1,338 research outputs found
C. C. Mehta
No full textOn the life and works of Chandravadan Chimanlal Mehta, b. 1901, Gujarati author
Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells
No full textCopyright @ 2011 Mehta et al.; licensee BioMed Central Ltd. This article has been made available through the Brunel Open Access Publishing Fund.
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.BACKGROUND: Hutchinson-Gilford progeria syndrome (HGPS) is a premature ageing syndrome that affects children leading to premature death, usually from heart infarction or strokes, making this syndrome similar to normative ageing. HGPS is commonly caused by a mutation in the A-type lamin gene, LMNA (G608G). This leads to the expression of an aberrant truncated lamin A protein, progerin. Progerin cannot be processed as wild-type pre-lamin A and remains farnesylated, leading to its aberrant behavior during interphase and mitosis. Farnesyltransferase inhibitors prevent the accumulation of farnesylated progerin, producing a less toxic protein. RESULTS: We have found that in proliferating fibroblasts derived from HGPS patients the nuclear location of interphase chromosomes differs from control proliferating cells and mimics that of control quiescent fibroblasts, with smaller chromosomes toward the nuclear interior and larger chromosomes toward the nuclear periphery. For this study we have treated HGPS fibroblasts with farnesyltransferase inhibitors and analyzed the nuclear location of individual chromosome territories. We have found that after exposure to farnesyltransferase inhibitors mis-localized chromosome territories were restored to a nuclear position akin to chromosomes in proliferating control cells. Furthermore, not only has this treatment afforded chromosomes to be repositioned but has also restored the machinery that controls their rapid movement upon serum removal. This machinery contains nuclear myosin 1β, whose distribution is also restored after farnesyltransferase inhibitor treatment of HGPS cells. CONCLUSIONS: This study not only progresses the understanding of genome behavior in HGPS cells but demonstrates that interphase chromosome movement requires processed lamin A.This work was funded by an ORSAS award and the Brunel Progeria Research Fund
The Folio: F. C. C. Magazine
No full textEditorial. pp. 1-2; Elegy Written in the College Hall. pp. 2-3; Higginbottom, Sam-Speech-Convocation Address. pp. 3-5; Higginbottom, Sam-Speech-Founder's Day Address. pp. 5-8; Juneja, H. L.-Speech-Valedictory Address. pp. 8-10; Krishan Dev Madan-News and Notes. pp. 10-11; Parikshat Dev-Societies. pp. 12-14; Hostel News. pp. 15-16; Creighton, Winsome-The Co-Eds' Corner. pp. 16; Painter, P. I.-Correspondence. 17-20; Story-The Sweet Sixteen. pp. 20-22; Hardev S. Sandhu-Article-Life. pp. 22-23; Omi Mehta-Article-Photography as an Art. pp. 24-25; Sud, H. L.-Story-Till We Meet Again. pp. 26-27; She. pp. 27; Baldev Raj-Story-The Traveller. pp. 28-29; Hamid, A.-Story-His Swan Song. pp. 29-30; [Hindi]. 8 p.; Punjabi Kiyari [Punjabi]. 8 p.; The Folio [Urdu]. 16 p.The Folio Editorial Board, 1940-41. before page
Mobilities in Religious Knowledge: Phiroz Mehta and the Logics of Transreligiosity in 1970s–80s South London
No full textThis paper examines transreligiosity in the context of the transmission of South Asian concepts of spirituality to the UK in the 20th century. Between the 1920s and 1990s, Indian teacher and author Phiroz Mehta (1902–1994) crossed borders in a colonial and postcolonial shuttling between India and the UK but also transgressed conceptual and practice borders of religion, teaching Indian religious concepts to post-Christian spiritual seekers in 1970s–80s South London. Mehta cultivated an elasticity between many religious and philosophical traditions, recognising the post-institutional fatigue of subjects who sought alternative forms of ‘belonging without believing’. Privileging the domestic space for teaching, as well as transitory ‘camp’ gatherings in the UK and Germany, Mehta often operated in the social margins, combining teachings from Hinduism, Buddhism, and Christianity with Zoroastrianism, Judaism (specifically Kabbalah), and Daoism. He offered his tutees the freedom to practice religion in whatever way they chose by drawing on a broad range of traditions concurrently to create a transreligiosity. This paper examines Panagiotopoulos and Roussou’s ‘transgressional webs of practising individualised forms of alternative spirituality’ in relation to Mehta’s followers in the 1970s-1980s and asks how transreligiosity relates to other theoretical analyses, such as religious exoticism, bricolage, religious appropriation, cultural re-articulation or assemblage. This paper focuses on qualitative interviews with original members of the Mehta community conducted between 2021 and 2022.</p
Design and development of a mechatronic training simulator for adult ECMO
No full textWidespread adoption of Extracorporeal Membrane Oxygenation (ECMO) in adults has been limited by unfamiliarity with the procedure, including cannulation and safe handling of the ECMO equipment. We present the design and development of a mechatronic training simulator for ECMO that can help medical professionals acquire the needed skills, gain familiarity, and reduce errors by practicing before performing the procedure on real patients. The trainer is designed as an ultrasound-compatible, wholesome simulator with realistic components such as synthetic blood vessels, cannulation pads, and a color-changing blood simulant to simulate oxygenation and deoxygenation. The simulator is integrated with a mathematical model of human physiology to simulate real-time patient vitals and training scenarios, and to control the trainer hardware. We present results related to successful cannulation under ultrasound scanning and a simple patient scenario of hypovolemia.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2021-05-01The student, Iti Mehta, accepted the attached license on 2019-04-24 at 10:58.The student, Iti Mehta, submitted this Thesis for approval on 2019-04-24 at 11:11.This Thesis was approved for publication on 2019-04-24 at 12:45.DSpace SAF Submission Ingestion Package generated from Vireo submission #13873 on 2019-08-22 at 15:08:02Made available in DSpace on 2019-08-23T20:36:09Z (GMT). No. of bitstreams: 2
