609 research outputs found
Happy Birthday Kapil Dev: Leader in cricket, leader in life
Get PDFThe greatest lesson that young people can learn from Kapil Dev’s life is to pursue a calling in life for the sheer joy that comes with a profound sense of dedication. All other outcomes and benefits are purely incidental and transitory
Kapil Dev Adhiakri's Quick Files
No full textThe Quick Files feature was discontinued and it’s files were migrated into this Project on March 11, 2022. The file URL’s will still resolve properly, and the Quick Files logs are available in the Project’s Recent Activity
Meeting the Radio Frequency Identification mandate
No full textThesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2004.Includes bibliographical references.Various retailers like Wal-Mart, Target, and Albertsons have announced their mandates asking their top suppliers to become RFID enabled beginning 2005. Meeting the mandate has become a sort of cost of doing business with Wal-Mart for suppliers. The objective of this thesis is to look for ways of meeting the mandate and preventing it from just becoming a cost of doing business with Wal-Mart. The thesis explores the various options available to suppliers and identifies the cost and benefit associated with each option and develops an evaluation methodology for the various options.by Kapil Dev Singh.M.Eng.in Logistic
2018 KAPIL-GOVIND -BARAI J LUMIN PAPER.pdf
No full textEnergy transfer from Cerium to Dysprosium has been explored
Health insurance support on maternal health care: evidence from survey data in India
No full textBackground: maternal health care financing is key to the smooth functioning of health systems in a country. In India, maternal health care still persists as a major public health issue. Adequate health insurance could transform the utilization of maternal health care services. Therefore, we aim to examine the health insurance policies that cover maternal health and their performance in India. Methods: the unit-level data of social consumption on health by the National Sample Survey Organizations, conducted in India (2017-18), are used. Bivariate analysis, logistic regression and propensity scoring matching are applied. Results: About 14.1% women are covered by health insurance support at the national level. Uninsured women are less likely to receive full antenatal care (ANC) services and institutional delivery. Socio-economic characteristics play a significant role in utilizing maternal health care benefits through health insurance support.Conclusions: our study concludes that the health insurance coverage is the most significant contributor to the better utilization of full ANC and institutional delivery at the national level and hindrances in accessing them. There is a need for proactive and inclusive policy development by the Government of India to incentivize public financing through health insurance, which can shrink the challenges of public health burden and reduce the health risk.</p
Supplementary – Supplemental material for Nano-graphene oxide/polyurethane nanofibers: mechanically flexible and myogenic stimulating matrix for skeletal tissue engineering
No full textSupplemental material, Supplementary for Nano-graphene oxide/polyurethane nanofibers: mechanically flexible and myogenic stimulating matrix for skeletal tissue engineering by Seung Bin Jo, Uyanga Erdenebileg, Khandmaa Dashnyam, Guang-Zhen Jin, Jae-Ryung Cha, Ahmed El-Fiqi, Jonathan C. Knowles, Kapil Dev Patel, Hae-Hyoung Lee, Jung-Hwan Lee and Hae-Won Kim in Journal of Tissue Engineering</p
Data used for the paper " A Google Trends Data Analysis of the Indian Economy: Sighting the Right Animal" by Dr. Manoj Bhatt and Mr. Kapil Dev Manhas
No full textGoogle Trends Data
and
Actual Data
on Employment, Unemployment, Inflation, GDP and IIP.</p
Management of Technology Driven Strategies for the Educators of Young Students
Get PDFPCF5 Theme: Children & Youth // Learning strategies and educator’s roles change as per learning need of the environment and there is a noticeable difference between traditional classroom setting and digital environment. The application of new technologies was heralded as a revolution for open learning teaching. It generated new hopes among educators and learners. The computers and information and communication technologies were expected to create an exciting learning scenario to overcome some of the constraints of the conventional system, imposed by limitations of time, space, cost and skill. It was argued that appropriate learning softwares could be an alternative to stereotype and less satisfactory learning resources as these have the potential to opt greater learning opportunity. // PID 70
Fatty acids and their metabolism critically regulate podocyte survival
Get PDFDiabetic nephropathy (DN) is the most common cause of end-stage renal disease in industrialized countries, and most affected patients have type 2 diabetes. Podocyte injury and loss are considered critical in the development, and progression of DN. Several factors of the diabetic milieu are well known to impair function and survival of podocytes. However, the role of free fatty acids (FFAs), which are elevated in type 2 diabetes, and the role of their metabolism are just emerging in the pathogenesis of DN. FFAs were reported to regulate podocyte survival. Saturated FFAs, i.e. palmitic acid, were found to induce endoplasmic reticulum (ER) stress and podocyte death, whereas monounsaturated FFAs, i.e. palmitoleic acid or oleic acid, were protective.
