6 research outputs found
Impact of Acute Kidney Injury in Patients with Acute Decompensated Heart Failure: Cardiorenal Syndrome
No full textIn “Impact of Acute Kidney Injury in Patients with Acute Decompensated Heart Failure: Cardiorenal Syndrome” (Indonesian Journal of Cardiology, 44(2), 75-86. https://doi.org/10.30701/ijc.1561), there are an errors noted.
An error has been found in the PDF version of this article. The DOI printed in the PDF is incorrect. The correct DOI is https://doi.org/10.30701/ijc.1561. The error occurs only in the PDF; the DOI listed in the article metadata is already correct.
An error was also found in the author's name, Sagar Tandel. We have corrected the author name from “Sager Tandel” to “Sagar Tandel”.The publisher apologizes for any inconvenience caused by this error.DOI of original article: https://doi.org/10.30701/ijc.156
Structural characterization of nanocrystalline cadmium sulphide powder prepared by solvent evaporation technique
No full text
HPLC and HPTLC methods for simultaneous quantification of Metformin hydrochloride, Vildagliptin and Dapagliflozin propanediol with comparative evaluation by greenness and whiteness assessment tools
No full textThe combination of Vildagliptin, Dapagliflozin propanediol monohydrate and Metformin hydrochloride has been approved by Central Drug Standard Control Organization in March 2023 for conducting Phase III trial for treatment of diabetes mellitus. None of the chromatographic methods are reported for the proposed combination. In context to this, the proposed work aims to develop and validate two chromatographic methods, high HPLC and HPTLC for simultaneous estimation of the said combination followed by validation in accordance to ICH Q2(R2). For HPLC, linearity range were, 300–700, 30–70 and 3–7 µg/ml for Metformin hydrochloride, Vildagliptin and Dapagliflozin propanediol respectively. Good resolution was obtained with the final mobile phase, Acetonitrile: 10 mM potassium dihydrogen phosphate buffer pH 6.5 set with TEA (75:25 %v/v). The flow rate was 1 ml/min and detection wavelength was 214 nm. Rt of Metformin hydrochloride, Vildagliptin and Dapagliflozin propanediol was 2.262, 3.956 and 11.411 min respectively. For HPTLC the linearity range set was 1000–5000, 5000–9000 and 1000–5000 ng/band for Metformin hydrochloride, Vildagliptin and Dapagliflozin propanediol respectively. Separation of all drugs was observed using optimized mobile phase, Toluene: Ethyl acetate: 3% Ammonium acetate: Triethylamine(4: 4: 3: 0.1). Rf for Metformin hydrochloride, Vildagliptin and Dapagliflozin propanediol was 0.19, 0.48 and 0.61 respectively at 214 nm. % Relative Standard Deviation for validation parameters of both methods were found to be <2, which indicates that the methods were validated properly as per guideline. The proposed methods were specific, reliable, precise and can be applicable in routine analysis. Analytical Eco-Scale, Analytical GREEnness metric, and complex Green Analytical Procedure Index were the three methods used to assess the greenness. Furthermore, the quality (R), ecological effect (G), and economic feasibility (B) of the new technique were assessed by RGBfast tool for whiteness assessment and the applicability evaluated by the BAGI metric tool for performance verification
Stability indicating HPTLC method development and validation for simultaneous analysis of Levodropropizine and Chlorpheniramine Maleate in syrup formulation
No full textAbstract We report herein, an accurate, precise, specific and robust high-performance thin layer chromatographic technique along with forced degradation testing was established and validated for analysis of Levodropropizine and Chlorpheniramine Maleate in pharmaceutical formulation. Robustness study was conducted by using fractional factorial design. The 24–1 design examined at both high level (+1) and low level (-1). Four factors were selected in the design matrix which includes chamber saturation time, solvent front, wavelength, and methanol volume in mobile phase. Base, acid, oxidation, dry heat, and photodegradation tests were performed on both medications. The developed technique employed silica gel (60 F254) as a stationary component and Triethylamine: Toluene: Methanol (0.5:3:16 v/v/v) as the mobile phase mixture. A densitometric investigation conducted at 270 nm showed a strong, symmetrical peak for Chlorpheniramine maleate and Levodropropizine, with Rf values of 0.59 and 0.39, respectively. The ICH Q2(R2) recommendation was implemented in the validation of the procedure. For Levodropropizine and Chlorpheniramine maleate, the calibration curve regression coefficients were determined to be 0.9959 and 0.9943 in the range of concentrations of 1500–7500 and 100–500 ng/band, respectively. The technique had a correctness of 97.07% for Levodropropizine and 96.12% for Chlorpheniramine Maleate, respectively. In Robustness study methanol volume in mobile phase, chamber saturation time and wavelength have minor effect on response of Rf value. Levodropropizine and Chlorpheniramine Maleate are susceptible to chemical oxidation, photolytic study, base hydrolysis, and dry heat degradation while both the drugs have less degradation in wet heat and acid hydrolysis
High spin spectroscopy and shape coexistence in As-73
No full textHigh spin states in As-73 have been investigated through the fusion-evaporation reaction Ni-64(C-12, p2n)As-73 with an incident beam energy of 55 MeV. The level scheme has been extended up to J(pi) = (37/2(-)) and excitation energy similar to 8.7 MeV with the addition of 30 new gamma-ray transitions. The microscopic origins of the observed positive- and negative-parity band structures are discussed in the context of the particle rotor model. Nucleon alignments and shape evolution with increasing angular momentum are discussed in the framework of the cranked shell model and relativistic mean-field calculations. The results offer insight into the nature of the observed band structures and indicate prolate-oblate shape coexistence between positive- and negative-parity bands at low spin.IUAC, New Delhi [42328]; Council of Scientific and Industrial Research (CSIR), India [09/002(0494)/2011-EMR-1]SCI(E)[email protected]
