36,476 research outputs found
Postmarketing studies on safety of Dengfeng® shenmai injection
No full textAbstractObjectiveTo systematically research the postmarketing safety of Dengfeng® shenmai injection, identify potential risk factors, and ensure its clinical safety.MethodsWe investigated a comprehensive series of studies on the production process, quality standards, pharmacology, postmarketing clinical studies, and safety evaluation of Shenmai injection, including literature analysis of adverse drug reaction (ADR) case analysis and systematic review. Data from the hospital information system (HIS) and spontaneous reporting system (SRS) were also analyzed.ResultsThe approximate dosage leading to death in dogs is 45.0-67.5 g raw drug/kg and the toxic reactions are restlessness, skin irritation, salivation, and vomiting. The results of chronic toxicity tests in mice and dogs, and the other tests such as 6-month toxicity, drug safety, genetic toxicity, and reproductive toxicity of rats and dogs, were positive or qualified. Patient ADR history and ADR family history were closely associated with itching based on the data analysis from SRS. There was no damage to renal function from Shenmai injection use at a dosage and a treatment course outside the recommended dosage and treatment course as specified based on data analysis from HIS. The most common ADR from Shenmai injection are difficulty breathing, facial flushing, nausea, vomiting, chest tightness, skin itching, rash, and back pain.ConclusionThis study includes complete information on Shenmai injection ADR incidence rate. We found that Shenmai injection is safe and this study can provide clinical, research, and production institutions with an objective, reliable, and scientific basis for use of Shenmai injection
Special issue: Process safety in times of a pandemic
No full textGreen Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Safety and Security Scienc
Distributed human computation framework for linked data co-reference resolution
No full textDistributed Human Computation (DHC) is a technique used to solve computational problems by incorporating the collaborative effort of a large number of humans. It is also a solution to AI-complete problems such as natural language processing. The Semantic Web with its root in AI is envisioned to be a decentralised world-wide information space for sharing machine-readable data with minimal integration costs. There are many research problems in the Semantic Web that are considered as AI-complete problems. An example is co-reference resolution, which involves determining whether different URIs refer to the same entity. This is considered to be a significant hurdle to overcome in the realisation of large-scale Semantic Web applications. In this paper, we propose a framework for building a DHC system on top of the Linked Data Cloud to solve various computational problems. To demonstrate the concept, we are focusing on handling the co-reference resolution in the Semantic Web when integrating distributed datasets. The traditional way to solve this problem is to design machine-learning algorithms. However, they are often computationally expensive, error-prone and do not scale. We designed a DHC system named iamResearcher, which solves the scientific publication author identity co-reference problem when integrating distributed bibliographic datasets. In our system, we aggregated 6 million bibliographic data from various publication repositories. Users can sign up to the system to audit and align their own publications, thus solving the co-reference problem in a distributed manner. The aggregated results are published to the Linked Data Cloud
Late Neoarchean magmatism and tectonic evolution recorded in the Dengfeng Complex in the southern segment of the Trans-North China Orogen
No full textThe Dengfeng Complex exposed in Songshan area in the southern segment of the Trans-North China Orogen (TNCO) mainly consists of Late Neoarchean tonalite-trondhjemite-granodiorite (TTG) gneiss, metadiorite and amphibolite. The Sanhuangzhai amphibolite records the earliest mafic magmatism (2658 +/- 5 Ma) in the region, which is enriched in LREE and LILE with negative Nb, Ta and Ti anomalies and positive initial epsilon(Nd)(t) and epsilon(Hf)(t) values, suggested to be the remnant of an arc-related juvenile mafic crust. The Shipaihe amphibolite at the end of Neoarchean (2492 7 Ma) is characterized by flat REE pattern, slightly negative Nb, Ta and Ti anomalies and positive initial epsilon(Nd)(t) and epsilon(Hf)(t) values, which is interpreted as large-degree partial melt of metasomatised mantle source in a back-arc basin. Zircon U-Pb dating shows two episodes of TTG magmatism (2.57-2.55 Ga and 2.55-2.50 Ga) within the Dengfeng Complex. All TTG gneisses have high SiO2 and Na2O, but low Mg-#, Cr, Ni, DIAN and Y with high [La/Yb] N and Sr/Y. The early TTG gneiss (2.57-2.55 Ga) in the eastern Songshan area has variable whole-rock Hf-Nd isotopes (epsilon(Hf)(t) = -2.14-4.64; epsilon(Nd)(t) = 0.11-3.35; respectively), and its protolith is interpreted as the result of partial melting of a thickened lower crust with residual garnet and amphibole in the source. But the later TTG gneiss (2.55-2.50 Ga) in the western Songshan area has depleted whole-rock Hf-Nd isotopes (epsilon(Hf)(t) = 5.59-6.08; epsilon(Nd)(t) = 2.42-3.86; respectively), suggesting an overall juvenile source, and its protolith is interpreted as the partial melt of flat-subducting oceanic crust. The Shipaihe metadiorite is characterized by high Mg-#, Cr, Ni, Sr, Ba, highly fractionated REE patterns and strong negative Nb, Ta and Ti anomalies, resembling to sanukitoid suite, which is interpreted as the partial melt of a mantle wedge metasomatised by subduction-derived fluids/melts. Integrated geochronology and geochemical data of the Dengfeng Complex in Songshan area reveal the Late Neoarchean crustal accretion process from subduction to arc-continental collision (accretionary orogeny) followed by post-collisional extension (back-arc basin), implying an active continental margin arc environment in the southern segment of the North China Craton
