2 research outputs found
A Review on Various Analytical Methodologies for Etoricoxib
No full textEtoricoxib belongs to the class of highly selective COX-2 inhibitor NSAIDs. It is mostly used for the treatment of pain, arthritic conditions including rheumatoid arthritis and osteoarthritis. The current study focuses primarily on analytical and bioanalytical method development methodologies, as well as numerous methods established for the estimation of etoricoxib, whether in pharmaceutical dose form or in bulk. Analytical procedures are critical for determining compositions, as they allow us to obtain both qualitative and quantitative results utilising advanced analytical tools. The analytical method for Etoricoxib may be chromatographic, electrochemical, spectral or hyphenated. These methods aid in the comprehension of critical process parameters as well as the minimization of their impact on precision and accuracy. Analytical method development is required to sustain high commercial product quality standards and to meet regulatory requirements. Following the reference, regulatory organisations in several nations have established standards and procedures for providing approval, authentication, and registration. Bioanalytical methods are designed to quantify the concentration of drug, metabolite, or typical biomarkers from various biological fluids including serum, urine, saliva and tissue extracts
Neuropharmacological Evaluation of Aqueous Extracts of Tecoma stans Linn in Mice Models
No full textMood disorders such as major depression and bipolar disorder continue to be leading contributors to global morbidity, often resulting in reduced productivity and increased healthcare burden. According to the World Health Organization (2001), only a small proportion of the estimated 450 million individuals affected by mental or behavioral disorders receive adequate treatment. These conditions accounted for 12.3% of the global disease burden, with projections suggesting a rise to 15% by 2020. This study aimed to evaluate the neuropharmacological effects of Tecoma stans flowers in mice, with a focus on validating their traditional medicinal use. The flowers were shade-dried, powdered, and sequentially extracted using solvents of increasing polarity. The aqueous extract was administered orally at doses of 200 mg/kg and 400 mg/kg. Behavioral assessments focused on antipsychotic and CNS depressant activity, and the data were analyzed using one-way ANOVA followed by Dunnett’s post hoc test. The results showed that the aqueous extract of Tecoma stans significantly reduced amphetamine-induced stereotypic behaviors and increased pentobarbitone-induced sleeping time in a dose-dependent manner. These findings suggest that the plant possesses notable antipsychotic and CNS depressant properties, supporting its traditional use in managing neuropsychiatric conditions