MEHTA-THESIS-2019.pdf: 84393765 bytes, checksum: 74f0edf247057995595372eb8076e513 (MD5)
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Previous issue date: 2019-04-24Embargo set by: Seth Robbins for item 112203
Lift date: 2021-08-23T20:36:18Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 112203 on 2021-08-24T09:15:24Z
Optimal Bioeconomic Management Strategies for Prevention and Control of Invasive Alien Species
No full textPaper removed by author. Please see the current version, available online January 8, 2007: Mehta, S.V. et al. Optimal detection and control strategies for invasive species management. Ecological Economics (2007), doi:10.1016/j.ecolecon.2006.10.024Environmental Economics and Policy,
Design and implementation of a phase locked loop for high-speed serial links
No full textThe student, Rushabh Mehta, accepted the attached license on 2016-04-25 at 13:40.The student, Rushabh Mehta, submitted this Thesis for approval on 2016-04-25 at 13:46.This Thesis was approved for publication on 2016-04-27 at 14:52.DSpace SAF Submission Ingestion Package generated from Vireo submission #9475 on 2016-07-07 at 13:50:45Made available in DSpace on 2016-07-07T20:27:59Z (GMT). No. of bitstreams: 2
MEHTA-THESIS-2016.pdf: 13984347 bytes, checksum: 4ecb06c5c270bc1beffb061eeae85eef (MD5)
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Previous issue date: 2016-04-27Recent advances in the semiconductor industry and process technology scaling have increased the demand for fast, robust computing. The thirst for high-processing, low power ICs is ever increasing. This has pushed the demand for high data rates in wireless and wireline communication systems in the multi-Gbps range. With higher data rates, the I/O links need to scale proportionally. However, the I/O channel bandwidth has not scaled appropriately making it the biggest bottleneck in high-speed links. Parallel links have not been able to match this increasing system performance due to issues such as crosstalk, timing skew and packaging costs. Thus there is a need for high-speed serial links. For high-speed transmission of data, there arises a need for high-speed on chip clocking circuits making the use of Phase-Locked Loops (PLLs) imperative.
This thesis includes an overview of high-speed links along with the need for PLLs. An in-depth understanding of PLL theory, loop dynamics and behavioral and transistor level simulation follows. Performance metrics such as phase noise, random jitter and deterministic jitter are discussed. Finally, this thesis concludes with an insight into All Digital Phase-Locked Loops (ADPLLs).Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-05-01Embargo set by: Seth Robbins for item 93174
Lift date: 2018-07-07T20:28:14Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 93174
Lift date: 2018-07-07T20:35:34Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 93174 on 2018-07-08T09:15:20Z
The emergence of <i>Pax7</i>-expressing muscle stem cells during vertebrate head muscle development
No full textPax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury. Currently, the in vitro manipulation and culture of these cells is still in its infancy, yet muscle stem cells may be the most promising route towards the therapy of muscle diseases such as muscular dystrophies.It is often overlooked that muscular dystrophies affect head and body skeletal muscle differently. Moreover, these muscles develop differently. Specifically, head muscle and its stem cells develop from the non-somitic head mesoderm which also has cardiac competence. To which extent head muscle stem cells retain properties of the early head mesoderm and might even be able to switch between a skeletal muscle and cardiac fate is not known. This is due to the fact that the timing and mechanisms underlying head muscle stem cell development are still obscure. Consequently, it is not clear at which time point one should compare the properties of head mesodermal cells and head muscle stem cells.To shed light on this, we traced the emergence of head muscle stem cells in the key vertebrate models for myogenesis, chicken, mouse, frog and zebrafish, using Pax7 as key marker. Our study reveals a common theme of head muscle stem cell development that is quite different from the trunk. Unlike trunk muscle stem cells, head muscle stem cells do not have a previous history of Pax7 expression, instead Pax7 expression emerges de-novo. The cells develop late, and well after the head mesoderm has committed to myogenesis. We propose that this unique mechanism of muscle stem cell development is a legacy of the evolutionary history of the chordate head mesoderm
Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts
No full textThis article has been made available through the Brunel Open Access Publishing Fund.Background: Radial chromosome positioning in interphase nuclei is nonrandom and
can alter according to developmental, differentiation, proliferation, or disease status.
However, it is not yet clear when and how chromosome repositioning is elicited.
Results: By investigating the positioning of all human chromosomes in primary
fibroblasts that have left the proliferative cell cycle, we have demonstrated that in
cells made quiescent by reversible growth arrest, chromosome positioning is altered
considerably. We found that with the removal of serum from the culture medium,
chromosome repositioning took less than 15 minutes, required energy and was
inhibited by drugs affecting the polymerization of myosin and actin. We also
observed that when cells became quiescent, the nuclear distribution of nuclear myosin
1ß was dramatically different from that in proliferating cells. If we suppressed the
expression of nuclear myosin 1ß by using RNA-interference procedures, the
movement of chromosomes after 15 minutes in low serum was inhibited. When high
serum was restored to the serum-starved cultures, chromosome repositioning was
evident only after 24 to 36 hours, and this coincided with a return to a proliferating
distribution of nuclear myosin 1ß.
Conclusions: These findings demonstrate that genome organization in interphase
nuclei is altered considerably when cells leave the proliferative cell cycle and that
repositioning of chromosomes relies on efficient functioning of an active nuclear
motor complex that contains nuclear myosin 1ß.Brunel Open Access Publishing Fun
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