316 research outputs found
Synchronous existence of granular cell tumor and small cell carcinoma of lung: An unusual entity
No full textGranular cell tumor (GCT) is a rare benign mesenchymal tumor that uncommonly occurs in the lung and tracheobronchial tree. Small cell carcinoma of lung is a centrally located malignant neoplasm that commonly occurs in elderly smokers. Concomitant existence of both the neoplasm in lung is extremely rare with only one reported case in the literature. Few rare combinations of GCT with other primary bronchogenic carcinomas have also been reported. Clinical symptoms depend upon the site and size of the tumor. Definitive diagnosis is by histopathological and proper immunohistochemical analysis. Identification of this entity is important as treatment requires individual therapy protocols that depend on the presence of metastasis, location of the tumors, and type of bronchogenic carcinoma
Primary pulmonary leiomyosarcoma of lung: An unusual entity with brief review
No full textPrimary pulmonary leiomyosarcomas are rare and diagnostically challenging group of neoplasms approximately constituting 0.2-0.5% of all primary lung malignancies. They originate from the smooth muscle cells of the bronchial wall, blood vessels or from the pulmonary interstitium. Here we present a case of 45 year old male with history of chronic cough, breathlessness and chest pain for few months. Clinical and radiological workup showed a left upper lobe lung mass. Endobronchial ultrasound guided (EUS) needle biopsy of the mass on histopathology confirmed leiomyosarcoma. Further through evaluation ruled out the possibility of metastasis. A final diagnosis of primary leiomyosarcoma of lung was made and patient was planned for surgical management
The development of supergravity grand unification: Circa 1982 1985
No full textThe development in the early eighties of supergravity grand unified models with gravity-mediated breaking of supersymmetry has led to a remarkable progress in the study of supersymmetry at colliders, in dark matter and in a variety of other experimental searches in the intervening years since that time. 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Immunohistochemical characterization of glandular elements in glandular cardiac myxoma: Study of six cases
No full textBack ground: Glandular cardiac myxoma has varying clinical presentation with uncertain histogenesis and debatable immunohistochemical profile. Glandular epithelial differentiations are rare phenomenon known to be present as an intrinsic component of the tumor. The origin of the glands has been attributed to epithelial differentiation of a totipotent cardiomyogenic precursor cells or the entrapped foregut rests in the tumor. Materials and Methods: Retrospective study includes six cases of glandular cardiac myxoma collected over a perior of 4 years. Sections were examined to define the histogenesis, histological and immunohistochemical profile of the glandular elements. Results: Incidence of glandular cardiac myxoma was 6.6% with a male to female ratio of 1:2.Mean age was 49.9 years. Left atrium was the commonest site. Five were sporadic and one was familial. Chest pain and dyspnea were the commonest clinical symptoms. Histologically all myxoma showed well formed glandular structures with typical myxomatous area. No atypia, mitosis or necrosis was identified in the glandular elements. Markers in six cases of glandular cardiac myxoma were immunopositive for CK7, CK 19, EMA, CEA, focally for E-cadherin while immunonegative for CK20, Chromogranin, Synaptophysin, calretenin, vimentin, B-catenin, TTF-1 and GCDFP-15 favoring enteric differentiation. Conclusion: Glandular cardiac myxoma is a rare entity which shows characteristics similar to those of classical cardiac myxoma with benign glandular elements showing enteric differentiation. Complete surgical excision is the treatment of choice with good prognosis. It is important to recognize this entity to avoid an erroneous diagnosis of metastatic adenocarcinoma
Familial biatrial cardiac myxoma with glandular elements: A Rare entity with review of literature
No full textCardiac myxomas are benign neoplasm of the heart with an incidence of 0.3%. Glandular cardiac myxomas are very rare and accounts for less than 3% of all cardiac myxomas. Here, we report a case of familial glandular cardiac myxoma in a 35 year old male who complained of exertional dyspneoa and weakness of right side of body on clinical presentation. Associated features of Carney's complex were not present. Family history revealed presence of cardiac myxoma in younger brother and sister. Transthoracic echocardiography detected biatrial myxoma. Excision of both lesions was done under cardiopulmonary bypass. Histopathology confirmed myxoma with glandular elements. Postoperative course was uneventful
Fluoride Anticoagulant Vials are Ideal for HbA1c Estimation in India
No full textIn developing country like India fasting (FBS) and post prandial blood sugar (PPBS) has always been used for diagnosing diabetes. HbA1c is seldom used for diagnosis. Almost all HbA1c test accompanies blood sugar tests, and only in 4.56% HbA1c is done alone. In this case two samples need to be collected one in Na‑fluoride/Na2 EDTA vials for blood sugar estimation and another in EDTA vial for HbA1c. We suggest through our study that the same Na‑fluoride/Na2 EDTA vials can be used for both the tests, without any change in test quality and results. This will reduce patients inconveniences and will also reduce the cost of HbA1c tests to a certain extent. [Med-Science 2015; 4(4.000): 2975-7
1. Speeches Delivered On The Occasion Of The Fifth All Nepal Medical Conferences
No full textA Challenges by Dr. Trailokya Nath Uprety, Vice Chancellor, Tribhuvan University.
