23 research outputs found
Maternal and environmental determinants of breast-milk mercury concentrations
No full textYalcin SS, Yurdakok K, Yalcin S, Engur-Karasimav D, Coskun T. Maternal and environmental determinants of breast-milk mercury concentrations. Mirk J Pediatr 2010; 52: 1-9
New perpective for an old problem: extracellular vesicle based management of respiratory distress syndrome
No full textSurfactant Protein D as a Novel Therapy for Periventricular Leukomalacia: Is It the Missing Piece of the Puzzle?
No full textActivation of microglia with an inflammatory insult, which plays a central role in periventricular leukomalacia (PVL), results in premyelinating oligodendrocyte death via release of certain cytokines, reactive oxygen and nitrogen species. Toll-like receptor (TLR) 4 is necessary for lipopolysaccharide (LPS) induced oligodenrocyte injury in the CNS. Having an ability to bind TLR 2, 4, and LPS receptor CD14, surfactant protein D (spD) may be a promising agent to counteract the pathways associated with PVL. Supplementation of surfactant treatment with spD may be the key point in prevention of PVL by supression of inflammation and preventing damage to pre-OLs in a vulnerable premature brain operating through TLRs
Measles Vaccine Failure in 9-month-old Infants
No full textObjective: Lower seroconversion rates in live attenuated measles vaccines are detected in children aged 9 months or younger. We aimed to evaluate the effect of some infant characteristics (including growth status, yogurt consumption, infectious diseases, anemia, and serum zinc and selenium levels) on primary measles vaccine failure
NLRP3 inflammasome: a key player in neonatal brain injury
No full textAmong neonates, hypoxic-ischemic encephalopathy is the most significant cause of mortality and hypoxia-ischemia is among the leading causes of brain damage. The microglia are primary mediators of neuroinflammation. NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation is the first line of defense in the central nervous system. Numerous studies have shown that the NLRP3 inflammasome is activated and proin-flammatory cytokines are upregulated upon hypoxiaischemia–induced brain damage. However, aberrant activation of the NLRP3 inflammasome results in cell death and brain tissue damage. Given that neonates are particularly vulnerable to neuroinflammation, which may cause lifelong disabilities, it is important to target the pathways involved in its complex nature to improve their prognosis. The potential use of compounds or drugs that target inflammasome activation to relieve hypoxiainduced brain damage has become significant. This review describes the NLRP3 inflammasome in neonates to contribute to the development of therapeutic approaches
https://www.labanimscience-ataunipress.org/en/highlights-for-the-research-involving-the-lactation-period-in-laboratory-rats-1327
No full textLactation is an important period in newborn nutrition since nutritional factors in the early stagesof development have life-long impacts. Lactation provides various important long-lasting healthbenefits to the offspring. The lactation period, however, provides much more than just nutrients.The composition and quantity of nutrients in breast milk are not the only factors that can influence offsprings during breastfeeding. Maternal behaviors to nourish and protect her litters during lactation are also important in programing. The current study attempted to focus on specificcharacteristics of the breastfeeding period, such as changes in food consumption, mother’sweight, and the time dams spend lactating with or without pups. A deeper understanding of thiscritical period will allow for designing better pediatric models including maternal separation, artificial rearing, and studies covering maternal manipulations.Keywords: Lactation period, maternal care, milk, mother rats, newborn </p
Zinc supplementation and TNF-alpha levels in vaccinated cardiac patients
No full textObjective: To investigate whether zinc supplementation could affect serum tumor necrosis factor-alpha (TNF-alpha) levels in congenital and acquired cardiac patients attending for an influenza vaccine
In vitro effects of H2O2 on neural stem cell differentiation
No full textThe development of the CNS is a complex and well-regulated process, where stem cells differentiate into committed cells depending on the stimuli from the microenvironment. Alterations of oxygen levels were stated to be significant in terms of brain development and neurogenesis during embryonic development, as well as the adult neurogenesis. As a product of oxygen processing, hydrogen peroxide (H2O2) has been established as a key regulator, acting as a secondary messenger, of signal transduction and cellular biological functions. H2O2 is involved in survival, proliferation, and differentiation of neural stem cells into committed cells of the CNS. Effects of different concentrations of exogenous H2O2 on neuronal differentiation and the molecular pathways involved are yet to be clearly understood. Here, we investigated the concentration-dependent effects of H2O2 on differentiation of neural stem cells using CGR8 embryonic mouse stem cell line. We have demonstrated that treated doses of H2O2 suppress neural differentiation; additionally, our study suggests that relatively high doses of exogenous H2O2 suppress the differentiation process of neural stem cells through AKT and p38 pathways
PP-142. Acinetobacter baumannii outbreak associated with breast-milk pump in a neonatal intensive care unit
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