2 research outputs found
PENGEMBANGAN BAHAN AJAR INTERAKSI SOSIAL BERBASIS INKUIRI UNTUK MENINGKATKAN KETERAMPILAN SOSIAL SISWA KELAS V SEKOLAH DASAR
No full textPenelitian ini dilatarbelakangi oleh rendahnya keterampilan sosial siswa di sekolah
dan dikarenakan belum adanya bahan ajar yang mengintegrasikan keterampilan
sosial dengan materi interaksi sosial. Penelitian ini bertujuan untuk
mengembangkan bahan ajar interaksi sosial berbasis inkuiri untuk meningkatkan
keterampilan sosial siswa kelas V Sekolah Dasar. Metode penelitian yang
digunakan dalam penelitian ini adalah metode Design and Development (D&D)
yang dikembangkan oleh Richey & Klein dengan model ADDIE, yaitu tahap
Analysis, Design, Development, Implementation, and Evaluation. Pengembangan
desain bahan ajar dilakukan peneliti disusun secara sistematis berdasarkan
komponen bahan ajar yaitu, halaman depan bahan ajar, identitas siswa, deskripsi
bahan ajar, petunjuk penggunaan, daftar isi, pemetaan kompetensi dasar, indikator
pencapaian kompetensi, isi/ materi bahan ajar sesuai dengan model inkuiri, latihan
soal, lembar kerja siswa, evaluasi, refleksi, kata penutup, daftar pustaka, dan
identitas penulis. Penilaian validasi yang dilakukan kepada ahli materi, ahli desain
dan ahli pembelajaran. Hasil penelitian ini menunjukan bahwa penilaian dari ketiga
ahli tersebut persentase rata-rata nilai 82,07%. Dari ahli materi menunjukan
kategori sangat baik dengan nilai 83 %, oleh ahli desain menunjukkan kategori baik
dengan rata-rata nilai 74,3%, dan oleh ahli pembelajaran menunjukan kategori
sangat baik dengan nilai 88.7%. Bahan ajar interaksi sosial dilakukan uji coba
kepada siswa kelas V Sekolah dasar melalui pre-test dan post-test. Hasil uji coba
bahan ajar ini menunjukan peningkatan hasil pre-test dan post-test dari rata-rata
61,1 menjadi 90,7. Selain itu, peneliti melakukan uji N-gain dari N-gain dari pre�test dan post-test yang sudah dikerjakan oleh siswa, hasil perhitungan rata-rata
menunjukan nilai 76,09% dengan kategori efektif. Dengan demikian, dapat
dikatakan bahwa pengembangan bahan ajar interaksi sosial berbasis inkuiri layak
digunakan dan dapat meningkatkan keterampilan sosial siswa kelas V SD.
This research was motivated by the low social skills of students in schools and
because there were no teaching materials that integrated social skills with social
interaction materials. This study aims to develop inquiry-based social interaction
teaching materials to improve the social skills of grade V elementary school
students. The research method used in this study is the Design and Development
(D&D) method developed by Richey & Klein with the ADDIE model, namely the
Analysis, Design, Development, Implementation, and Evaluation stage. The
development of teaching material design is carried out by researchers arranged
systematically based on the components of teaching materials, namely, the front
page of teaching materials, student identity, description of teaching materials,
instructions for use, table of contents, basic competency mapping, indicators of
competency achievement, content / teaching material in accordance with the
inquiry model, practice questions, student worksheets, evaluation, reflection,
afterword, bibliography, and author identity. Validation assessments are carried
out to material experts, design experts and learning experts. The results of this
study showed that the assessment of the three experts had an average score of
88.07%. From material experts showed a very good category with a score of 84%,
by design experts showed a good category with an average score of 74.3%, and by
learning experts showed a very good category with a score of 88.7%. Social
interaction teaching materials were tested for grade V elementary school students
through pre-test and post-test. The results of this teaching material trial showed an
increase in pre-test and post-test results from an average of 61.1 to 90.7. In
addition, researchers conducted an N-gain test of N-gain from pre-test and post�test that had been done by students, the average calculation results showed a value
of 76.09% with the effective category. Thus, it can be said that the development of
inquiry-based social interaction teaching materials is feasible and can improve the
social skills of grade V elementary school student
Prediction of Secondary Metabolite Compounds in Lotus (Nelumbo nucifera Gaertn.) Targeting Androgen-α Receptors for Breast Cancer Treatment Using Molecular Docking
No full textBreast cancer (BC) is a malignant tumor that grows in the breast tissue and can spread to other organs. BC is often found at an advanced stage and therefore has a poor prognosis. With 68,858 cases, BC is the most common type of cancer in Indonesia. The development of breast carcinoma is strongly influenced by steroid hormones and their receptors, such as estrogen, progesterone, and androgen. Androgen receptors (AR) are found more (70-90%) compared to estrogen receptors (60-80%) and progesterone receptors (50-70%). Therefore, research on natural compounds that inhibit cancer cell proliferation influenced by AR needs to be increased. The lotus plant (Nelumbo nucifera Gaertn.) has been used as a traditional herbal medicine and food in Asia. Bioactive compounds in lotus have therapeutic potential against BC. In the pharmacophore screening results, five hit compounds were found: isorhamnetin, luteolin, catechin, kaempferol, and apigenin. The compound with the best pharmacophore fit score value is isorhamnetin with a value of 41.31, while the compound with the best binding affinity to AR is kaempferol with a binding affinity of -9.44 and an inhibitor constant of 121.12 nM.Keywords: breast-cancer, androgen-α receptor, lotus, molecular docking