The aims of the present study were to investigate whether FFA metabolism is regulated in glomeruli of type 2 diabetic patients with DN and whether regulation of FFA metabolism affects the susceptibility of podocytes towards palmitic acid. Particularly, I aimed to investigate whether regulation of fatty acid oxidation (FAO) modifies palmitic acid-induced podocyte death. As genome wide association studies suggest that acetyl CoA carboxylase (ACC) 2, an important enzyme in the regulation of FAO, is involved in the pathogenesis of DN, I performed detailed studies investigating the role of ACCs in podocytes. Furthermore, I explored the effect of palmitic acid on podocytes in combination with well-known proapoptotic stimuli of the diabetic milieu.
The present study uncovered that palmitic acid can aggravate the toxicity of other factors which are known to be important in the pathogenesis of DN and which are considered to cause podocyte loss. In particular the toxicity of high glucose concentrations and transforming growth factor (TGF)-β are substantially increased by palmitic acid, whereas the effect of palmitic acid on tumor necrosis factor (TNF)-α induced podocyte death is discret.
In the main part of this study FFA metabolism and its effect on palmitic acid induced podocyte death was investigated. The study finds that in glomeruli of type 2 diabetic patients mRNA expression levels of several key enzymes involved in fatty acid metabolism are altered. Of particular relevance for my detailed studies on FAO, a significant upregulation of all three isoforms of carnitine palmitoyltransferase (CPT)-1, the rate-limiting enzyme for FAO, and a downregulation of ACC-2, which catalyzes the formation of the CPT-1 inhibitor malonyl-CoA, are found which suggest a disposition for increased FAO. In vitro, stimulation of FAO by aminoimidazole-4-carboxamide-1β-D-ribofuranoside (Aicar) or by adiponectin, activators of the low-energy sensor AMP-activated protein kinase (AMPK), protect from palmitic acid induced podocyte death. Conversely, inhibition of CPT-1, a downstream target of AMPK, by etomoxir augments palmitic acid toxicity and impedes the protective Aicar effect. Etomoxir blocked the Aicar induced FAO measured with tritium labeled palmitic acid. Of note, only double knockdown of ACC1 and ACC2 has a protective effect on palmitic acid induced cell death, which indicates that both isoforms contribute to the regulation of FAO in podocytes. Furthermore, the effect of Aicar is associated with a reduction of ER-stress as indicated by a significant attenuation of the palmitic acid induced upregulation of immunoglobulin heavy chain binding protein (BiP), an ER chaperone, and of the proapoptotic transcription factor C/EBP homologous protein (CHOP).
In conclusion, palmitic acid increases the toxicity of other factors known to contribute to podocyte loss, which underlines the potentially important contribution of elevated saturated FFAs in the pathogenesis of DN. An important role of FFAs and of their metabolism in the pathogenesis of DN is further suggested by profound changes in gene expression levels of key enzymes of FFA metabolism in glomerular extracts of type 2 diabetic patients. The changed expression profile indicates a compensatory, protective response. Moreover, the results of this study uncover that stimulation of FAO by modulating the AMPK-ACC-CPT-1 pathway protects from palmitic acid induced podocyte death. The results of this study should encourage further investigations to evaluate the therapeutic potential of interfering with FFA metabolism specifically with stimulating FAO for the prevention and therapy of DN
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