5,555 research outputs found

    Raw data (RF) provided for : Sensing Ultrasound Localization Microscopy reveals glomeruli in rats and humans

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    <p><strong>Abstract :</strong> Estimation of glomerular function is a key element in the diagnosis of kidney disease. However, the study of glomeruli in the clinic remains indirect through urine and blood tests. Recent imaging technique called Ultrasound Localization Microscopy (ULM) originated from the ability to record continuous movements of individual microbubbles in the bloodstream. Although it improved the resolution of vascular imaging up to tenfold, the imaging of the smallest vessels had yet to be reported.</p> <p>We acquired ultrasound sequences from living humans and rats and then applied filtering dividing the data set into slow-moving and fast-moving microbubbles. We performed a double tracking to highlight and characterize this new population of microbubbles with singular behaviors: we called this technique “sensing ULM” (sULM). We used post-mortem micro-CT for side-by-side confirmation in rats.</p> <p>In this study, we report the observation of microbubbles flowing in capillaries bundles, i.e. the glomeruli, in the kidney in living humans and rats. We introduce a set of analysis tools dedicated to extracting quantitative information from individual microbubbles, like the remanence time or the normalized distance.</p> <p>As glomeruli play a key role in kidney function, their observation could yield a deeper understanding of kidney diseases and provide a diagnostic tool for patients. More generally, it will bring imaging capabilities closer to the functional units of organs, which is one of the keys to understanding most diseases, like cancers, diabetes, or kidney failures.   </p> <p><strong>Academic reference to be cited : </strong>Denis, Bodard, Hingot, Chavignon, Battaglia, Renault, Lager, Aissani, Hélénon, Correas, and Couture. <em>Sensing Ultrasound Localization Microscopy reveals glomeruli in rats and humans,</em> eBioMedicine, 2023.</p> <p><strong>Article</strong> : <a href="https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00143-3/fulltext">https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00143-3/fulltext</a></p> <p><strong>Related scripts and software application</strong> : <a href="https://github.com/EngineerJB/akebia">https://github.com/EngineerJB/akebia</a></p> <p><strong>Beamformed dataset</strong> : <a href="../record/6811910#.ZA9dV3bMLid">https://zenodo.org/record/6811910#.ZA9dV3bMLid</a></p> <p><strong>Corresponding authors : </strong></p> <ul> <li>Article : Louise Denis, <a href="mailto:[email protected]">[email protected]</a>, Sylvain Bodard, <a href="mailto:[email protected]">[email protected]</a></li> <li>Scripts, and codes : Louise Denis, <a href="mailto:[email protected]">[email protected]</a>, Jacques Battaglia, <a href="mailto:[email protected]">[email protected]</a></li> <li>Materials, collaborations, rights and others: Olivier Couture, <a href="mailto:[email protected]">[email protected]</a></li> </ul><p>Additional information on the data is available at : </p> <p><strong>Related scripts and software application</strong> : <a href="https://github.com/EngineerJB/akebia">https://github.com/EngineerJB/akebia</a></p> <p><strong>Beamformed dataset</strong> : <a href="../record/6811910#.ZA9dV3bMLid">https://zenodo.org/record/6811910#.ZA9dV3bMLid</a></p> <p><strong>Article</strong> : <a href="https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00143-3/fulltext">https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00143-3/fulltext</a></p> <p> </p&gt

    Letter from Rose Cecil O'Neill to Mary Louise Clifton

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    A handwritten letter from Rose Cecil O'Neill to Mary Louise Clifton Womer regarding folk art in the Ozarks

    Effects of exercise training on energy balance of ovariectomized rats

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    Pages R740–R745: the authors of “Effects of exercise training on energy balance of ovariectomized rats” are Denis Richard, Louise Rochon, and Yves Deshaies. </jats:p

    Effects of exercise training on energy balance of ovariectomized rats

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    Pages R740–R745: the authors of “Effects of exercise training on energy balance of ovariectomized rats” are Denis Richard, Louise Rochon, and Yves Deshaies. </jats:p

    Comment la patrologie peut éclairer l'archéologie [À propos de l'Arbre de Jessé et des statues-colonnes de Saint- Denis]

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    Thérel Marie-Louise. Comment la patrologie peut éclairer l'archéologie [À propos de l'Arbre de Jessé et des statues-colonnes de Saint- Denis]. In: Cahiers de civilisation médiévale, 6e année (n°22), Avril-juin 1963. pp. 145-158

    From the IBPP Research Associates. Brazil: Louise Madeira

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    The author -Louise Madeira - is a psychologist working in Brazil. In this article, the Brazilian Economic Crisis is discussed

    Payton, Amy Louise. "Looking Back" radio show on Paytons book on Georgina Stirling.

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    CBC freelance broadcaster Cathy Porter talking to author Amy Louise Payton about the life of Georgina Stirling, Soprano Premadonna from Twillingate. Payton talks about her interest in the singer and her book on Stirling; Hiram Silk interviews Amy Louise Payton on the program Looking Back about her book Nightingale of the North about Georgina Stirling. Payton talks about Stirling and the history of the Twillingate area

    Talking to Louise Bourgeois

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    A narrative text describing a fictive series of events. The narrator (first person) attempts to interview the celebrated artist Louise Bourgeois in her London studio, and events unfold, leading to his becoming her studio assistant. The text is interwoven with the narrative of an artist from an unspecified South or Central American country, living in London. There is another text including elements of the first narrative set in a different context, and a further text describing thought processes involved in making a particular painting. The texts serve to problematise the notion of authenticity, identity, originality and the role of the artist. The text is derived from several paintings by the author

    D18747, Duval à Mme Denis

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    Autograph letter signed from Marc Duval to Marie-Louise Denis, dated 11 January 1774.</p
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