeds to relate the story of the Antichrist and a list of the Fifteen Signs which are to precede the Last Judgement. Beside an ‘objective marvelous’ (the so-called ‘Christian Marvelous’), basing on the investigation of the vocabulary the author identifies a form of ‘theatrical marvelous’, exemplified in the tales (miracula and exempla) embedded in the text. Therefore, the apocryphal source proves to be a great tool for new reflections on the medieval merveilleux
Stage-specific impact of extended versus standard pelvic lymph node dissection in radical cystectomy
No full textMetabolic syndrome is associated with advanced prostate cancer in patients treated with radical retropubic prostatectomy. Results from a multicentre prospective study
No full textBACKGROUND: Prostate cancer (PCa) is the most common non-skin cancer in USA and the second leading cause of cancer death in Western Countries. Despite the high mortality associated with PCa, the only established risk factors are age, race and family history. A possible association between metabolic syndrome (MetS) and PCa was firstly described in 2004 and several subsequent studies in biopsy cohorts have shown conflicting results. Aim of our multicentre prospective study was to investigate the association between MetS and PCa in men undergoing radical prostatectomy (RP).
METHODS: From January 2012 to June 2015, 349 consecutive men undergoing RP for PCa at three centres in Italy were enrolled into a prospective database. Body Mass Index (BMI) as well as waist circumference was measured before RP. Blood samples were also collected and tested for total PSA, fasting glucose, triglycerides and HDLs. Blood pressure was also recorded. We evaluated the association between MetS, defined according to Adult Treatment Panel III, PCa stage (advanced stage defined as pT ≥ 3 or N1) and grade (high grade defined as Gleason Score ≥ 4 + 3) using logistic regression analyses.
RESULTS: Median age and preoperative PSA levels were 66 years (IQR: 61-69) and 7 ng/ml (IQR: 5-10), respectively. Median BMI was 26.12 kg/m(2) (IQR 24-29) with 56 (16 %) obese (BMI ≥ 30 kg/m(2)) patients and 87 (25 %) patients with MetS. At pathological evaluation, advanced PCa and high-grade disease were present in 126 (36 %) and 145 (41.5 %) patients, respectively. MetS was significantly associated with advanced PCa (45/87, 51 % vs 81/262, 31 %; p = 0.008) and high-grade disease (47/87, 54 % vs 98/262, 37 %; p = 0.001). On multivariable analysis, MetS was an independent predictor of pathological stage ≥ pT3a or N1 (OR: 2.227; CI: 1.273-3.893; p = 0.005) and Gleason score ≥ 4 + 3 (OR: 2.007, CI: 1.175-3.428; p = 0.011).
CONCLUSIONS: We firstly demonstrated in a European radical retropubic prostatectomy cohort study that MetS is associated with an increased risk of high-grade and advanced prostate cancer. Further studies with long term follow-up should evaluate the impact of Mets on PCa survival
Development and external validation of lymph node density cut-off points in prospective series of radical cystectomy and pelvic lymph node dissection
No full textPD61-11 THE NEW EPSTEIN GLEASON SCORE CLASSIFICATION SIGNIFICANTLY REDUCES UPGRADING IN PROSTATE CANCER PATIENTS
No full textLaparoscopic Microwave Ablation and Enucleation of Small Renal Masses: Preliminary Experience
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Serum levels of chromogranin are not predictive of poorly differentiated prostate cancer: Results from a multicenter radical prostatectomy cohort
No full textRecently a possible link between elevated Chromogranin A (CgA) levels and poorly differentiated prostate cancer has been proposed. The aim of our study was to explore the association of CgA levels and the risk of poorly differentiated prostate cancer (PCa) in men undergoing radical retropubic prostatectomy (RRP)