Intersystem soft handover for converged DVB-H and UMTS networks
No full textDigital video broadcasting for handhelds (DVB-H) is the standard for broadcasting Internet Protocol (IP) data services to mobile portable devices. To provide interactive services for DVB-H, the Universal Mobile Telecommunications System (UMTS) can be used as a terrestrial interaction channel for the unidirectional DVB-H network. The converged DVB-H and UMTS network can be used to address the congestion problems due to the limited multimedia channel accesses of the UMTS network. In the converged network, intersystem soft handover between DVB-H and UMTS is needed for an optimum radio resource allocation, which reduces network operation cost while providing the required quality of service. This paper deals with the intersystem soft handover between DVB-H and UMTS in such a converged network. The converged network structure is presented. A novel soft handover scheme is proposed and evaluated. After considering the network operation cost, the performance tradeoff between the network quality of service and the network operation cost for the intersystem soft handover in the converged network is modeled using a stochastic tree and analyzed using a numerical simulation. The results show that the proposed algorithm is feasible and has the potential to be used for implementation in the real environment
Beyond interfaces: A usability study of Chinese journal databases
No full textA presentation at the Council on East Asian Libraries (CEAL) annual meeting in Boston, MA on March 21, 2007
Rose Galaida and the Central China Relief Records, 1946: Discovery, Investigation, and Implications
No full textThe materials in the Central China Relief Records (CCRR) collection provide a window to the experiences of Rose Galaida in Hubei. The collection consists of about 100 documents totaling over 300 pages (excluding duplicate copies) and 5 photographs.Peer reviewedPublished in the Journal of East Asian Libraries and available from the journal at: https://scholarsarchive.byu.edu/jeal/vol2011/iss153/
Breaking New Ground in East Asia Library History
No full textReview of Peter X. Zhou. Collecting Asia: East Asian Libraries in North America (2010).Published in H-Net Reviews in the Humanities and Social Sciences and available at: http://www.h-net.org/reviews/showrev.php?id=32231March 201
Detection and Exclusion of Faulty GNSS Measurements: A Parameterized Quadratic Programming Approach and its Integrity
No full textThis research investigates the detection and exclusion of faulty global navigation satellite system (GNSS) measurements using a parameterized quadratic programming formulation (PQP) approach. Furthermore, the PQP approach is integrated with the integrity risk and continuity risk bounds of the Chi-squared advanced receiver autonomous integrity monitoring (ARAIM). The integration allows for performance evaluation of the PQP approach in terms of accuracy, integrity, continuity, and availability, which is necessary for the PQP approach to be applied to the vertical navigation in the performance-based navigation (PBN). In the case of detection, the PQP approach can also be integrated with the vertical protection level and the associated lower and upper bounds derived for the solution separation ARAIM. While there are other computationally efficient and less computationally efficient fault detection andexclusion methods to detect and exclude faulty GNSS measurements, the strength of the PQP approach can summarized from two different perspectives. Firstly, the PQPapproach belongs to the group of the computationally efficient methods, which makes the PQP approach more favorable when it comes to detect and exclude multiple simultaneous faulty GNSS measurements. Secondly, because of the integration of the PQP approach with the integrity risk and continuity risk bounds of the Chi-squaredARAIM, the PQP approach is among the first computationally efficient fault detection and exclusion methods to incorporate the concept of integrity, which lies inthe foundation of PBN. Despite the PQP approach not being a practical integrity monitoring method in its current form because of the combinatorial natural of the integrity risk bound calculation and the rather conservative integrity performance, further research can be pursued to improve the PQP approach. Any improvement on the integrity risk bound calculation for the Chi-squared ARAIM can readily beapplied to the integrity risk bound calculation for the PQP approach. Also, the connection between the PQP approach and the support vector machines, the application of the extreme value theory to obtain a conservative tail probability may shed light upon the parameter tuning of the PQP approach, which in turn will result in tight integrity risk bound
One step preparation of pure tau-MnAl phase with high magnetization using strip casting method
No full textFerromagnetic phase of Mn-Al exhibits great potential in the rare-earth free permanent magnetic materials due to its high magnetocrystalline anisotropy, high magnetization, high Curie temperature and low cost. In this work, the strip casting technique was applied to prepare MnAl magnetic phase. X-ray diffraction and energy dispersive X-ray analyses indicate that the as-prepared Mn54Al46 strip sample consists of pure tau-MnAl magnetic phase. It is found that the composition of Mn54Al46 is suitable to prepare tau-MnAl phase during the strip casting process. The Mn54Al46 strip sample synthesized through the strip casting exhibits a fairly high magnetization of 114 emu/g under a field of 5 T, while the coercivity of iHc = 2.8 kOe, magnetization of M-5T = 63.9 emu/g at room temperature can be obtained for Mn54Al46 powder sample. This preparation method can produce a large amount of tau-phase MnAl alloy and promote mass industrialized production. (C) 2017 Author(s)
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