216 research outputs found
The 4D-R Method of Imagining the Future, Part 2: Considerations on Design, Development, and Use
No full text To fill a methodological gap in vocational discipleship methods, the author developed the 4D-R method for vocational discipleship. The author then embedded the 4D-R method in a reflective journal and conducted a qualitative study to understand adult evangelical Christians' experience with the 4D-R method. This article presents findings related to the design, development, and use of the 4D-R method. </jats:p
Potential Use of G Protein-Coupled Receptor-Blocking Monoclonal Antibodies as Therapeutic Agents for Cancers
No full textThe 4D-R Method of Imagining the Future, Part 1: Implications for Vocational Discipleship
No full text Commonly prescribed vocational discipleship strategies have been devoid of teaching methods specifically designed for engaging the imagination. To fill this methodological gap, the author developed the 4D-R method for imagining the future and conducted a qualitative study to understand adult evangelical Christians' experience of the method. The findings indicate that the 4D-R method for imagining the future could be a useful strategy for vocational discipleship, particularly in the area of vocational discernment. The findings further suggest a relationship between common vocational discipleship strategies and the 4D-R method for imagining the future. </jats:p
G protein-coupled receptor GPR19 regulates E-cadherin expression and invasion of breast cancer cells
No full textClose head-to-head juxtaposition of genes favors their coordinate regulation in Drosophila melanogaster
No full textAbstractThis report identifies a large number of gene-pairs in Drosophila melanogaster that share a common upstream region. 877 gene-pairs (∼12% of the genome) are separated by less than 350 bp in a head-to-head orientation. This positional relationship is more highly favored in flies than in other organisms. These gene pairs have a higher correlation of expression than similarly spaced genes that have head-to-tail or tail-to-tail orientations. Thus, the positional arrangement of genes appears to play a significant role in coordinating relative expression patterns and may provide clues for identifying the functions of unknown genes
WELL-POSEDNESS AND SCATTERING FOR THE ZAKHAROV SYSTEM IN FOUR DIMENSIONS
No full textThe Cauchy problem for the Zakharov system in four dimensions is considered. Some new well-posedness results are obtained. For small initial data, global well-posedness and scattering results are proved, including the case of initial data in the energy space. None of these results are restricted to radially symmetric data.NNSF of China [11371037]; Beijing Higher Education Young Elite Teacher Project [YETP0002]; Fok Ying Tong education foundation [141003]; German Research Foundation [CRC 701]SCI(E)[email protected]; [email protected]; [email protected]; [email protected]
Validation of Emotional Experience Moderates the Relation Between Personality and Aggression
No full textThis study examined if experimentally manipulated invalidation or validation of an emotional experience moderates the relation between five-factor personality characteristics and aggressive behavior. Participants were 69 undergraduates who, after undergoing a sad mood induction, were randomized to receive either a validating or invalidating comment before completing a behavioral measure of aggression. As predicted, experimental condition moderated the relation between personality and aggression such that participants who were average or low in agreeableness and conscientiousness were more aggressive when invalidated than validated, whereas participants who were high in these traits were low in aggression regardless of experimental condition. A three-way interaction emerged such that the two-way interaction between conscientiousness and experimental condition was significant only among participants who were average or high in neuroticism. This study is the first to demonstrate experimentally that big-five personality characteristics commonly linked to trait aggression may only produce aggressive behaviors under certain conditions, namely, invalidationPublished in: JEP Volume 8 (2017), Issue 2, 126-139
Potential Therapeutic Applications for Inhibitors of Autotaxin, a Bioactive Lipid-Producing Lysophospholipase D, in Disorders Affecting the Nervous System
No full textStereotyped fetal brain disorganization is induced by hypoxia and requires lysophosphatidic acid receptor 1 (LPA <sub>1</sub> ) signaling
No full text
Fetal hypoxia is a common risk factor that has been associated with a range of CNS disorders including epilepsy, schizophrenia, and autism. Cellular and molecular mechanisms through which hypoxia may damage the developing brain are incompletely understood but are likely to involve disruption of the laminar organization of the cerebral cortex. Lysophosphatidic acid (LPA) is a bioactive lipid capable of cortical influences via one or more of six cognate G protein-coupled receptors, LPA
1–6
, several of which are enriched in fetal neural progenitor cells (NPCs). Here we report that fetal hypoxia induces cortical disruption via increased LPA
1
signaling involving stereotyped effects on NPCs:
N
-cadherin disruption, displacement of mitotic NPCs, and impaired neuronal migration, as assessed both ex vivo and in vivo. Importantly, genetic removal or pharmacological inhibition of LPA
1
prevented the occurrence of these hypoxia-induced phenomena. Hypoxia resulted in overactivation of LPA
1
through selective inhibition of G protein-coupled receptor kinase 2 expression and activation of downstream pathways including G
αi
and Ras-related C3 botulinum toxin substrate 1. These data identify stereotyped and selective hypoxia-induced cerebral cortical disruption requiring LPA
1
signaling, inhibition of which can reduce or prevent disease-associated sequelae, and may take us closer to therapeutic treatment of fetal hypoxia-induced CNS disorders and possibly other forms of hypoxic injury.
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