509 research outputs found
A Case Study in Application of Vectors in Three Dimensional Spaces
No full textThis paper presents a concept of vectors in three dimensional space and it will start by introducing the subject matter as well as giving a brief history on vectors in three dimensional space. This paper also gives different examples of vectors in three dimensional space and how they can be used to solve various real life problems. This concept have many applications in physics and engineering. For instance Vectors in space can be used to represent the physical force and velocity. S. Sathyapriya | D. Harshini Devi | N. Priyanka "A Case Study in Application of Vectors in Three Dimensional Spaces" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-3 , April 2018, URL: https://www.ijtsrd.com/papers/ijtsrd10887.pd
R19. Investigation of Taste Masking Efficiency of Caffeine Citrate by Lipids Utilizing Hot Melt Extrusion Technology
No full textCorresponding author (Pharmaceutics and Drug delivery): Priyanka Srinivasan, [email protected]://egrove.olemiss.edu/pharm_annual_posters/1018/thumbnail.jp
Tidal bores, catastrophic flooding in Bangladesh, and the potential usefulness of causeways
No full textThrough discussion of the worldwide devastation that tidal bores can cause, author Priyanka Joseph, examines the causes and the possible solutions to prevent these destructive waves. The pros and cons of each solution (such as causeways, viaducts, and regulators) are debated as well as their effect on the surrounding areas and environment
Study of Marine Natural Products as Anti-SARS-CoV-2 Agents Using Molecular Modeling
No full textCorresponding author (BioMolecular Sciences): Priyanka Samanta, [email protected]://egrove.olemiss.edu/pharm_annual_posters_2022/1018/thumbnail.jp
Distributed human computation framework for linked data co-reference resolution
No full textDistributed Human Computation (DHC) is a technique used to solve computational problems by incorporating the collaborative effort of a large number of humans. It is also a solution to AI-complete problems such as natural language processing. The Semantic Web with its root in AI is envisioned to be a decentralised world-wide information space for sharing machine-readable data with minimal integration costs. There are many research problems in the Semantic Web that are considered as AI-complete problems. An example is co-reference resolution, which involves determining whether different URIs refer to the same entity. This is considered to be a significant hurdle to overcome in the realisation of large-scale Semantic Web applications. In this paper, we propose a framework for building a DHC system on top of the Linked Data Cloud to solve various computational problems. To demonstrate the concept, we are focusing on handling the co-reference resolution in the Semantic Web when integrating distributed datasets. The traditional way to solve this problem is to design machine-learning algorithms. However, they are often computationally expensive, error-prone and do not scale. We designed a DHC system named iamResearcher, which solves the scientific publication author identity co-reference problem when integrating distributed bibliographic datasets. In our system, we aggregated 6 million bibliographic data from various publication repositories. Users can sign up to the system to audit and align their own publications, thus solving the co-reference problem in a distributed manner. The aggregated results are published to the Linked Data Cloud
Assessing MSI Status in GI Cancers (Rectal, Gastric, and Colon Cancer): A Cross-Sectional Study
No full textNot Availabl
The Oxygen A Band
No full textThe oxygen A band is used for numerous atmospheric experiments, but spectral line parameters that sufficiently describe the spectrum to the level required by OCO2 and other high precision/accuracy experiments are lacking. Fourier transform spectra from the Jet Propulsion Laboratory and cavity ring down spectra from the National Institute of Standards and Technology were fitted simultaneously using the William and Mary multispectrum nonlinear least squares fitting technique\footnote{D.~Chris Benner, C.~P.~Rinsland, V.~M.~Devi, M.~A.~H.~Smith, and D.~Atkins, JQSRT 1995;53:705-21.} into a single solution including the entire band. In addition, photoacoustic spectra already available from the California Institute of Technology will be added to the solution. The three types of spectrometers are complementary allowing the strengths of each to fill in the weaknesses of the others. With this technique line positions, intensities, widths, shifts, line mixing, Dicke narrowing, temperature dependences and collision induced absorption have been obtained in a single physically consistent fit.\footnote{Part of the research described in this paper was performed at The College of William and Mary, the, Jet Propulsion Laboratory, California Institute of Technology, under contracts and cooperative agreements with the National Aeronautics and Space Administration and the Jet Propulsion Laboratory. Support for the National Institute of Standards and Technology was provided by the NIST Greenhouse Gas Measurements and Climate Research Program and a NIST Innovations in Measurement Science (IMS) award.}Made available in DSpace on 2014-09-17T16:55:11Z (GMT). No. of bitstreams: 3
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Correlation between Standardized Uptake Values and Ki-67 in Different Cancers
No full textTitle:
Correlation between Standardized Uptake Values and Ki-67 on PET Scan in Different Cancers
Introduction:
Cancer is a leading cause of morbidity and mortality worldwide. Accurate assessment of tumor aggressiveness is crucial for prognosis and treatment planning. Two widely used markers are Ki-67, a nuclear protein indicating cellular proliferation, and Standardized Uptake Value (SUV) derived from FDG-PET scans, which reflects tumor metabolic activity. This study aims to evaluate the correlation between SUV and Ki-67 across different cancers to determine whether SUV can serve as a non-invasive surrogate marker for tumor proliferation.
