472 research outputs found
E.T.\u27 Author William Kotzwinkle will Speak at UD Writers\u27 Workshop
No full textNews release announces that William Kotzwinkle, author of E.T. The Extraterrestrial, 14 children\u27s books and several screenplays, will speak at the University of Dayton and will serve as keynote speaker for the Annual UD Writers\u27 Workshop
Szafa marzeń. Dziecięce kryjówki w E.T. Stevena Spielberga
No full textThe filmmakers made efforts to present reality from a child’s viewpoint. Among the strategies applied for this purpose, we find a detailed approach to grasping the atmosphere of children’s bedrooms. The wardrobe, intimate lighting, cozy nooks and child’s props allow the creation of a space of autonomy and the uncanny effect, which slips away from adults’ perception. The author uses works on the anthropology of place, the psychoanalysis of dreams, film studies analyses of E.T. and also the history of cinematic representation of children’s worlds in order to describe the specificity of domestic space in Spielberg’s movie. At the same time, the author proposes that E.T. can be interpreted as a movie about the relative independence of children’s worlds in relation to the overpowering and stiflingAmerican suburbs. If we follow the proposed interpretation, then the popular judgment of E.T. as a conservative and family narration from Reagan’s days would seem to be too one-sided.The filmmakers made efforts to present reality from a child’s viewpoint. Among the strategies applied for this purpose, we find a detailed approach to grasping the atmosphere of children’s bedrooms. The wardrobe, intimate lighting, cozy nooks and child’s props allow the creation of a space of autonomy and the uncanny effect, which slips away from adults’ perception. The author uses works on the anthropology of place, the psychoanalysis of dreams, film studies analyses of E.T. and also the history of cinematic representation of children’s worlds in order to describe the specificity of domestic space in Spielberg’s movie. At the same time, the author proposes that E.T. can be interpreted as a movie about the relative independence of children’s worlds in relation to the overpowering and stiflingAmerican suburbs. If we follow the proposed interpretation, then the popular judgment of E.T. as a conservative and family narration from Reagan’s days would seem to be too one-sided
Evolutionary constraints in conserved nongenic sequences of mammals.
No full textMammalian genomes contain many highly conserved nongenic sequences (CNGs) whose functional significance is poorly understood. Sets of CNGs have previously been identified by selecting the most conserved elements from a chromosome or genome, but in these highly selected samples, conservation may be unrelated to purifying selection. Furthermore, conservation of CNGs may be caused by mutation rate variation rather than selective constraints. To account for the effect of selective sampling, we have examined conservation of CNGs in taxa whose evolution is largely independent of the taxa from which the CNGs were initially identified, and we have controlled for mutation rate variation in the genome. We show that selective constraints in CNGs and their flanks are about one-half as strong in hominids as in murids, implying that hominids have accumulated many slightly deleterious mutations in functionally important nongenic regions. This is likely to be a consequence of the low effective population size of hominids leading to a reduced effectiveness of selection. We estimate that there are one and two times as many conserved nucleotides in CNGs as in known protein-coding genes of hominids and murids, respectively. Polymorphism frequencies in CNGs indicate that purifying selection operates in these sequences. During hominid evolution, we estimate that a total of about three deleterious mutations in CNGs and protein-coding genes have been selectively eliminated per diploid genome each generation, implying that deleterious mutations are eliminated from populations non-independently and that sex is necessary for long-term population persistence
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