6 research outputs found
A surgical delivery system for targeted cancer gene therapy : the potential therapeutic role of genetically modified microvascular free flaps in the management of primary tumours
No full textTHESIS 8880Gene therapy has generated interest for the treatment of soft tissue malignancies. It offers the theoretical promise of delivering cytotoxic, immunomodulatory, or anti- angiogenic genes to produce proteins targeting tumour cells. The initial excitement generated by gene therapy has been tempered by the disappointing results of clinical trials. Some of the major barriers preventing gene therapy from achieving clinical use include the inability to accurately target the viral vector, insufficient levels of transgene expression, transient expression of the desired gene, and systemic host toxicity. This aim of this study was to address some of these issues by using a novel technique to transduce microvascular free tissue ex vivo. This approach limits systemic toxicity while also allowing a more targeted method of gene therapy delivery and would be useful after oncologic surgery for soft tissue cancers because many of these patients require microvascular reconstructions to repair the ablative defect
Does the use of dialogue journals affect the writing fluency of low-literacy adult Somali students?
No full textMotivated by the search for an effective writing tool to use with low-level students, the author examined dialogue journaling with seven adult Somali students. Word counts, recasting, and confidence levels were studied within the context of classroom action research conducted in a suburban school. Key influences included students, teaching colleagues, and journaling experts like Peyton, Staton, and Jones. Through an analysis of the journals, questionnaires, and interviews, the author analyzed what improvements occurred when journaling. This study showed that word counts gradually increased as the weeks progressed, that written recasting was generally not noticed by the students, and that students\u27 confidence levels in their writing abilities increased as a result of using the dialogue journals. An unexpected result lay in word counts being influenced by which topics were selected word counts soared when relating to Somali traditions, while topics that seemed more academic produced journal entries with fewer words
Research compendium: A systematic literature review of research conducted on Sclerotinia sclerotiorum
No full textWe aimed at summarising Sclerotinia related research, with emphasis on the management practices and strategies, using abstracts, keywords and titles from relevant published research articles. The objectives of this review were to identify countries from which the most Sclerotinia related articles are published as well as the host crop associated with each country, to determine leading first authors on Sclerotinia research, the author keyword most frequently used, and ultimately to identify the management practices researched the most. This article will assist researchers by illustrating the gaps and opportunities within the Sclerotinia research community
