114 research outputs found
Virus and Host Factors Regulating the Release of Extracellular Vesicle-enclosed Picornaviruses
No full textTo exchange information cells participate in the continuous exchange of small, membranous particles termed “extracellular vesicles” (EVs). These EVs carry status updates and instructions to neighbors, and can be compared to the cellular equivalent of sending an email or posting messages on social media. Although cell-to-cell communication via EVs is typically beneficial, these messages have the potential to turn corrupted during the development of disease. In the last years, a growing number of viruses were found capable of hiding in the EVs shuttled between cells. Similar to an email carrying a computer virus, the packaging of viruses within EVs enables viruses to bypass our body’s defenses by adopting a seemingly harmless exterior, and provides an alternative method for virus spread. In this dissertation, it was investigated how EV production of cells changes in response to virus infection and which proteins produced by the virus and the host cell regulate this process. Our data uncovers a previously unknown level of heterogeneity among the virus-containing EVs that are released during infection. We show that the spread of viruses via EVs is enhanced by drastic changes in the number and type of EVs that a cell produces, along with the activation of new EV-cargo sorting pathways. Finally, we demonstrate that these changes in EV production are the result of the interplay between the activity of dedicated viral proteins and cellular stress responses. These results provide novel insight into the virus-host interactions that determine the amount and phenotype of virus-carrying EVs released during infection
Interculturalizing the Campus: A Case Study
No full textOver the past two decades Thompson Rivers University has achieved many successes in
internationalization. TRU World, the international department, has excelled in international student
recruitment and services, transnational education, and unique international contract training. Since
2006 additional attention has been put to internationalization at home with focus on curricular,
co-curricular, and extra-curricular learning outcomes.Not peer reviewe
Book Review: Global citizenship education in post-secondary institutions
No full textPeer reviewedBook Revie
Reframing Internationalization
No full textCanadian higher education has long been involved in international education, partnerships, and research and development projects; however, recent framing of international education as an industry generating revenues to prop up underfunded institutions is troubling. This approach is endorsed by provincial government strategies and bolstered by the federal government’s recent International Education Strategy, which promotes doubling the recruitment of international students by 2022 (Canada, 2014). While it is true that international students bring economic benefits to the institutions and communities that host them, we should also consider the challenges that this numbers game potentially presents for education. Many institutions now strive to internationalize; although this can encompass a broad range of activities, for many, the focus has been on increasing international student enrolment. This paper argues that there is a need to reframe internationalization in Canada in a way that would acknowledge the economic rationales, yet balance them with the social and academic outcomes necessary for all students to develop the knowledge, attitudes, and skills necessary for effective participation as professionals and citizens in increasingly multicultural and global contexts. For internationalization to fully reach its potential, a reframing of internationalization at home, informed by critical global citizenship education, may offer a way to realize the social and academic outcomes that would support an ethical, inclusive, and equitable approach moving forward.Peer reviewedarticleOriginally Published in Canadian Journal of Higher Educatio
Virus and Host Factors Regulating the Release of Extracellular Vesicle-enclosed Picornaviruses
No full textTo exchange information cells participate in the continuous exchange of small, membranous particles termed “extracellular vesicles” (EVs). These EVs carry status updates and instructions to neighbors, and can be compared to the cellular equivalent of sending an email or posting messages on social media. Although cell-to-cell communication via EVs is typically beneficial, these messages have the potential to turn corrupted during the development of disease. In the last years, a growing number of viruses were found capable of hiding in the EVs shuttled between cells. Similar to an email carrying a computer virus, the packaging of viruses within EVs enables viruses to bypass our body’s defenses by adopting a seemingly harmless exterior, and provides an alternative method for virus spread. In this dissertation, it was investigated how EV production of cells changes in response to virus infection and which proteins produced by the virus and the host cell regulate this process. Our data uncovers a previously unknown level of heterogeneity among the virus-containing EVs that are released during infection. We show that the spread of viruses via EVs is enhanced by drastic changes in the number and type of EVs that a cell produces, along with the activation of new EV-cargo sorting pathways. Finally, we demonstrate that these changes in EV production are the result of the interplay between the activity of dedicated viral proteins and cellular stress responses. These results provide novel insight into the virus-host interactions that determine the amount and phenotype of virus-carrying EVs released during infection
Internationalization and intercultural learning: A mixed methods study
No full textThis chapter presents the findings of a mixed-method study that sought to measure upper level students’ intercultural development and their perceptions of intercultural learning in academic settings. Quantitative data was provided by participants (n=178) completing the Intercultural Development Inventory (IDI) and was
analyzed to determine which demographic variables influenced IDI scores. Focus groups provided qualitative data to understand students’ experiences learning in
multicultural, academic environments. The results show significant overestimation of intercultural competence in the sample, which taken together with the student
voice, provide a snapshot of intercultural learning and development across the disciplines. The findings clearly indicate a need for intentional pedagogy and curricular
revision in order to prepare graduates as professionals and citizens in increasingly multicultural and globalized contexts.Peer reviewedBook Chapte
Using Freewriting to Make Sense of Literature
No full textPeer reviewedPublished on The U.S. Department of State websit
Book review: Global citizenship education in post-secondary institutions
No full textPeer reviewedBook Revie
Ethical considerations for internationalization: Perspectives from global citizenship education
No full textNot peer reviewe
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