Objectives:
• To determine the correlation between SUV on PET scan and Ki-67 expression in different types of cancers.
• To assess whether SUV can predict tumor proliferative index (Ki-67).
• To explore the influence of demographic variables such as age and gender on SUV and Ki-67 correlation.
Methodology:
A cross-sectional study was conducted at Jinnah Postgraduate Medical Center, Karachi, from [Oct 2024 to march 2025]. A total of 94 patients with histologically confirmed malignancies who underwent FDG-PET scans and Ki-67 immunohistochemistry were included. Patients who had received prior chemotherapy or radiotherapy were excluded. Data on age, gender, SUV (max), and Ki-67 index were collected. Correlation and regression analyses were performed using SPSS version 25.
Results:
A statistically significant positive correlation was found between SUV and Ki-67 index (p < 0.05), with the strongest association observed in breast Cancer, lung cancer, B Cell lymphoma. Multivariate regression revealed that Ki-67 and age significantly predicted SUV values. Female patients, particularly those with breast cancer, showed a stronger SUV–Ki-67 correlation compared to males.
Conclusion:
SUV on PET scan shows a significant correlation with Ki-67 index, suggesting its potential as a non-invasive marker of tumor proliferation. Incorporating SUV into clinica
Cenchrus ciliaris RepeatExplorer Priyanka Rathore, Bhat, Schwarzacher, Heslop-Harrison, Tomaszewska
No full textThe repetitive DNA sequence landscape and DNA methylation in chromosomes of an apomictic tropical forage grass, Cenchrus ciliaris Abstract
RepeatExplorer supplementary data for manuscript:
Priyanka Rathore1, Paulina Tomaszewska[H(1] [ST(2] 2,3, Trude Schwarzacher2,4, J.S. (Pat) Heslop-Harrison2,4,* and Vishnu Bhat1
1)Department of Botany, Faculty of Science, University of Delhi, Delhi, India
2)Department of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, United Kingdom
3)Department of Genetics and Cell Physiology, Faculty of Biological Sciences, University of Wrocław, 50-328 Wrocław, Poland
4)Key Laboratory of Plant Resources Conservation and Sustainable Utilization / Guangdong Provincial, Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China
*)Corresponding author. E-mail: [email protected] and [email protected]
Cenchrus ciliaris is an apomictic, allotetraploid pasture grass widely distributed in tropical and subtropical regions of Africa and Asia. In this work, we aim to investigate the genomic organization and characterize the nature of repetitive DNA sequences in this species. Because of the apomictic propagation, various aneuploid genotypes are found and we analysed here a 2n=4×+3=39 accession. The physical mapping of Ty1-copia and Ty3-gypsy retroelements through fluorescence in situ hybridization with global assessment of 5-methylcytosine DNA methylation through immunostaining revealed the genome-wide distribution pattern of retroelements and their association with DNA methylation. About a third of Ty1-copia sites overlapped or spanned centromeric DAPI positive heterochromatin, while the centromeric regions and arms of some chromosomes were labeled with Ty3-gypsy. Most of the retroelement sites overlapped with 5-methycytosine signals, except some Ty3-gypsy on the arms of chromosomes which did not overlap with anti-5-mC signals. Universal retrotransposon probes did not distinguish genomes of C. ciliaris showing signals in pericentromeric regions of all 39 chromosomes, unlike highly abundant repetitive DNA motifs found in survey genome sequences of C. ciliaris using graph-based clustering. Developed Cluster probes gave strong signals mostly in pericentromeric regions of about half of the chromosomes, and we suggested that they differentiate the two ancestral genomes in the allotetraploid C. ciliaris likely having different repeat sequence variants amplified before the genome came together in the tetraploid.
