61,768 research outputs found
Recording of interview with Marinus van den Berg
No full textMarinus van den Berg is a Catholic pastor in Rotterdam; he was a student of Nouwen's in Utrecht and Yale.1 audio cassette (ca. 1 hr., 30 mins.)Title based on contents of the item. ; Located in audio cassettes box 16. ; The interviews are not transcribed. ; Digitized February 7, 2011.For more information please contact Special Collections, the University of St. Michael's College.Item consists of an interview (SR2009 02 105 93) with Marinus van den Berg conducted by Peter Naus in Rotterdam, The Netherlands on May 3, 2007
Portrait of Louis Nowra, author, 1981, 3 [picture] /
No full textTitle devised by cataloguer from inscription.; Part of the collection: Portraits of Louis Nowra, author, 1981.; Inscriptions: "Louis Nowra 5/2/81, H de Berg"--In ink on verso of print.; Condition: Soiled, scratched.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4728377
Portrait of Louis Nowra, author, 1981, 2 [picture] /
No full textTitle devised by cataloguer from inscription.; Part of the collection: Portraits of Louis Nowra, author, 1981.; Inscriptions: "Louis Nowra 5/2/81, H de Berg"--In ink on verso of print.; Condition: Soiled, scratched.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4728375
Portrait of Louis Nowra, author, 1981, 1 [picture] /
No full textTitle devised by cataloguer from inscription.; Part of the collection: Portraits of Louis Nowra, author, 1981.; Inscriptions: "Louis Nowra 5/2/81, H de Berg"--In ink on verso of print.; Condition: Soiled, scratched.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4728368
Portrait of Louis Nowra, author, in front of a tree, 1981 [picture] /
No full textTitle devised by cataloguer from inscription.; Part of the collection: Portraits of Louis Nowra, author, 1981.; Inscriptions: "Louis Nowra 5/2/81, H de Berg"--In ink on verso of print.; Condition: Soiled, scratched.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4728421
Portrait of Louis Nowra, author, leaning on a railing, 1981 [picture] /
No full textTitle devised by cataloguer from inscription.; Part of the collection: Portraits of Louis Nowra, author, 1981.; Inscriptions: "Louis Nowra 5/2/81, H de Berg"--In ink on verso of print.; Condition: Soiled, scratched.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4728382
VAN DEN BERG, J.J. Inventory of documents
No full textCOVERAGE 1953-1974; 14 Files; 0,33 Metre.Private papers of J.J. van den Berg, National Party MPC, Primrose
VAN DEN BERG, M.J. Inventory of documents
No full textCOVERAGE 1930, 1964-1965; 1 File; 0,11 Metre.Private papers of M.J. van den Berg, Labour Party MP Krugersdorp [1934-1948]; National Party MP Krugersdorp [1948-1970]
Supplementary Data for "Canine adrenomedullary and pheochromocytoma organoids: a novel in vitro model"
No full textSupplementary Data for "Canine adrenomedullary and pheochromocytoma organoids: a novel in vitro model".
van den Berg MF, Timmermans-Sprang EPM, Viets FC, van den Berg L, Danawar F, van Wolferen ME, Kooistra HS, Grinwis GCM, de Jong WHA, van Faassen M, Galac S.
Abstract
Background
Given the lack of effective medical treatment for pheochromocytomas (PCCs), a reliable in vitro model is needed to explore new therapies. Organoids are three-dimensional self-renewing structures that exhibit key features of their tissue of origin, providing valuable platforms for disease modeling and drug screening.
Aim
This study aimed to establish and characterize organoid cultures of canine normal adrenal medullas and PCCs.
Methods
Normal adrenal medullas from healthy dogs and tumor tissue from client-owned dogs with PCC were used to develop organoids. Primary cell suspensions were cultured in a 3D matrix, and organoids were established under optimized conditions. Organoids were characterized using histology, immunohistochemistry, immunofluorescence, qPCR, and metanephrine analysis by LC-MS/MS.
Results
Five adrenomedullary organoid lines were successfully established, demonstrating sustained growth. Organoid cultures were also derived from nine PCCs, although expansion was limited after passages 1-2. Both adrenomedullary and PCC organoids expressed differentiation markers (chromogranin A, synaptophysin, phenylethanolamine N-methyltransferase) and stem/progenitor markers (nestin, SOX10). Organoids retained key functional traits, as indicated by metanephrine levels in culture supernatants, which initially mirrored primary tumor patterns. A decline in both differentiation marker expression and metanephrine levels was observed over time, possibly due to organoid dedifferentiation or selective loss of differentiated chromaffin cells.
Conclusions
This study demonstrates the establishment of the first adrenomedullary and PCC organoid lines. While further optimization is needed, these organoids offer valuable potential as an in vitro model to investigate PCC pathophysiology and explore novel treatment strategies for this therapeutically challenging tumor
Annette Van Den Bosch at the Women and Arts Festival, Sydney, 2 October 1982 [picture] /
No full textTitle from acquisitions documentation.; Part of the: Hazel de Berg collection of photographs.; Also available online http://nla.gov.au/nla.pic-vn5760614
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