5,348 research outputs found
Pioglitazone attenuates the opioid withdrawal and vulnerability to relapse to heroin seeking in rodents
No full textRationale: Relapse to opioids is often driven by the avoidance of the aversive states of opioid withdrawal. We recently demonstrated that activation of peroxisome proliferator-activated receptor gamma (PPARγ) by pioglitazone reduces the motivation for heroin and attenuates its rewarding properties. However, the role of PPARγ in withdrawal and other forms of relapse to heroin is unknown. Objectives: To further address this issue, we investigated the role of PPARγ on the development and expression of morphine withdrawal in mice and the effect of pioglitazone on several forms of heroin relapse in rats. Methods: We induced physical dependence to morphine in mice by injecting morphine twice daily for 6 days. Withdrawal syndrome was precipitated on day 6 with an injection of naloxone. In addition, different groups of rats were trained to self-administer heroin and, after the extinction, the relapse was elicited by cues, priming, or stress. The effect of different doses of pioglitazone was tested on these different paradigms. Results: Data show that chronic and acute administration of pioglitazone attenuates morphine withdrawal symptoms, and these effects are mediated by activation of PPARγ receptors. Activation of PPARγ by pioglitazone also abolishes yohimbine-induced reinstatement of heroin seeking and reduces heroin-induced reinstatement, while it does not affect cue-induced relapse. Conclusions: These findings provide new insights on the role of PPARγ on opioid dependence and suggest that pioglitazone may be useful for the treatment of opioid withdrawal in opioid-addicted individuals
Analgesic tolerance to morphine is regulated by PPARγ
No full textOpioid drugs are potent analgesics. However, their chronic use leads to the rapid development of tolerance to their analgesic effects and subsequent increase of significant side effects, including drug dependence and addiction. Here, we investigated the role of PPARγ in the development of analgesic tolerance to morphine in mice
The Rhetoric of Landscape in Gregory of Nyssa’s Homilies on the Song of Songs
No full textThis is the author accepted manuscript. The final version is available from Brill via the ISBN in this recordAnalytical and Supporting Studies. Proceedings of the 13th International Colloquium on Gregory of Nyssa (Rome, 17-20 September 2014)Series:
Vigiliae Christianae, Supplements, Volume: 150In this paper I want to take you on a walk through a garden. It is, to be sure, an imaginary garden; nevertheless, it bears a significance which extends beyond itself. Some of this significance concerns words and texts: for as we shall see, the garden is, amongst other things, a ‘garden of rhetoric’. The garden in question appears in the Gregory of Nyssa’s Homilies on the Song of Songs.[...
An Evening with Richard Claxton “Dick” Gregory, Civil Rights Activist, Nutritionist, Comedian, and Author
No full textGregory, Richard Claxton “Dick” (Born, October 12, 1932, St. Louis, Mo.), African American comedian and civil rights activist whose social satire changed the way white Americans perceived African American comedians since he first performed in public. Gregory’s autobiography, Nigger, was published in 1963 prior to The assassination of President Kennedy, and became the number one best-selling book in America. Over the decades it has sold in excess of seven million copies. His choice for the title was explained in the forward, where Dick Gregory wrote a note to his mother. “Whenever you hear the word ‘Nigger’,” he said, “you’ll know their advertising my book.” In 1984 he founded Health Enterprises, Inc., a company that distributed weight loss products. In 1987 Gregory introduced the Slim-Safe Bahamian Diet, a powdered diet mix, which was immensely profitable. Economic losses caused in part by conflicts with his business partners led to his eviction from his home in 1992. Gregory remained active, however, and in 1996 returned to the stage in his critically acclaimed one-man show, Dick Gregory Live! The reviews of Gregory’s show compared him to the greatest stand-ups in the history of Broadway
“Judge Me Gently”: Reflections on the Religious Life of John Milton Gregory, 1822–1898
No full text John Milton Gregory is familiar to many Christian educators through his 19th-century publication, The Seven Laws of Teaching. For most readers of this important book, little is known about the author himself. This article explores the religious life and theological foundations of John Milton Gregory, who was both author of The Seven Laws of Teaching and founding president of the University of Illinois. Utilizing his spiritual diaries preserved in his daughter's biography of her father and archival sources from the University of Illinois, this essay offers a theological and spiritual understanding of this important historical figure. </jats:p
David Gregory
No full textPhotograph - David Gregory, member of the Book Sub-Committee, part of the Town of Athabasca 75th Anniversary Committee, Athabasca, Alberta. The Book Sub Committee produced the book "Athabasca Landing: An Illustrated History
Improved Balloon
No full textLetter to the editor by J. Gregory describing his improved gas balloon, with an accompanying labeled mechanical illustration.For more information about this item, visit https://archivesspace.mit.edu/repositories/2/digital_objects/71
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Homeric Echoes in Posidippus
No full textLabored in Papyrus Leaves: Perspectives on an Epigram Collection Attributed to Posidippus (P.Mil.Vogl. VIII 309) is a Center for Hellenic Studies publication, specifically Hellenic Studies Series 2. Since Gregory Nagy is both article author and Director of the Center for Hellenic Studies, no special permission needed for online submission.The ClassicsAuthor's Origina
Columbus\u27s Ghost: Tourism, Art and National Identity in the Bahamas
No full textIan Gregory Strachan (1969-), Bahamian writer, Chair of English Studies at College of the Bahamas, author of God\u27s Angry Babies (1997) and Paradise and Plantation (2002)
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