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Rôle et valeur pronostique des cellules T régulatrices chez les patients atteints de cancer pulmonaire, en fonction de la presence de structures lymphoïdes tertiaires
No full textTumor comprise complex niche of the immune and non-immune components. The complex interaction between the tumor cells with its environment turns into either eradication or the growth and metastasis of the tumors. We have previously demonstrated the role of TLS (tertiary lymphoid structures) in lung tumors, in protective anti-tumor responses. Despite of this, tumors do develop via exploiting the regulatory mechanisms, particularly includes, infiltration of the Tregs (regulatory T cells). The aim of thesis was to study the putative role of Tregs in regulating the immune responses in lung cancer. This study strongly demonstrates the presence of FoxP3+ Tregs in the TLS as well as non-TLS areas of the lung tumors. Tregs mainly exhibit central and effector memory phenotype expressing vast repertoire of the activation and immune checkpoint molecules. The gene expression and flow cytometry data showed that Tregs express the co-stimulatory and inhibitory markers which are known to be involved in the their activation and immune suppression. The high density of the Ti-Tregs either in TLS or in nonTLS areas is associated with the poor survival of the NSCLC patients. When combined with the density of TLS mature DC or B cells or CD8+ T cells, a group of patients with the low DC, B cells and CD8+ T cells but high Tregs densities, had the worst clinical outcome. This allowed, to identify the NSCLC patients with highest risk of death. Thus, it be concluded that the Tregs create the immunosuppressive environment in the lung tumors by acting in both TLS and nonTLS areas of the tumors and thus could be possible reason for the reduced survival of the lung cancer patients.Une tumeur est un environnement complexe comprenant à la fois des composants immunitaires et non immunitaires. Dans notre équipe, nous avons démontré précédemment le rôle des structures lymphoïdes tertiaires (TLS) dans les cancers du poumon, dans la génération de réponses anti-tumorales protectrices. Cependant, les tumeurs peuvent se développer en utilisant des mécanismes d’immunosuppression tels que l’infiltration des cellules T régulatrices (Tregs) dans le microenvironnement tumoral. Cette thèse a étudié le mécanisme présumé des Tregs dans la régulation des réponses immunitaires dans le cancer du poumon. Cette étude démontre la présence de Tregs FoxP3+ dans les TLS aussi bien que dans les autres régions tumorales. Les Tregs infiltrant la tumeur (Ti-Tregs) présentent un phénotype de lymphocytes T à mémoire centrale, et effecteur mémoire. Ces cellules expriment un vaste répertoire de molécules d’activation et de « chekpoints » immunologiques. L’analyse de l’expression des gènes et des résultats de cytométrie en flux a montré que les Tregs expriment des marqueurs de co-stimulation et de co-inhibition. Une forte densité de Ti-Tregs dans les TLS ou les autres régions tumorales, est associée à une faible survie des patients. Lorsqu’on combine ce résultat avec la densité de DC matures ou lymphocytes B associés aux TLS ou CD8+, un groupe de patients présentant de faible densités de ces cellules mais de fortes densités en Tregs a le pronostic le moins favorable avec le plus grand risque de décès. Les Tregs créent un environnement immunosuppresseur dans les cancers pulmonaires. Ce mécanisme pourrait être une explication de la réduction observée de la survie de ces patients
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