A Few Odds And Ends In Nepal Medical World by Dr. Lakshmi Narayan Prasad, Out going-PRESIDENT, NMA.
Problems Facing The Medical Profession by Dr. Shanker Bahadur, President-Elect, NMA.
Speech Proposing A Toast For The Health Of Their Majesties by Dr.Shanker Bahadur, President, NMA
Comparison of NLR,LMR,PLR, RDW, and Platelet count in hematological malignancies at baseline and at intervals of 2 months in patients undergoing chemotherapy
No full textBlood cancer has become quite common in all age groups, worldwide. The cancer ranges from acute life
threatening leukemias to indolent chronic leukemias, Lymphoma spillovers causing morbidity and mortality to
slow-growing indolent lymphomas. Since blood is present everywhere in the body hence the spread of
hematological malignancies is massive. Chemotherapy is expensive and a must to treat blood cancers. However,
the ancillary workups like flowcytometry etc in prognosticating and diagnosing blood cancers become quite
cumbersome and heavy on the pocket for an average Indian. Therefore, the authors planned the study aimed at
analyzing-
-Trend in NLR,LMR, PLR RDW, Platelet count at baseline
-Trend in NLR,LMR, PLR RDW, Platelet count 2 months post-chemotherapy
-Comparison between 2 parameters for any significant change
The study was carried out on 11 cases as a prospective case-based study of 11 cases where pre and post-values of
chemotherapy cases of newly diagnosed blood cancer cases were available with the author. The baseline CBC and
post-induction 1 st CBC were used to record the variables under study and latest SPSS software was used to come
to a conclusion through the results.
The findings stated that there was a decline in NLR, PLR and platelet count at follow-up as compared to baseline
and an increase in LMR and RDW at follow-up as compared to baseline, however, the difference was significant
statistically only for PLR (p=0.028) and near significant (p=0.059) for platelet count.
Hence in view of significant findings seen only in 11 cases a larger cohort may be used to correlate these findings
with follow up of such cases
Vascular Cyst of Adrenal: A Report of Two Cases
No full textVascular cysts of the adrenal gland are rare heterogeneous group of lesions with an autopsy incidence of 0.06%. They have female preponderance with most common presentation being pain abdomen. Cysts of the adrenal glands are classified as (a) parasitic cysts (b) epithelial cyst (c) pseudocyst and (d) endothelial cysts. Out of these endothelial cysts constitute about 84% of the cases. As the clinical features and radiological findings of these lesions are nonspecific, a proper histological examination along with immunohistochemistry are necessary for a definitive diagnosis. Here, we report two cases of vascular endothelial cyst of the adrenal gland to emphasize the histomorphological and immunohistochemical features of these lesions
Recommended from our members
Intellectual property objectives in international investment agreements /
No full textThis timely book reconciles the competing objectives of intellectual property and international investment agreements. Throughout, Pratyush Nath Upreti examines the issues arising from recent intellectual property disputes in investment arbitration from the perspectives of national and international legal orders, providing a normative analysis to resolve the tension brought by intellectual property and investor-state dispute settlement interactions. The analysis that the book offers is not confined to the intellectual property regime; it takes a pragmatic approach in terms of substantial analysis by also exploring the international trade regime, investment law and arbitration to address the key challenges to intellectual property and investor-state dispute settlement interaction. The author also considers the emerging and potential transformation of international intellectual property law, putting more emphasis on the need to shelter its intrinsic value. This thought-provoking book will be a key point of reference for law scholars, practitioners, and students in both developing and developed countries who are interested in intellectual property, investment law, and arbitration. It is also an essential read for policy makers, government officers, and lawyers involved with trade and Investment agreement negotiations
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